{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:06:38Z","timestamp":1761491198265},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Previous studies have shown that patients who underwent renal transplantation were at a greater risk of developing malignancies. Due to advances in effective surgical techniques and immunosuppressive therapies, organ recipients live longer. Yet, there is insufficient information about the recommended type of therapy for colorectal cancer patients following transplantation. We describe the oncological treatment of a patient with renal transplantation, who presented with metastatic colon cancer 5 years after transplantation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 66-year-old Caucasian male patient, with hypertension, type 2 diabetes mellitus, paroxysmal atrial fibrillation, and renal failure underwent successful kidney transplantation in 2013. In April 2018, the adenocarcinoma of the sigmoid colon was found, and surgical resection was performed. The histological diagnosis was low-grade adenocarcinoma. Fluorodeoxyglucose positron emission tomography\/computerized tomography scan showed a 2.5-cm metastasis in the VIIth segment of the liver and a metastatic paraaortical lymph node on the left. The clinical diagnosis was, therefore, metastatic (stage IV) sigmoid colon cancer (AJCC TNM system). The ongoing medications of the patient included immunosuppressive drugs and medication for his cardiovascular comorbidities. In July 2018, palliative cetuximab plus folinic acid\u2013fluorouracil\u2013irinotecan chemotherapeutic treatment was initiated, then cetuximab was substituted for panitumumab because of adverse events. In August 2018, the follow-up positron emission tomography\/computerized tomography scan revealed stable disease. Because of side effects, the patient was unwilling to continue with the panitumumab plus folinic acid\u2013fluorouracil\u2013irinotecan treatment regimen. Therefore, the patient received 10\u00d7 5\u00a0Gy stereotactic body irradiation for his liver metastasis and mono-panitumumab therapy. By January 2019, the positron emission tomography\/computerized tomography scan showed regression of the liver metastasis but a progression in the paraaortic lymph node. Therefore, 5\u00d7 8\u00a0Gy stereotactic irradiation was given to the paraaortic lesion. Meanwhile, the patient received altogether 16 cycles of panitumumab until June 2019, when complete remission was attained. In July 2019, the patient suffered a hemorrhagic stroke, probably due to his cardiovascular comorbidities, and died subsequently.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Since information is scarce regarding oncological treatment of patients following organ transplantation, data about their oncological treatment is essential. To our knowledge, this is the first case report to describe the successful chemotherapy and targeted therapy supplemented with stereotactic radiotherapy of a posttransplant patient with metastatic colorectal cancer.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02702-y","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:15:07Z","timestamp":1616199307000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effective chemotherapy and targeted therapy supplemented with stereotactic radiotherapy of a patient with metastatic colon cancer following renal transplantation: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Szabolcs","family":"Bellyei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1rp\u00e1d","family":"Boronkai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Pozsgai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1vid","family":"Fodor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Mangel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"issue":"4","key":"2702_CR1","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","volume":"66","author":"M Arnold","year":"2017","unstructured":"Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683\u201391.","journal-title":"Gut"},{"issue":"10","key":"2702_CR2","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.1016\/j.transproceed.2018.07.031","volume":"50","author":"A Balhareth","year":"2018","unstructured":"Balhareth A, Reynolds IS, Solon JG, Harte EG, Boland F, O\u2019Sullivan JM, et\u00a0al. Thirty-seven-year population-based study of colorectal cancer rates in renal transplant recipients in Ireland. Transplant Proc. 2018;50(10):3434\u20139.","journal-title":"Transplant Proc."},{"issue":"2","key":"2702_CR3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","volume":"140","author":"EJ Park","year":"2010","unstructured":"Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et\u00a0al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010;140(2):197\u2013208.","journal-title":"Cell"},{"issue":"4","key":"2702_CR4","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1097\/00007890-199304000-00011","volume":"55","author":"I Penn","year":"1993","unstructured":"Penn I. The effect of immunosuppression on pre-existing cancers. Transplantation. 1993;55(4):742\u20137.","journal-title":"Transplantation"},{"key":"2702_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-018-5219-3","volume":"19","author":"HE Wang","year":"2019","unstructured":"Wang HE, Liao YC, Hu JM, Wu WC, Chou WY, Chen YC, et\u00a0al. Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study. BMC Cancer. 2019;19:1.","journal-title":"BMC Cancer."},{"issue":"4","key":"2702_CR6","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1016\/S0041-1345(03)00478-0","volume":"35","author":"RF Saidi","year":"2003","unstructured":"Saidi RF, Dudrick PS, Goldman MH. Colorectal cancer after renal transplantation. Transplant Proc. 2003;35(4):1410\u20132.","journal-title":"Transplant Proc."},{"key":"2702_CR7","doi-asserted-by":"crossref","unstructured":"Demir T, Ozel L, G\u00f6k\u00e7e AM, Ata P, Kara M, Eri\u015f C, et\u00a0al. Cancer screening of renal transplant patients undergoing long-term immunosuppressive therapy. In: Transplant Proc. New York: Elsevier; 2015. p. 1413\u20137.","DOI":"10.1016\/j.transproceed.2015.04.073"},{"issue":"1","key":"2702_CR8","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1523-1755.2004.00741.x","volume":"66","author":"ML Agraharkar","year":"2004","unstructured":"Agraharkar ML, Cinclair RD, Kuo YF, Daller JA, Shahinian VB. Risk of malignancy with long-term immunosuppression in renal transplant recipients. Kidney Int. 2004;66(1):383\u20139.","journal-title":"Kidney Int."},{"key":"2702_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tipsro.2018.04.001","volume":"7","author":"M Mast","year":"2018","unstructured":"Mast M, Kouwenhoven E, Roos J, van Geen S, van Egmond J, van Santvoort J, et\u00a0al. Two years\u2019 experience with inspiration breath-hold in liver SBRT. Tech Innov Patient Support Radiat Oncol. 2018;7:1\u20135.","journal-title":"Tech Innov Patient Support Radiat Oncol."},{"issue":"15","key":"2702_CR10","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.3748\/wjg.v17.i15.2058","volume":"17","author":"HY Liu","year":"2011","unstructured":"Liu HY, Liang XB, Li YP, Feng Y, Liu DB, Da WW. Treatment of advanced rectal cancer after renal transplantation. World J Gastroenterol. 2011;17(15):2058\u201360.","journal-title":"World J Gastroenterol."},{"issue":"3","key":"2702_CR11","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2337\/dc14-1175","volume":"38","author":"PJHL Peeters","year":"2015","unstructured":"Peeters PJHL, Bazelier MT, Leufkens HGM, De Vries F, De Bruin ML. The risk of colorectal cancer in patients with type 2 diabetes: associations with treatment stage and obesity. Diabetes Care. 2015;38(3):495\u2013502.","journal-title":"Diabetes Care"},{"key":"2702_CR12","doi-asserted-by":"crossref","unstructured":"Fang W. Chemotherapy in patient with colon cancer after renal transplantation: a case report with literature review. Medicine (Baltimore).. Vol. 97, Medicine (United States). Lippincott Williams and Wilkins; 2018","DOI":"10.1097\/MD.0000000000009678"},{"issue":"8","key":"2702_CR13","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/annonc\/mdx175","volume":"28","author":"D Arnold","year":"2017","unstructured":"Arnold D, Lueza B, Douillard JY, Peeters M, Lenz HJ, Venook A, et\u00a0al. Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials. Ann Oncol. 2017;28(8):1713\u201329.","journal-title":"Ann Oncol."},{"key":"2702_CR14","doi-asserted-by":"crossref","unstructured":"Tejpar S, Stintzing S, Ciardiello F, Tabernero J, Van Cutsem E, Beier F, et\u00a0al. Prognostic and predictive relevance of primary tumor location in patients with ras wild-type metastatic colorectal cancer retrospective analyses of the CRYSTAL and FIRE-3 trials. In: JAMA Oncol. American Medical Association; 2017. p. 194\u2013201.","DOI":"10.1001\/jamaoncol.2016.3797"},{"issue":"13","key":"2702_CR15","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1158\/1078-0432.CCR-08-0077","volume":"14","author":"B Vincenzi","year":"2008","unstructured":"Vincenzi B, Santini D, Galluzzo S, Russo A, Fulfaro F, Silletta M, et\u00a0al. Early magnesium reduction in advanced colorectal cancer patients treated with cetuximab plus irinotecan as predictive factor of efficacy and outcome. Clin Cancer Res. 2008;14(13):4219\u201324.","journal-title":"Clin Cancer Res."},{"issue":"4","key":"2702_CR16","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/annonc\/mds577","volume":"24","author":"MM Vickers","year":"2013","unstructured":"Vickers MM, Karapetis CS, Tu D, O\u2019Callaghan CJ, Price TJ, Tebbutt NC, et\u00a0al. Association of hypomagnesemia with inferior survival in a phase III, randomized study of cetuximab plus best supportive care versus best supportive care alone: NCIC CTG\/AGITG CO17. Ann Oncol. 2013;24(4):953\u201360.","journal-title":"Ann Oncol."},{"issue":"15","key":"2702_CR17","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.3748\/wjg.v20.i15.4220","volume":"20","author":"A Takeda","year":"2014","unstructured":"Takeda A, Sanuki N, Kunieda E. Role of stereotactic body radiotherapy for oligometastasis from colorectal cancer. World J Gastroenterol. 2014;20(15):4220\u20139.","journal-title":"World J Gastroenterol."},{"issue":"11","key":"2702_CR18","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1056\/NEJMoa1305275","volume":"369","author":"JY Douillard","year":"2013","unstructured":"Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, et\u00a0al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369(11):1023\u201334.","journal-title":"N Engl J Med."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02702-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-021-02702-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02702-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:34:33Z","timestamp":1616200473000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02702-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,20]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2702"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02702-y","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,20]]},"assertion":[{"value":"12 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethics committee approval was obtained from the Regional Ethical Committee (Reference number: 7532-PTE2019).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s relative for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"125"}}