{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:31:21Z","timestamp":1788654681972,"version":"build-2803163510"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>High-dose vitamin C is increasingly used for sepsis and more recently for coronavirus disease 2019 (COVID-19) infections. Proponents argue that the low cost and near perfect safety profile of vitamin C support its early adoption. Yet, adverse events might be underreported and underappreciated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a 73-year-old non-diabetic white man with end-stage renal disease on peritoneal dialysis admitted to the intensive care unit with septic shock that was suspected to be due to peritonitis. The patient was enrolled in LOVIT (Lessening Organ Dysfunction with VITamin C; ClinicalTrials.gov identifier: NCT03680274), a randomized placebo-controlled trial of high-dose intravenous vitamin C. He developed factitious hyperglycemia, as measured with a point-of-care glucometer, that persisted for 6 days after discontinuation of the study drug, confirmed to be vitamin C after unblinding. He also had short-lived iatrogenic coma because of hypoglycemia secondary to insulin administration. These events triggered a protocol amendment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Although factitious hyperglycemia has been reported before using certain glucometers in patients treated with high-dose vitamin C, the persistence of this phenomenon for 6 days after the discontinuation of the therapy is a distinguishing feature. This case highlights the importance of monitoring glucose with a core laboratory assay for up to a week in specific populations, such as patients on peritoneal dialysis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02869-4","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T17:02:42Z","timestamp":1621616562000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High-dose vitamin-C induced prolonged factitious hyperglycemia in a peritoneal dialysis patient: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-0029","authenticated-orcid":false,"given":"Olivier","family":"Lachance","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Goyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill K. J.","family":"Adhikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Masse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Bilodeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lamontagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Andr\u00e9","family":"Leclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"issue":"6","key":"2869_CR1","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.chest.2016.11.036","volume":"151","author":"PE Marik","year":"2017","unstructured":"Marik PE, et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study. Chest. 2017;151(6):1229\u201338.","journal-title":"Chest"},{"key":"2869_CR2","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1001\/jama.2019.22176","volume":"323","author":"T Fujii","year":"2020","unstructured":"Fujii T, et al. Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS randomized clinical trial. JAMA. 2020;323:423.","journal-title":"JAMA"},{"issue":"13","key":"2869_CR3","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1001\/jama.2019.11825","volume":"322","author":"AA Fowler 3rd","year":"2019","unstructured":"Fowler AA 3rd, et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA. 2019;322(13):1261\u201370.","journal-title":"JAMA"},{"issue":"2","key":"2869_CR4","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1097\/BCR.0000000000000141","volume":"36","author":"SA Kahn","year":"2015","unstructured":"Kahn SA, Lentz CW. Fictitious hyperglycemia: point-of-care glucose measurement is inaccurate during high-dose vitamin C infusion for burn shock resuscitation. J Burn Care Res. 2015;36(2):e67-71.","journal-title":"J Burn Care Res"},{"issue":"5","key":"2869_CR5","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3349\/ymj.2013.54.5.1289","volume":"54","author":"SK Kim","year":"2013","unstructured":"Kim SK, et al. Spurious elevation of glucose concentration during administration of high dose of ascorbic acid in a patient with type 2 diabetes on hemodialysis. Yonsei Med J. 2013;54(5):1289\u201392.","journal-title":"Yonsei Med J"},{"key":"2869_CR6","unstructured":"MAUDE Adverse Event Report: ROCHE DIAGNOSTICS ACCU-CHEK \u00ae INFORM II TEST STRIPS BLOOD GLUCOSE MONITORING TEST STRIPS. 2017. https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfMAUDE\/detail.cfm?mdrfoi__id=6767309&pc=LFR."},{"key":"2869_CR7","unstructured":"Peng, Z. Vitamin C infusion for the treatment of severe 2019-nCoV Infected Pneumonia. 2020. NCT04264533. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04264533?id=NCT04264533&draw=2&rank=1&load=cart."},{"issue":"3","key":"2869_CR8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3343\/alm.2016.36.3.271","volume":"36","author":"J Cho","year":"2016","unstructured":"Cho J, et al. Influence of vitamin C and maltose on the accuracy of three models of glucose meters. Ann Lab Med. 2016;36(3):271\u20134.","journal-title":"Ann Lab Med"},{"issue":"1","key":"2869_CR9","first-page":"28","volume":"3","author":"SH Morgan","year":"1988","unstructured":"Morgan SH, et al. Oxalate metabolism in end-stage renal disease: the effect of ascorbic acid and pyridoxine. Nephrol Dial Transplant. 1988;3(1):28\u201332.","journal-title":"Nephrol Dial Transplant"},{"key":"2869_CR10","doi-asserted-by":"publisher","first-page":"S304","DOI":"10.1046\/j.1523-1755.2001.59780304.x","volume":"78","author":"M Mydlik","year":"2001","unstructured":"Mydlik M, Derzsiova K. Renal replacement therapy and secondary hyperoxalemia in chronic renal failure. Kidney Int Suppl. 2001;78:S304\u20137.","journal-title":"Kidney Int Suppl"},{"issue":"7415","key":"2869_CR11","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1136\/bmj.327.7415.608","volume":"327","author":"SG Riley","year":"2003","unstructured":"Riley SG, et al. Spurious hyperglycaemia and icodextrin in peritoneal dialysis fluid. BMJ. 2003;327(7415):608\u20139.","journal-title":"BMJ"},{"issue":"2","key":"2869_CR12","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1177\/1932296814563351","volume":"9","author":"F Ceriotti","year":"2015","unstructured":"Ceriotti F, et al. Comparative performance assessment of point-of-care testing devices for measuring glucose and ketones at the patient bedside. J Diabetes Sci Technol. 2015;9(2):268\u201377.","journal-title":"J Diabetes Sci Technol"},{"issue":"4","key":"2869_CR13","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1186\/s13054-014-0460-x","volume":"18","author":"HM Oudemans-van Straaten","year":"2014","unstructured":"Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC. Vitamin C revisited. Crit Care. 2014;18(4):460.","journal-title":"Crit Care"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02869-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-02869-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02869-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T17:03:15Z","timestamp":1621616595000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02869-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,21]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2869"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02869-4","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,21]]},"assertion":[{"value":"7 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The LOVIT trial has been approved by the Comit\u00e9 d\u2019\u00e9thique de la recherche du Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie - Centre hospitalier universitaire de Sherbrooke (Reference MP-31-2019-2945). The patient provided verbal and written consent for his participation in the LOVIT trial.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Drs. Adhikari and Lamontagne are co-principal investigators of the LOVIT trial.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"297"}}