{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T12:29:13Z","timestamp":1743769753078},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Soonchunhyang University Research Fund"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Choroid plexus carcinoma is an intraventricular neoplasm originating from the choroid plexus epithelium and is of rare occurrence in adults. However, owing to the low prevalence of choroid plexus carcinoma, there is very limited information about the disease entity and treatment. Here we report a rare case of choroid plexus carcinoma in an adult patient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 46-year-old South Korean (East Asian) male presented with low back pain, headache, and diplopia. Magnetic resonance imaging demonstrated enhancing mass lesion in the left trigone, cerebellar with leptomeningeal spread. Surgery was performed via left parietal craniotomy, and the lesion was histologically confirmed to be choroid plexus carcinoma. The patient received adjuvant craniospinal irradiation for remnant mass and leptomeningeal spread. Magnetic resonance imaging performed immediately after completion of the treatment revealed a partial decrease in the size of the tumor. However, the patient expired died as a result of acute respiratory distress syndrome before follow-up of long-term outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Choroid plexus carcinoma with leptomeningeal spread in adults is very important for rapid diagnosis and treatment. In the case of the presence of leptomeningeal spread, craniospinal irradiation can be considered as a treatment method, but may have serious complications. Hence, the technique should be applied with care.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02887-2","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T23:05:37Z","timestamp":1621724737000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Choroid plexus carcinoma with leptomeningeal spread in an adult: a\u00a0case report and \u00a0review of the\u00a0literature"],"prefix":"10.1186","volume":"15","author":[{"given":"In Young","family":"Jo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Gu","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuk-Jin","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Sang","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,23]]},"reference":[{"key":"2887_CR1","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131:803\u201320.","journal-title":"Acta Neuropathol"},{"key":"2887_CR2","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.ijrobp.2017.08.012","volume":"99","author":"S Mallick","year":"2017","unstructured":"Mallick S, Benson R, Melgandi W, Rath GK. Effect of surgery, adjuvant therapy, and other prognostic factors on choroid plexus carcinoma: a systematic review and individual patient data analysis. Int J Radiat Oncol Biol Phys. 2017;99:1199\u2013206.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2887_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0303-8467(94)90029-9","volume":"96","author":"MK Baskaya","year":"1994","unstructured":"Baskaya MK, Erekul S, Egemen N, Gokalp HZ, Sertcelik A. Choroid plexus carcinoma of the lateral ventricle. Report of a case in an adult. Clin Neurol Neurosurg. 1994;96:47\u201351.","journal-title":"Clin Neurol Neurosurg"},{"key":"2887_CR4","first-page":"493","volume":"24","author":"A Fabi","year":"2005","unstructured":"Fabi A, Salesi N, Di Cocco B, Vidiri A, Visca P, Pace A, Carapella C, De Paula U, Mirri A, Cognetti F. Choroid plexus carcinoma in the adult: is there a role for chemotherapy? J Exp Clin Cancer Res. 2005;24:493\u20136.","journal-title":"J Exp Clin Cancer Res"},{"key":"2887_CR5","doi-asserted-by":"publisher","first-page":"E816","DOI":"10.1227\/01.NEU.0000348291.48810.C2","volume":"65","author":"AP Lozier","year":"2009","unstructured":"Lozier AP, Arbaje YM, Scheithauer BW. Supratentorial, extraventricular choroid plexus carcinoma in an adult: case report. Neurosurgery. 2009;65:E816-817.","journal-title":"Neurosurgery"},{"key":"2887_CR6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2176\/nmc.46.251","volume":"46","author":"H Osada","year":"2006","unstructured":"Osada H, Mori K, Yamamoto T, Nakao Y, Wada R, Maeda M. Choroid plexus carcinoma secreting carbohydrate antigen 19\u20139 in an adult case report. Neurol Med Chir (Tokyo). 2006;46:251\u20133.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"2887_CR7","first-page":"302","volume":"20","author":"S Ozdogan","year":"2015","unstructured":"Ozdogan S, Gergin YE, Gergin S, Senol O, Tiryaki M, Tatarli N, Hicdonmez T. Choroid plexus carcinoma in adults: an extremely rare case. Pan Afr Med J. 2015;20:302.","journal-title":"Pan Afr Med J"},{"issue":"Suppl 1","key":"2887_CR8","first-page":"e149","volume":"74","author":"TA Samuel","year":"2013","unstructured":"Samuel TA, Parikh J, Sharma S, Giller CA, Sterling K, Kapoor S, Pirkle C, Jillella A. Recurrent adult choroid plexus carcinoma treated with high-dose chemotherapy and syngeneic stem cell (bone marrow) transplant. J Neurol Surg A Cent Eur Neurosurg. 2013;74(Suppl 1):e149-154.","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"2887_CR9","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s11060-007-9428-x","volume":"85","author":"B Wrede","year":"2007","unstructured":"Wrede B, Liu P, Wolff JE. Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. J Neurooncol. 2007;85:345\u201351.","journal-title":"J Neurooncol"},{"key":"2887_CR10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ijrobp.2009.07.1701","volume":"78","author":"A Mazloom","year":"2010","unstructured":"Mazloom A, Wolff JE, Paulino AC. The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. 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J Neurooncol. 2011;103:155\u201362.","journal-title":"J Neurooncol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02887-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-02887-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02887-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T23:07:09Z","timestamp":1621724829000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02887-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,23]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2887"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02887-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,23]]},"assertion":[{"value":"20 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was approved by the Institutional Review Board of Soonchunhyang University Cheonan Hospital (approval no SCHCA 2018-05-051).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"286"}}