{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:40:38Z","timestamp":1782819638531,"version":"3.54.5"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Aripiprazole is a third-generation atypical antipsychotic drug that acts as a stabilizer of the dopaminergic and serotonergic system. As partial agonist of the dopamine (D2) and serotonin (5-HT1A)  receptors, it appears to be effective in reducing mania in patients with bipolar disorder, tics in Tourette Syndrome, aggression in schizophrenia and autism spectrum disorder. Enuresis has been reported among its side effects. Only a few studies, with conflicting results, have investigated the relationship between aripiprazole and enuresis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report the disappearance of enuresis in a Caucasian girl with intellectual disability and oppositional defiant disorder and in a Caucasian boy with intellectual disability and early-onset psychosis, both following initiation of treatment with aripiprazole.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The aim of this study was to contribute to the literature on the use of aripripazole in subjects with enuresis. Our findings lead us to suggest that aripiprazole is less burdened with side effects, including bedwetting, than other antipsychotic drugs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02691-y","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T10:11:12Z","timestamp":1618999872000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Resolution of enuresis with aripiprazole in children with psychiatric disorders: two case reports"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-6910","authenticated-orcid":false,"given":"Rosaria","family":"Nardello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Guccione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gliubizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarita","family":"Capizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Mangano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"2691_CR1","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1021\/acschemneuro.7b00087","volume":"8","author":"AB Casey","year":"2017","unstructured":"Casey AB, Canal CE. Classics in chemical neuroscience: Aripiprazole. ACS Chem Neurosci. 2017;8:1135\u201346.","journal-title":"ACS Chem Neurosci"},{"issue":"4","key":"2691_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/WNF.0000000000000223","volume":"40","author":"S Gunes","year":"2017","unstructured":"Gunes S. Aripiprazole-related diurnal enuresis in children: 2 cases (Aripiprazole-related enuresis). Clin Neuropharmacol. 2017;40(4):175\u20136.","journal-title":"Clin Neuropharmacol"},{"issue":"6","key":"2691_CR3","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1089\/cap.2015.0003","volume":"25","author":"MN Karakurt","year":"2015","unstructured":"Karakurt MN, S\u00fcren S. Desmopressin use in the treatment of aripiprazole-induced nocturnal enuresis in a child diagnosed with autistic disorder. J Child Adolesc Psychopharmacol. 2015;25(6):518\u20139.","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"4","key":"2691_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/WNF.0000000000000396","volume":"43","author":"S Karatoprak","year":"2020","unstructured":"Karatoprak S, Uzun N. Low-dose aripiprazole induced enuresis continuum in a child. Clin Neuropharmacol. 2020;43(4):123\u20134.","journal-title":"Clin Neuropharmacol"},{"key":"2691_CR5","first-page":"164","volume":"48","author":"H Bozkurt","year":"2011","unstructured":"Bozkurt H, Abali O. Aripiprazole-induced enuresis in a child with autistic disorder. Arch Neuropsychiatry. 2011;48:164\u20136.","journal-title":"Arch Neuropsychiatry"},{"issue":"2","key":"2691_CR6","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3346\/jkms.2010.25.2.333","volume":"25","author":"MJ Lee","year":"2010","unstructured":"Lee MJ, Kim CE. Use of aripiprazole in clozapine induced enuresis: report of two cases. J Korean Med Sc. 2010;25(2):333\u20135.","journal-title":"J Korean Med Sc"},{"issue":"2","key":"2691_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1089\/cap.2016.0127","volume":"27","author":"S K\u0131l\u0131n\u00e7","year":"2016","unstructured":"K\u0131l\u0131n\u00e7 S, Herg\u00fcner A, Herg\u00fcner S. Cessation of nocturnal enuresis with Aripiprazole. J Child Adolesc Psychopharmacol. 2016;27(2):213\u20134.","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"2691_CR8","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.schres.2006.01.023","volume":"84","author":"JT Kantrowitz","year":"2006","unstructured":"Kantrowitz JT, Srihari VH, Tek C. Three cases of risperidone-induced enuresis. Schizophr Res. 2006;84:174\u20135.","journal-title":"Schizophr Res"},{"key":"2691_CR9","doi-asserted-by":"publisher","first-page":"574","DOI":"10.4103\/0253-7613.165176","volume":"47","author":"P Palaniappan","year":"2015","unstructured":"Palaniappan P. Aripiprazole as a treatment option for clozapine-induced enuresis. Indian J Pharmacol. 2015;47:574\u20135.","journal-title":"Indian J Pharmacol"},{"issue":"2\u20133","key":"2691_CR10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.euf.2017.08.010","volume":"3","author":"B Haid","year":"2017","unstructured":"Haid B, Tekg\u00fcl S. Primary and secondary enuresis: pathophysiology, diagnosis, and treatment. Eur Urol Focus. 2017;3(2\u20133):198\u2013206.","journal-title":"Eur Urol Focus"},{"issue":"2\u20132","key":"2691_CR11","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3109\/15622970903369965","volume":"11","author":"DN Mendhekar","year":"2010","unstructured":"Mendhekar DN, Andrade C. Risperidone-related reversal of primary enuresis: an unusual case report. 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Written informed consent for publication was obtained from the patients\u2019 parents.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patients' legal guardians for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"209"}}