{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:15:23Z","timestamp":1740147323644,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypothyroidism is diagnosed on the basis of laboratory tests because of the lack of specificity of the typical clinical manifestations. There is conflicting evidence on screening for hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We report a case of an apparently healthy 19-year-old Kuwaiti woman referred to our clinic with an incidental finding of extremely high thyroid-stimulating hormone (TSH), tested at the patient\u2019s insistence as she had a strong family history of hypothyroidism. Despite no stated complaints, the patient presented typical symptoms and signs of hypothyroidism on evaluation. Thyroid function testing was repeated by using different assays, with similar results; ultrasound imaging of the thyroid showed a typical picture of thyroiditis. Treatment with levothyroxine alleviated symptoms and the patient later became biochemically euthyroid on treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is controversy regarding screening asymptomatic individuals for hypothyroidism; therefore, it is important to maintain a high index of suspicion when presented with mild signs and symptoms of hypothyroidism especially with certain ethnic groups, as they may be free of the classical symptoms of disease.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13256-021-02677-w","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:06:28Z","timestamp":1614729988000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe primary hypothyroidism in an apparently asymptomatic 19-year-old woman: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-572X","authenticated-orcid":false,"given":"Rania","family":"Dannan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulaiman","family":"Hajji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Aljenaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"issue":"5","key":"2677_CR1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nrendo.2018.18","volume":"14","author":"PN Taylor","year":"2018","unstructured":"Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14(5):301\u201316.","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"2677_CR2","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.amjmed.2016.06.013","volume":"129","author":"A Carle","year":"2016","unstructured":"Carle A, Pedersen IB, Knudsen N, et al. Hypothyroid symptoms fail to predict thyroid insufficiency in old people: a population-based case\u2013control study. Am J Med. 2016;129(10):1082\u201392. https:\/\/doi.org\/10.1016\/j.amjmed.2016.06.013.","journal-title":"Am J Med"},{"issue":"Suppl 1","key":"2677_CR3","doi-asserted-by":"publisher","first-page":"A17","DOI":"10.1186\/1756-6614-8-S1-A17","volume":"8","author":"K Lewandowski","year":"2015","unstructured":"Lewandowski K. Reference ranges for TSH and thyroid hormones. Thyroid Res. 2015;8(Suppl 1):A17.","journal-title":"Thyroid Res."},{"issue":"1","key":"2677_CR4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/2230-8229.97886","volume":"10","author":"KT El-Shafie","year":"2003","unstructured":"El-Shafie KT. Clinical presentation of hypothyroidism. J Fam Community Med. 2003;10(1):55\u20138.","journal-title":"J Fam Community Med"},{"issue":"2","key":"2677_CR5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.5144\/0256-4947.1995.143","volume":"15","author":"AI Al-Sultan","year":"1995","unstructured":"Al-Sultan AI, Larbi EB, Magbool G, Karima T, Bagshi M. Clinical presentation of spontaneous primary hypothyroidism in adults. Ann Saudi Med. 1995;15(2):143\u20137.","journal-title":"Ann Saudi Med"},{"issue":"18","key":"2677_CR6","doi-asserted-by":"publisher","first-page":"981","DOI":"10.5694\/j.1326-5377.1972.tb103675.x","volume":"2","author":"TH Oddie","year":"1972","unstructured":"Oddie TH, Boyd CM, Fisher DA, Hales IB. 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Ann Intern Med. 2015;162(9):641\u201350.","journal-title":"Ann Intern Med"},{"issue":"7056","key":"2677_CR9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1136\/bmj.313.7056.539","volume":"313","author":"MPJ Vanderpump","year":"1996","unstructured":"Vanderpump MPJ, Ahlquist JAO, Franklyn JA, Clayton RN. Consensus statement for good practice and audit measures in the management of hypothyroidism and hyperthyroidism. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"108"}}