{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:24:11Z","timestamp":1762543451694},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Patients with pulmonary sarcoidosis commonly present with a dry cough; a productive cough suggests a complicating airway infection or an alternative diagnosis such as tuberculosis or bronchiectasis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 36-year-old European (Frisian) woman recently diagnosed with pulmonary sarcoidosis presented with debilitating exertional dyspnea and cough productive of glazy mucoid sputum. Several different attempts including video-assisted thoracoscopic biopsies failed to reach a second or alternative diagnosis including an infectious, autoimmune or collagen-vascular condition. She responded to steroids but with poor tolerance to this treatment, which could not be tapered. After she was started on anti-tumor necrosis factor alpha (TNF-\u03b1) therapy with infliximab, 200 mg at three-monthly intervals, she has been fine for well over a decade.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In this patient with sarcoidosis who had a productive cough accompanied by fever, an extensive workup and prolonged follow-up, an alternative or second diagnosis could be ruled out; we therefore conclude that this highly unusual presentation is part of the clinical spectrum of sarcoidosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02809-2","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T23:05:59Z","timestamp":1620687959000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sarcoidosis presenting with glazy mucoid sputum and dyspnea: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Wud","family":"Al-Kailany","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Timens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Venmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonda","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjip S.","family":"van der Werf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"issue":"21","key":"2809_CR1","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1056\/NEJMra071714","volume":"357","author":"MC Iannuzzi","year":"2007","unstructured":"Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007;357(21):2153\u201365.","journal-title":"N Engl J Med"},{"key":"2809_CR2","doi-asserted-by":"publisher","first-page":"594275","DOI":"10.3389\/fmed.2020.594275","volume":"7","author":"N Narula","year":"2020","unstructured":"Narula N, Iannuzzi M. Sarcoidosis: pitfalls and challenging mimickers. Front Med (Lausanne). 2020;7:594275.","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"2809_CR3","first-page":"158","volume":"37","author":"BS Gvozdenovic","year":"2020","unstructured":"Gvozdenovic BS, Mihailovic-Vucinic VV, Vukovic MH, et al. Predictors of cough-specific and generic quality of life in sarcoidosis patients. Sarcoidosis Vasc Diffuse Lung Dis. 2020;37(2):158\u201368.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"issue":"4","key":"2809_CR4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1001\/jama.2011.10","volume":"305","author":"MC Iannuzzi","year":"2011","unstructured":"Iannuzzi MC, Fontana JR. Sarcoidosis: clinical presentation, immunopathogenesis, and therapeutics. JAMA. 2011;305(4):391\u20139.","journal-title":"JAMA"},{"issue":"04","key":"2809_CR5","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1055\/s-0030-1262218","volume":"31","author":"CA Lazar","year":"2010","unstructured":"Lazar CA, Culver DA. Treatment of sarcoidosis. Semin Respir Crit Care Med. 2010;31(04):501\u201318.","journal-title":"Semin Respir Crit Care Med"},{"issue":"7","key":"2809_CR6","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1164\/rccm.200603-402OC","volume":"174","author":"RP Baughman","year":"2006","unstructured":"Baughman RP, Drent M, Kavuru M, et al. Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement. Am J Respir Crit Care Med. 2006;174(7):795\u2013802.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"2809_CR7","doi-asserted-by":"publisher","first-page":"425","DOI":"10.2165\/00063030-200317060-00005","volume":"17","author":"RP Baughman","year":"2003","unstructured":"Baughman RP, Iannuzzi M. Tumour necrosis factor in sarcoidosis and its potential for targeted therapy. BioDrugs. 2003;17(6):425\u201331.","journal-title":"BioDrugs"},{"issue":"5","key":"2809_CR8","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.rmed.2007.08.014","volume":"102","author":"AA Raj","year":"2008","unstructured":"Raj AA, Birring SS, Green R, Grant A, Caestecker J, Pavord ID. Prevalence of inflammatory bowel disease in patients with airways disease. Respir Med. 2008;102(5):780\u20135.","journal-title":"Respir Med"},{"issue":"2","key":"2809_CR9","first-page":"94","volume":"21","author":"V Poletti","year":"2004","unstructured":"Poletti V, Chilosi M, Casoni G, Colby TV. Diffuse panbronchiolitis. Sarcoidosis Vasc Diffuse Lung Dis. 2004;21(2):94\u2013104.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"issue":"13","key":"2809_CR10","first-page":"579","volume":"88","author":"S Lauper","year":"1999","unstructured":"Lauper S. Productive cough in established sarcoidosis. Praxis (Bern 1994). 1999;88(13):579\u201382.","journal-title":"Praxis (Bern 1994)"},{"issue":"6","key":"2809_CR11","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.semarthrit.2018.10.005","volume":"48","author":"BL Adler","year":"2019","unstructured":"Adler BL, Wang CJ, Bui T-L, Schilperoort HM, Armstrong AW. Anti-tumor necrosis factor agents in sarcoidosis: a systematic review of efficacy and safety. Semin Arthritis Rheum. 2019;48(6):1093\u2013104.","journal-title":"Semin Arthritis Rheum"},{"issue":"8","key":"2809_CR12","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1513\/AnnalsATS.201511-760OC","volume":"13","author":"RP Baughman","year":"2016","unstructured":"Baughman RP, Field S, Costabel U, et al. Sarcoidosis in America. Analysis based on health care use. Ann Am Thorac Soc. 2016;13(8):1244\u201352.","journal-title":"Ann Am Thorac Soc"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02809-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-02809-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02809-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:20:37Z","timestamp":1620692437000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02809-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,11]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2809"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02809-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,11]]},"assertion":[{"value":"22 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None declared.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"232"}}