{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:14:39Z","timestamp":1740147279266,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Alzheimer\u2019s disease is a neurodegenerative disease involving the deposition of pathologic amyloid-\u03b2 and tau protein in the cerebral cortex. Alzheimer\u2019s disease is commonly characterized by progressive impairment of recent memory. Primary progressive aphasia is also often observed in patients with Alzheimer\u2019s disease. Moreover, language-associated symptoms, such as primary progressive aphasia, are diverse and varied in Alzheimer\u2019s disease. However, nonfluent\/agrammatic variant primary progressive aphasia is not generally considered a symptom of Alzheimer\u2019s disease. To date, there has been no longitudinal study of primary progressive aphasia in Japanese-speaking patients or in patients speaking other languages with pathologically diagnosed Alzheimer\u2019s disease. Here we present a longitudinal study of primary progressive aphasia in a Japanese patient pathologically diagnosed with Alzheimer\u2019s disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 75-year-old Japanese man, whose wife reported that his memory was impaired, also suffered from suspected aphasia. He was pathologically diagnosed with Alzheimer\u2019s disease using <jats:sup>11<\/jats:sup>C-Pittsburgh compound-B positron emission tomography and <jats:sup>18<\/jats:sup>F-THK5351 positron emission tomography. Based on clinical observation and the results of the Japanese standard language test of aphasia, he was also diagnosed with nonfluent\/agrammatic variant primary progressive aphasia. During the subsequent 2\u00a0years, his cognitive impairment, aphasia, and behavioral and psychological symptoms of dementia progressed. Furthermore, progression of pathologic amyloid-\u03b2 and tau protein deposition was revealed through <jats:sup>11<\/jats:sup>C-Pittsburgh compound-B positron emission tomography and <jats:sup>18<\/jats:sup>F-THK5351 positron emission tomography. Although the results of [<jats:sup>123<\/jats:sup>I] iodoamphetamine single-photon emission computed tomography suggested corticobasal degeneration, this was not observed on the [<jats:sup>123<\/jats:sup>I] FP-CIT single-photon emission computed tomography (SPECT) (DaTscan). A previous study had reported that Alzheimer\u2019s disease with a nonfluent\/agrammatic variant primary progressive aphasia was accompanied by corticobasal degeneration; however, this was not true in our case.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This is possibly the first longitudinal study of nonfluent\/agrammatic variant primary progressive aphasia in a Japanese-speaking patient with pathologically diagnosed Alzheimer\u2019s disease, but without corticobasal degeneration.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02867-6","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T23:07:16Z","timestamp":1621984036000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal study of primary progressive aphasia in a patient with pathologically diagnosed Alzheimer\u2019s disease: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1450-4173","authenticated-orcid":false,"given":"Masahiko","family":"Takaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Saigoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Shirakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"issue":"11","key":"2867_CR1","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","volume":"76","author":"ML Gorno-Tempini","year":"2011","unstructured":"Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006\u201314.","journal-title":"Neurology"},{"issue":"3","key":"2867_CR2","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/ana.24885","volume":"81","author":"EG Spinelli","year":"2017","unstructured":"Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, et al. Typical and atypical pathology in primary progressive aphasia variants. Ann Neurol. 2017;81(3):430\u201343.","journal-title":"Ann Neurol."},{"key":"2867_CR3","volume-title":"Japanese Raven's Coloured Progressive Matrices","author":"M Sugishita","year":"1993","unstructured":"Sugishita M, Kumiko Y. Japanese Raven\u2019s Coloured Progressive Matrices. Tokyo: Nihon Bunka Kagakusha; 1993."},{"issue":"1","key":"2867_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13256-019-2338-7","volume":"14","author":"M Takaya","year":"2020","unstructured":"Takaya M, Ishii K, Kubota I, Shirakawa O. The Landscape Montage Technique for diagnosing frontotemporal dementia starting as primary progressive aphasia: a case report. J Med Case Rep. 2020;14(1):5.","journal-title":"J Med Case Rep."},{"key":"2867_CR5","doi-asserted-by":"crossref","unstructured":"Ota M, Koshibe Y, Higashi S, Nemoto K, Tsukada E, Tamura M, et al. Structural brain network correlated with reading impairment in Alzheimer's Disease. Dement Geriatr Cogn Disord. 2020; pp. 1-6.","DOI":"10.1159\/000508406"},{"key":"2867_CR6","volume-title":"Fifth Edition (DSM-5)","author":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013","unstructured":"Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition (DSM-5). American Psychiatric Association: Washington DC; 2013."},{"issue":"5","key":"2867_CR7","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","volume":"80","author":"MJ Armstrong","year":"2013","unstructured":"Armstrong MJ, Litvan I, Lang AE, Bak TH, Bhatia KP, Borroni B, et al. Criteria for the diagnosis of corticobasal degeneration. Neurology. 2013;80(5):496\u2013503.","journal-title":"Neurology"},{"issue":"3","key":"2867_CR8","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement. 2011;7(3):263\u20139.","journal-title":"Alzheimers Dement."},{"issue":"5","key":"2867_CR9","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1017\/S1041610217002277","volume":"30","author":"M Takaya","year":"2018","unstructured":"Takaya M, Ishii K, Hosokawa C, Saigoh K, Shirakawa O. Tau accumulation in two patients with frontotemporal lobe degeneration showing different types of aphasia using 18F-THK-5351 positron emission tomography: a case report. Int Psychogeriatr. 2018;30(5):641\u20136.","journal-title":"Int Psychogeriatr."},{"issue":"4","key":"2867_CR10","doi-asserted-by":"publisher","first-page":"907","DOI":"10.3233\/JPD-150625","volume":"5","author":"S Pirker","year":"2015","unstructured":"Pirker S, Perju-Dumbrava L, Kovacs GG, Traub-Weidinger T, Pirker W. Progressive dopamine transporter binding loss in autopsy-confirmed corticobasal degeneration. J Parkinsons Dis. 2015;5(4):907\u201312.","journal-title":"J Parkinsons Dis."},{"key":"2867_CR11","doi-asserted-by":"crossref","unstructured":"Devaraj NK, Suppiah S, Veettil SK, Ching SM, Lee KW, Menon RK, et al. The Effects of Probiotic Supplementation on the Incidence of Diarrhea in Cancer Patients Receiving Radiation Therapy: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. Nutrients. 2019;11(12).","DOI":"10.3390\/nu11122886"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02867-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-02867-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02867-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T23:23:38Z","timestamp":1621985018000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02867-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2867"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02867-6","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2021,5,26]]},"assertion":[{"value":"30 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient's legal guardian for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"272"}}