{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:15:29Z","timestamp":1740147329326,"version":"3.37.3"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Uterus didelphys results from a failure in Mullerian duct fusion and may be associated with complete or partial vaginal septa. Most cases of uterus didelphys are discovered incidentally during the workup of infertility or recurrent miscarriage. The incidence of uterus didelphys has been reported to be 0.2% in the infertile population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 35-year-old white Arab woman, gravida 0, parity 0, with a history of primary infertility of 8\u00a0years (a well-known male factor) presented to our infertility center. She was diagnosed as having uterus didelphys with severe male factor. The patient had three previous failed <jats:italic>in vitro<\/jats:italic> fertilization\/intracytoplasmic sperm injection cycles outside our center.<\/jats:p>\n                <jats:p>This is a case report of an infertile woman with uterus didelphys who conceived twice following single embryo transfer in both uterine horns successively. After the first successful pregnancy in the left uterine horn, the initial decision was to transfer the embryo to the same horn (left) because of the previous successful transfer. The very deep and long vagina forced us to reach one of the cervices, in which the embryo was placed in the right uterine horn, followed by the second successful pregnancy in the other, smaller horn. The patient gave her informed consent, both verbal and written, to use her information and images for medical publication.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Pregnancy is possible in women with uterus didelphys using single embryo transfer in <jats:italic>in vitro<\/jats:italic> fertilization\/intracytoplasmic sperm injection cycles. It is recommended that both horns be given a chance.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02884-5","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T12:03:06Z","timestamp":1623672186000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Embryo transfer can be performed in either uterine horn. Two successive pregnancies in a patient with uterus didelphys: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-7019","authenticated-orcid":false,"given":"Zakwan","family":"Khrait","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"2884_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/humupd\/dmn018","volume":"14","author":"SH Saravelos","year":"2008","unstructured":"Saravelos SH, Cocksedge KA, Li TC. Prevalence and diagnosis congenital uterine anomalies in women with reproductive failure: a critical appraisal. Hum Reprod Update. 2008;14:415\u201329.","journal-title":"Hum Reprod Update"},{"key":"2884_CR2","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.jcma.2015.06.020","volume":"78","author":"MJ Yang","year":"2015","unstructured":"Yang MJ, Tseng JY, Chen CY, Li HY. Delivery of a double singleton pregnancies in a woman with a double uterus, double cervix, and complete septate vagina. J Chin Med Assoc. 2015;78:746\u20138.","journal-title":"J Chin Med Assoc"},{"key":"2884_CR3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0015-0282(16)60087-0","volume":"50","author":"L Fedele","year":"1988","unstructured":"Fedele L, Ferrazzi E, Dorta M, Vercellini P, Candiani G. Ultrasonography in the differential diagnosis of \u2018double\u2019 uteri. Fertil Steril. 1988;50:361\u20134.","journal-title":"Fertil Steril"},{"key":"2884_CR4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0301-2115(99)00259-6","volume":"91","author":"PK Heinonen","year":"2000","unstructured":"Heinonen PK. Clinical implications of the didelphic uterus: long term follow-up of 49 cases. Eur J Obstet Gynecol Reprod Biol. 2000;91:183\u201390.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"2884_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1093\/humupd\/7.2.161","volume":"7","author":"GF Grimbizis","year":"2001","unstructured":"Grimbizis GF, Camus M, Tarlatzis BC, Bontis JN, Devroey P. Clinical implications of uterine malformations and hysteroscopic treatment results. Hum Reprod Update. 2001;7(2):161\u201374.","journal-title":"Hum Reprod Update"},{"issue":"7","key":"2884_CR6","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.compmedimag.2004.05.008","volume":"28","author":"M Pui","year":"2004","unstructured":"Pui M. Imaging diagnosis of congenital uterine malformation. 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Best Pract Res Clin Obstet Gynaecol. 2004;18:557\u201376.","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"2884_CR11","doi-asserted-by":"publisher","first-page":"022996","DOI":"10.1101\/cshperspect.a022996","volume":"5","author":"E G\u00f3mez","year":"2015","unstructured":"G\u00f3mez E, Ru\u00edz-Alonso M, Miravet J, Sim\u00f3n C. Human endometrial transcriptomics: implications for embryonic implantation. Cold Spring Harb Perspect Med. 2015;5:022996.","journal-title":"Cold Spring Harb Perspect Med."},{"key":"2884_CR12","first-page":"008","volume":"06","author":"TK Al-Hussaini","year":"2016","unstructured":"Al-Hussaini TK. Two successful pregnancies using split embryo transfer in a woman with uterus didelphys: a case report. 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No animals were involved or harmed in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"317"}}