{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:25:27Z","timestamp":1750998327925},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Thyroid papillary carcinoma is one of the most common endocrine tumors, and it accounts for 85% of thyroid tumors. Adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome is a rare disease. In this case report, we discuss a very rare case of coexistence of papillary thyroid carcinoma and Cushing's syndrome with an adrenal origin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>The patient was a 33-year-old Iranian\/Persian woman with a history of papillary thyroid carcinoma treated with iodine 131 three years ago. She presented with weight gain, amenorrhea, and mood disorders in the last six months. She was diagnosed with an ACTH-independent Cushing's syndrome due to benign adrenal adenoma and underwent laparoscopic adrenalectomy surgery. The symptoms of the syndrome were disappeared after the surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>ACTH-independent Cushing's syndrome due to adrenal tumor and papillary thyroid cancer occurs sporadically. The co-occurrence of two endocrine tumors with different origins is rare. It is recommended that the occurrence of other endocrine neoplasms be considered when an endocrine tumor is diagnosed.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02684-x","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:06:52Z","timestamp":1615421212000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The occurrence of Adrenocorticotropic hormone-independent Cushing's syndrome in a woman with the history of papillary thyroid carcinoma: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Mashallah","family":"Tabatabaizadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Hasibi Taheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Eydi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Shayestehpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"2684_CR1","volume-title":"Harrison\u2019s principles of internal medicine","author":"JL Jameson","year":"2018","unstructured":"Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J. Harrison\u2019s principles of internal medicine. 20th ed. New York: McGraw Hill Education; 2018.","edition":"20"},{"issue":"1","key":"2684_CR2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000368750","volume":"4","author":"H Mazeh","year":"2015","unstructured":"Mazeh H, Orlev A, Mizrahi I, Gross DJ, Freund HR. Concurrent medullary, papillary, and follicular thyroid carcinomas and simultaneous Cushing\u2019s syndrome. Eur Thyroid J. 2015;4(1):65\u20138.","journal-title":"Eur Thyroid J."},{"key":"2684_CR3","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/1752-1947-7-200","volume":"7","author":"M Karakose","year":"2013","unstructured":"Karakose M, Hasdemir O, Cakal E, Delibasi T. A rare coexistence of non-functional adrenocortical carcinoma and multicentric papillary thyroid microcarcinoma: a case report. J Med Case Rep. 2013;7:200.","journal-title":"J Med Case Rep."},{"issue":"4","key":"2684_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/01.ten.0000170845.50695.27","volume":"15","author":"S-C Tung","year":"2005","unstructured":"Tung S-C, Wang P-W, Huang T-L, Yang JW, Chen W-J. Carney complex with primary pigmented nodular adrenocortical disease and bilateral papillary thyroid carcinoma occurring 11 years apart: a case report. Endocrinologist. 2005;15(4):243\u20137.","journal-title":"Endocrinologist."},{"issue":"7","key":"2684_CR5","first-page":"77","volume":"65","author":"AR Esteghamati","year":"2007","unstructured":"Esteghamati AR, Eshtiaghi R, Yousefizadeh AA, Nakhjavani M. Diagnosis and management of 253 cases with Cushing\u2019s syndrome in Imam Khomeini Hospital. Tehran Univ Med J. 2007;65(7):77\u201382.","journal-title":"Tehran Univ Med J."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02684-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-021-02684-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02684-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:10:57Z","timestamp":1615421457000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02684-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2684"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02684-x","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,11]]},"assertion":[{"value":"12 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by Ethics Committee of Kashan University of Medical Sciences. The patient was assigned an informed written consent form.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"113"}}