{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:56:32Z","timestamp":1782413792529,"version":"3.54.5"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Proteus\u00a0mirabilis<\/jats:italic> is the second most common pathogen that causes urinary tract infections after <jats:italic>Escherichia\u00a0coli<\/jats:italic>. In rare cases, it is associated with vertebral osteomyelitis. The underlying mechanism of this relationship may be related to the retrograde dissemination of bacteria through the paravertebral venous plexus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a case of an 80-year-old Taiwanese woman who had recurrent episodes of fever and chronic back pain for 1\u00a0year. All blood cultures were positive for <jats:italic>P.\u00a0mirabilis<\/jats:italic>. Inflammation scans and magnetic resonance imaging revealed a previously undetected vertebral lesion between the seventh and eighth thoracic vertebra. She responded well to treatment with antibiotics, reporting considerable relief of back pain and no fever recurrence at the 4-month follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Chronic back pain is a common but often dismissed symptom among the older population; osteomyelitis should be considered in patients with recurrent fever or neurological symptoms. Old age, chronic renal failure, and diabetes mellitus are possible predisposing factors for osteomyelitis. Our findings suggest that long-term treatment with antibiotics is effective for osteomyelitis caused by <jats:italic>P.\u00a0mirabilis,<\/jats:italic>, although surgery is required for abscess formation or serious vertebral destruction.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-02890-7","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:26:26Z","timestamp":1622161586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Proteus\u00a0mirabilis thoracic vertebral osteomyelitis: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-371X","authenticated-orcid":false,"given":"Ming-Hsiu","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hui","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Ching","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5828-5342","authenticated-orcid":false,"given":"Chi-Hung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"issue":"4","key":"2890_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jinf.2013.11.011","volume":"68","author":"M Kehrer","year":"2014","unstructured":"Kehrer M, Pedersen C, Jensen TG, Lassen AT. Increasing incidence of pyogenic spondylodiscitis: a 14-year population-based study. J Infect. 2014;68(4):313\u201320. https:\/\/doi.org\/10.1016\/j.jinf.2013.11.011.","journal-title":"J Infect."},{"issue":"2","key":"2890_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1756-185X.2009.01397.x","volume":"12","author":"TY Yong","year":"2009","unstructured":"Yong TY, Li JY. Proteus vertebral osteomyelitis. Int J Rheum Dis. 2009;12(2):155\u20137. https:\/\/doi.org\/10.1111\/j.1756-185X.2009.01397.x.","journal-title":"Int J Rheum Dis"},{"issue":"4","key":"2890_CR3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/00007632-198804000-00014","volume":"13","author":"RM Redfern","year":"1988","unstructured":"Redfern RM, Cottam SN, Phillipson AP. Proteus infection of the spine. Spine (Phila Pa 1976). 1988;13(4):439\u201341. https:\/\/doi.org\/10.1097\/00007632-198804000-00014.","journal-title":"Spine (Phila Pa 1976)."},{"issue":"1","key":"2890_CR4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/00000658-194007000-00016","volume":"112","author":"OV Batson","year":"1940","unstructured":"Batson OV. The function of the vertebral veins and their role in the spread of metastases. Ann Surg. 1940;112(1):138\u201349. https:\/\/doi.org\/10.1097\/00000658-194007000-00016.","journal-title":"Ann Surg."},{"issue":"11","key":"2890_CR5","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1056\/NEJMcp0910753","volume":"362","author":"W Zimmerli","year":"2010","unstructured":"Zimmerli W. Clinical practice vertebral osteomyelitis. N Engl J Med. 2010;362(11):1022\u20139. https:\/\/doi.org\/10.1056\/NEJMcp0910753.","journal-title":"N Engl J Med."},{"issue":"9","key":"2890_CR6","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s00402-013-1785-7","volume":"133","author":"A Hogan","year":"2013","unstructured":"Hogan A, Heppert VG, Suda AJ. Osteomyelitis. Arch Orthop Trauma Surg. 2013;133(9):1183\u201396. https:\/\/doi.org\/10.1007\/s00402-013-1785-7.","journal-title":"Arch Orthop Trauma Surg."},{"issue":"10","key":"2890_CR7","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1086\/340102","volume":"34","author":"MC McHenry","year":"2002","unstructured":"McHenry MC, Easley KA, Locker GA. Vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis. 2002;34(10):1342\u201350. https:\/\/doi.org\/10.1086\/340102.","journal-title":"Clin Infect Dis."},{"key":"2890_CR8","first-page":"189","volume":"16B","author":"S Selig","year":"1934","unstructured":"Selig S. Bacillus proteus osteomyelitis infection of the spine. J Bone Joint Surg. 1934;16B:189\u201392.","journal-title":"J Bone Joint Surg."},{"key":"2890_CR9","doi-asserted-by":"publisher","unstructured":"Fafalak M, Bryll-Perzan E, Bobde R, Bhattarai B. Proteus mirabilis: a rare but dangerous cause of osteomyelitis. p. A6560-A. https:\/\/doi.org\/10.1164\/ajrccm-conference.2019.199.1_MeetingAbstracts.A65602019.","DOI":"10.1164\/ajrccm-conference.2019.199.1_MeetingAbstracts.A65602019"},{"issue":"1","key":"2890_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1302\/0301-620x.61b1.370121","volume":"61","author":"JM Digby","year":"1979","unstructured":"Digby JM, Kersley JB. Pyogenic non-tuberculous spinal infection: an analysis of thirty cases. 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Scand J Infect Dis. 2006;38(6\u20137):575\u20136. https:\/\/doi.org\/10.1080\/00365540500504141.","journal-title":"Scand J Infect Dis."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02890-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-02890-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02890-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:38:56Z","timestamp":1622162336000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02890-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2890"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02890-7","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"assertion":[{"value":"26 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this case, no ethical approval was sought. Informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors confirmed that this work had no potential financial or nonfinancial conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"274"}}