{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T09:25:10Z","timestamp":1746696310197},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf. Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Metastatic spread to the pancreas is a rare event. Renal cell carcinoma represents one possible site of origin of pancreatic metastases. Renal cell carcinoma often metastasizes late and exclusively to the pancreas, suggesting a special role of renal cell carcinoma among primaries metastasizing to the pancreas. Even rarer, renal cell carcinoma may occur simultaneously with pancreatic ductal adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We present the case of a 78-year-old male Caucasian patient with a history of clear-cell renal cell carcinoma treated with oncological left nephrectomy 20 years before. The patient was diagnosed with pancreatic ductal adenocarcinoma by fine-needle aspiration cytology. At our institution, he received neoadjuvant therapy with folic acid, fluorouracil, irinotecan, oxaliplatin for borderline-resectable pancreatic ductal adenocarcinoma, and subsequently underwent total pancreatectomy. Upon resection, pancreatic ductal adenocarcinoma as well as two metachronous metastases of clear-cell renal cell carcinoma occurring simultaneously and cospatially with pancreatic ductal adenocarcinoma were diagnosed in the pancreatic body.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Renal cell carcinoma metastases of the pancreas are rare and often occur decades after the initial diagnosis of renal cell carcinoma. The combination of renal cell carcinoma metastases and pancreatic ductal adenocarcinoma is even rarer. However, the possibility should be considered by clinicians, radiologists, and pathologists. The special role of renal cell carcinoma as a site of origin of pancreatic metastasis should be further elucidated.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13256-021-02768-8","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T13:09:14Z","timestamp":1622466554000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pancreatic ductal adenocarcinoma concomitant with pancreatic metastases of clear-cell renal cell carcinoma: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Lena","family":"Haeberle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Busch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Kirchner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Fluegen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Antoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram Trudo","family":"Knoefel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"2768_CR1","doi-asserted-by":"crossref","unstructured":"Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas: In: AFIP Atlas of Tumor Pathology, series 4, fascicle 6. Washington, DC; 2007.","DOI":"10.55418\/9781933477022"},{"key":"2768_CR2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.pan.2018.04.010","volume":"18","author":"CS Verbeke","year":"2018","unstructured":"Verbeke CS, Haeberle L, Lenggenhager D, Esposito I. Pathology assessment of pancreatic cancer following neoadjuvant treatment: time to move on. Pancreatology. 2018;18:467\u201376.","journal-title":"Pancreatology"},{"key":"2768_CR3","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00428-004-0987-3","volume":"444","author":"NV Adsay","year":"2004","unstructured":"Adsay NV, Andrea A, Basturk O, Kilinc N, Nassar H, Cheng JD. Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature. 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Eur J Surg Oncol. 2014;40:379\u201386.","journal-title":"Eur J Surg Oncol"},{"key":"2768_CR6","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/01.mpa.0000153337.58105.47","volume":"30","author":"MN Wente","year":"2005","unstructured":"Wente MN, Kleeff J, Esposito I, Hartel M, M\u00fcller MW, Fr\u00f6hlich BE, et\u00a0al. Renal cancer cell metastasis into the pancreas: a single-center experience and overview of the literature. Pancreas. 2005;30:218\u201322.","journal-title":"Pancreas"},{"key":"2768_CR7","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.3390\/cancers11091379","volume":"11","author":"F Sellner","year":"2019","unstructured":"Sellner F. Observations on solitary versus multiple isolated pancreatic metastases of renal cell carcinoma: another indication of a seed and soil mechanism? Cancers (Basel). 2019;11:1379.","journal-title":"Cancers (Basel)"},{"key":"2768_CR8","doi-asserted-by":"crossref","unstructured":"Singla N, Xie Z, Zhang Z, Gao M, Yousuf Q, Onabolu O, et\u00a0al. Pancreatic tropism of metastatic renal cell carcinoma. JCI Insight. 2020;5:e134564.","DOI":"10.1172\/jci.insight.134564"},{"key":"2768_CR9","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1111\/j.1464-410X.2006.06004.x","volume":"97","author":"C Beisland","year":"2006","unstructured":"Beisland C, Talleraas O, Bakke A, Norstein J. Multiple primary malignancies in patients with renal cell carcinoma: a national population-based cohort study. BJU Int. 2006;97:698\u2013702.","journal-title":"BJU Int"},{"key":"2768_CR10","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s11912-009-0015-5","volume":"11","author":"CL Cowey","year":"2010","unstructured":"Cowey CL, Rathmell WK. VHL gene mutations in renal cell carcinoma: role as biomarker of disease outcome and drug efficacy. 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No experimental treatment was applied.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the next of kin of the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"314"}}