{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:17:56Z","timestamp":1775063876539,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Paraneoplastic neurological syndrome is an immune-mediated phenomenon where antibodies from tumor cells are produced against neuronal proteins. Amphiphysin antibody is an onconeural antibody linked to the diagnosis of breast cancer and small-cell lung cancer. It is uncommon and typically associated with stiff-person syndrome, of which 90% of patients are eventually diagnosed with breast cancer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a case of a 47-year-old Caucasian woman with metastatic hormone receptor-positive breast cancer who developed bilateral facial nerve palsy while on treatment with nab-paclitaxel. The patient was found to have anti-amphiphysin antibody in the serum and cerebrospinal fluid. She was treated with methylprednisolone and intravenous immunoglobulin, which resulted in partial improvement in her facial nerve palsy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case highlights a rare presentation of bilateral facial nerve palsy that likely related to paraneoplastic syndrome associated with the presence of anti-amphiphysin antibody.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02727-3","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:06:05Z","timestamp":1616717165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-4056","authenticated-orcid":false,"given":"Vineet","family":"Kwatra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail","family":"Charakidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayan V.","family":"Karanth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"2727_CR1","first-page":"447","volume-title":"European Handbook of Neurological Management","author":"CA Vedeler","year":"2011","unstructured":"Vedeler CA, Antoine JC, Giometto B, et\u00a0al. Paraneoplastic neurological syndromes. In: Gilhus NE, Barnes MP, Brainin M, editors., et\u00a0al., European Handbook of Neurological Management. 2nd ed. Blackwell Publishing Ltd: Oxford; 2011. p. 447\u201357.","edition":"2"},{"key":"2727_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1750-1172-2-22","volume":"2","author":"J Honnorat","year":"2007","unstructured":"Honnorat J, Antoine JC. Paraneoplastic neurological syndromes. Orphanet J Rare Dis. 2007;2:22.","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"2727_CR3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4103\/0972-2327.93267","volume":"15","author":"S Kannoth","year":"2012","unstructured":"Kannoth S. Paraneoplastic neurologic syndrome: a practical approach. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"158"}}