{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T21:17:15Z","timestamp":1771190235622,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Composite lymphoma is a rare entity where two or more distinct subtypes of lymphoma coexist within a single organ or tissue.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a new case of a 67-year-old Caucasian male patient, who presented with fatigue, weakness, weight loss, and polyuria. He also had epigastric and left lumbar pain, enlarged spleen, and enlarged left axillary lymph node on examination, with no relevant medical or familial history.<\/jats:p>\n                <jats:p>A biopsy from the node showed an appearance of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma.<\/jats:p>\n                <jats:p>The patient was initially treated with adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine chemotherapy regimen, then switched to rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone regimen.<\/jats:p>\n                <jats:p>During the therapy, some regression was noticed, especially in the size of the splenic enlargement; however, the patient died 2 months after completing the regimen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Composite lymphomas should continue to be studied. Also, treatment is still debatable in type, efficacy, and outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02783-9","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T23:21:08Z","timestamp":1618356068000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Composite lymphoma of T-cell rich, histiocyte-rich diffuse large B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-5517","authenticated-orcid":false,"given":"Asil","family":"Esper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-3308","authenticated-orcid":false,"given":"Sami","family":"Alhoulaiby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruba","family":"Zuhri Yafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuheir","family":"Alshehabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"2783_CR1","unstructured":"RP C. Pitfalls in the diagnosis of lymphoma and leukemia from pathologist\u2019s point of view. In: Proceedings of second national conference. New York American Cancer Society. 1954;554\u2013557."},{"issue":"3","key":"2783_CR2","first-page":"171","volume":"19","author":"NM Mokhtar","year":"2007","unstructured":"Mokhtar NM. Review article composite lymphoma. J Egypt Natl Cancer Inst. 2007;19(3):171\u20135.","journal-title":"J Egypt Natl Cancer Inst"},{"issue":"9","key":"2783_CR3","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.5858\/2000-124-1376-AUVOCL","volume":"124","author":"S Thirumala","year":"2000","unstructured":"Thirumala S, Esposito M, Fuchs A. An unusual variant of composite lymphoma: a short case report and review of the literature. Arch Pathol Lab Med. 2000;124(9):1376\u20138.","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"2783_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/ajcp\/99.4.445","volume":"99","author":"H Kim","year":"1993","unstructured":"Kim H. Composite lymphoma and related disorders. Am J Clin Pathol. 1993;99(4):445\u201351.","journal-title":"Am J Clin Pathol"},{"key":"2783_CR5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1746-1596-6-60","volume":"6","author":"G Yu","year":"2011","unstructured":"Yu G, Kong L, Qu G, Zhang Q, Wang W, Jiang L. Composite lymphoma in the anterior mediastinum: a case report and review of the literature. Diagn Pathol. 2011;6:60.","journal-title":"Diagn Pathol"},{"issue":"4","key":"2783_CR6","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1634\/theoncologist.11-4-384","volume":"11","author":"JS Abramson","year":"2006","unstructured":"Abramson JS. T-cell\/histiocyte-rich B-cell lymphoma: biology, diagnosis, and management. Oncologist. 2006;11(4):384\u201392.","journal-title":"Oncologist"},{"issue":"3","key":"2783_CR7","first-page":"83","volume":"102","author":"SH Swerdlow","year":"2017","unstructured":"Swerdlow SH, Campo E, Lee NH, Jaffe ES. WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview. Pathologica. 2017;102(3):83\u20137.","journal-title":"Pathologica"},{"issue":"10","key":"2783_CR8","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.5858\/2010-0207-OA.1","volume":"134","author":"LB Smith","year":"2010","unstructured":"Smith LB. Nodular lymphocyte predominant Hodgkin lymphoma: diagnostic pearls and pitfalls. Arch Pathol Lab Med. 2010;134(10):1434\u20139.","journal-title":"Arch Pathol Lab Med"},{"issue":"5","key":"2783_CR9","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1177\/1066896911405656","volume":"19","author":"AK Ho","year":"2011","unstructured":"Ho AK, Teman CJ, Smith GP, Nightingale DR, Miles RR. Composite mantle cell and diffuse large B-cell lymphoma: report of two cases. Int J Surg Pathol. 2011;19(5):643\u20138.","journal-title":"Int J Surg Pathol"},{"issue":"1","key":"2783_CR10","first-page":"34","volume":"101","author":"WD Lewis","year":"2020","unstructured":"Lewis WD, Lilly S, Jones KL. Lymphoma: diagnosis and treatment. Am Fam Phys. 2020;101(1):34\u201341.","journal-title":"Am Fam Phys"},{"issue":"1","key":"2783_CR11","first-page":"e963","volume":"9","author":"F Mohammad","year":"2017","unstructured":"Mohammad F, Garcia G, Kedia S, Ding J, Hurford M, Bershadskiy A. Composite diffuse large B-cell and mantle cell lymphoma: a case report. Cureus. 2017;9(1):e963.","journal-title":"Cureus"},{"issue":"4","key":"2783_CR12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1182\/blood-2017-05-786301","volume":"130","author":"DA Eichenauer","year":"2017","unstructured":"Eichenauer DA, Engert A. R-CHOP in NLPHL: who should receive it? Blood. 2017;130(4):387\u20138.","journal-title":"Blood"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02783-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-02783-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02783-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T03:26:59Z","timestamp":1618630019000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02783-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2783"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02783-9","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]},"assertion":[{"value":"1 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"163"}}