{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:57:46Z","timestamp":1788123466334,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sirenomelia, also called mermaid syndrome, is a rare lethal multi-system congenital deformity with an incidence of one in 60,000\u201370,000 pregnancies. Sirenomelia is mainly characterized by the fusion of lower limbs and is widely associated with severe urogenital and gastrointestinal malformations. The presence of a single umbilical artery derived from the vitelline artery is the main anatomical feature distinguishing sirenomelia from caudal regression syndrome. First-trimester diagnosis of this disorder and induced abortion may be the safest medical option. In this report, two cases of sirenomelia that occurred in an white family will be discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report two white cases of sirenomelia occurring in a 31-year-old multigravid pregnant woman. In the first pregnancy (18 weeks of gestation) abortion was performed, but in the third pregnancy (32 weeks) the stillborn baby was delivered by spontaneous vaginal birth. In the second and fourth pregnancies, however, she gave birth to normal babies. Three-dimensional ultrasound imaging showed fusion of the lower limbs. Neither she nor any member of her family had a history of diabetes. In terms of other risk factors, she had no history of exposure to teratogenic agents during her pregnancy. Also, her marriage was non-consanguineous.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report suggests the existence of a genetic background in this mother with a Mendelian inheritance pattern of 50% second-generation incidence in her offspring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-021-02699-4","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T09:04:18Z","timestamp":1619427858000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sirenomelia: two case\u00a0reports"],"prefix":"10.1186","volume":"15","author":[{"given":"Asiyeh","family":"Shojaee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firooze","family":"Ronnasian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdiyeh","family":"Behnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"issue":"3","key":"2699_CR1","doi-asserted-by":"publisher","first-page":"430","DOI":"10.5455\/2320-1770.ijrcog20130936","volume":"2","author":"L Sahu","year":"2013","unstructured":"Sahu L, Singh S, Gandhi G, Agarwal K. Sirenomelia: a case report with literature review. Int J Reprod Contracept Obstet Gynecol. 2013;2(3):430\u20132.","journal-title":"Int J Reprod Contracept Obstet Gynecol."},{"issue":"3","key":"2699_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1242\/dmm.007732","volume":"4","author":"C Garrido-Allepuz","year":"2011","unstructured":"Garrido-Allepuz C, Haro E, Gonzalez-Lamuno D, Martinez-Frias ML, Bertocchini F, Ros MA. A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations. Dis Model Mech. 2011;4(3):289\u201399.","journal-title":"Dis Model Mech."},{"issue":"7","key":"2699_CR3","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s00383-003-0992-7","volume":"20","author":"N Lutz","year":"2004","unstructured":"Lutz N, Meyrat BJ, Guignard J-P, Hohlfeld J. Mermaid syndrome: virtually no hope for survival. 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