{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T22:35:23Z","timestamp":1762036523439,"version":"build-2065373602"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ProLUNG Estor"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acute severe asthma is a life-threatening medical emergency. Characteristics of asthma include increased airway resistance and dynamic pulmonary hyperinflation that can manifest in dangerous levels of hypercapnia and acidosis, with significant mortality and morbidity. Severe respiratory distress can lead to endotracheal intubation followed by mechanical ventilation, which can cause increased air trapping with dynamic hyperinflation, predisposing the lungs to barotraumas.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>The present case report describes the use of the minimally invasive ECCO<jats:sub>2<\/jats:sub>R ProLUNG<jats:sup>\u00ae<\/jats:sup> (Estor) with protective low-tidal-volume ventilation, in a Caucasian patient with near-fatal asthma and with no response to conventional therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Since hypercarbia rather than hypoxemia is the primary abnormality in status asthmaticus, a rescue therapeutic strategy combining the ECCO<jats:sub>2<\/jats:sub>R membrane ProLUNG<jats:sup>\u00ae<\/jats:sup> (Estor) with ultra-protective low-tidal-volume ventilation can be successfully applied to limit the risk of severe barotrauma during invasive mechanical ventilation. ECCO<jats:sub>2<\/jats:sub>R ProLUNG<jats:sup>\u00ae<\/jats:sup> is a partial respiratory support technique that, based on the use of an extracorporeal circuit with a gas-exchange membrane, achieves relevant CO<jats:sub>2<\/jats:sub> clearance directly from the blood using double-lumen venous-venous vascular access, at blood flow in the range of 0.4\u20131.0 L\/minute.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02689-6","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T14:26:19Z","timestamp":1618410379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Decapneization as supportive therapy for the treatment of status asthmaticus: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Rossella","family":"Esposito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Imperatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Liguori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Gritti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cafora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo Francesco","family":"Marsilia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"De Cristofaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"2689_CR1","first-page":"101010","volume":"29","author":"S De Rosa","year":"2020","unstructured":"De Rosa S, Golino G. Extracorporeal carbon dioxide removal in heart-beating donor with acute severe asthma: a case report. Respir Med Case Rep. 2020;29:101010.","journal-title":"Respir Med Case Rep"},{"issue":"6","key":"2689_CR2","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1378\/chest.14-1733","volume":"147","author":"J Leatherman","year":"2015","unstructured":"Leatherman J. Mechanical ventilation for severe asthma. Chest. 2015;147(6):1671\u201380.","journal-title":"Chest."},{"issue":"3","key":"2689_CR3","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1183\/13993003.00853-2015","volume":"46","author":"H Reddel","year":"2015","unstructured":"Reddel H, Bateman E, Becker A, et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J. 2015;46(3):622\u201339.","journal-title":"Eur Respir J"},{"issue":"6","key":"2689_CR4","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1378\/chest.119.6.1913","volume":"119","author":"HA Werner","year":"2001","unstructured":"Werner HA. Status asthmaticus in children: a review. Chest. 2001;119(6):1913\u201329.","journal-title":"Chest"},{"issue":"1","key":"2689_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S1081-1206(10)61444-5","volume":"93","author":"TB Pendergraft","year":"2004","unstructured":"Pendergraft TB, Stanford RH. Rates and characteristics of intensive care unit admissions and intubations among asthma-related hospitalizations. Ann Allergy Asthma Immunol. 2004;93(1):29\u201335.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"7","key":"2689_CR6","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1164\/rccm.200208-902SO","volume":"168","author":"ER McFadden","year":"2003","unstructured":"McFadden ER. Acute severe asthma. Am J Respir Crit Care Med. 2003;168(7):740\u201359.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"2689_CR7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s12471-013-0383-1","volume":"21","author":"TGV Cherpanath","year":"2013","unstructured":"Cherpanath TGV, Lagrand WK, Schultz MJ, Groeneveld ABJ. Cardiopulmonary interactions during mechanical ventilation in critically ill patients. Neth Heart J. 2013;21(4):166\u201372.","journal-title":"Neth Heart J"},{"issue":"1","key":"2689_CR8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/MAT.0b013e3181901ea5","volume":"55","author":"ME Mikkelsen","year":"2009","unstructured":"Mikkelsen ME, Woo YJ, Sager JS, Fuchs BD, Christie JD. Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus. Am Soc Artif Intern Organs J. 2009;55(1):47\u201352.","journal-title":"Am Soc Artif Intern Organs J"},{"issue":"1","key":"2689_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/0267659113494964","volume":"29","author":"K Brenner","year":"2014","unstructured":"Brenner K, Abrams DC, Agerstrand CL, Brodie D. Extracorporeal carbon dioxide removal for refractory status asthmaticus: experience in distinct exacerbation phenotypes. Perfusion. 2014;29(1):26\u20138.","journal-title":"Perfusion"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02689-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-02689-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02689-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T16:16:31Z","timestamp":1620144991000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02689-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2689"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02689-6","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"19 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian(s) for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"200"}}