{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T06:40:15Z","timestamp":1753684815367,"version":"3.37.3"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ovarian hyperstimulation syndrome is usually an iatrogenic and potentially life-threatening disease. It develops following ovulation induction and use of<jats:italic>in vitro<\/jats:italic>fertilization techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>A 32-year-old primigravida Ethiopian woman presented at 15\u00a0weeks gestation with a history of progressive bilateral leg swelling and abdominal pain of 2\u00a0weeks duration. She had triplet pregnancy and conceived through<jats:italic>in vitro<\/jats:italic>fertilization. She was managed in intensive care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with multiple pregnancy following<jats:italic>in vitro<\/jats:italic>fertilization conception can have ovarian hyperstimulation syndrome as late as 15\u00a0weeks gestation. Hence, frequent follow-up should be continued to detect early signs of OHSS to avoid further complications and need of intensive care unit care.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13256-021-02936-w","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T23:06:48Z","timestamp":1625612808000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare presentation of endogenous human chorionic gonadotrophin associated severe ovarian hyperstimulation in the\u00a0second trimester: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-0804","authenticated-orcid":false,"given":"Abraham","family":"Fessehaye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wondimu","family":"Gudu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"2936_CR1","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/s0015-0282(98)00484-1","volume":"71","author":"A Pellicer","year":"1999","unstructured":"Pellicer A, Albert C, Mercader A, Bonilla-Musoles F, Remoh\u00ed J, Sim\u00f3n C. The pathogenesis of ovarian hyperstimulation syndrome: in vivo studies investigating the role of interleukin-1beta, interleukin-6, and vascular endothelial growth factor. Fertil Steril. 1999;71:482\u20139. https:\/\/doi.org\/10.1016\/s0015-0282(98)00484-1.","journal-title":"Fertil Steril"},{"issue":"24","key":"2936_CR2","doi-asserted-by":"publisher","first-page":"4384","DOI":"10.12998\/wjcc.v7.i24.4384","volume":"7","author":"J Gui","year":"2019","unstructured":"Gui J, Zhang J, Xu WM, Ming L. Spontaneous ovarian hyperstimulation syndrome: report of two cases. World J Clin Cases. 2019;7(24):4384\u201390.","journal-title":"World J Clin Cases"},{"key":"2936_CR3","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1093\/humrep\/12.6.1129","volume":"12","author":"U Elchalal","year":"1997","unstructured":"Elchalal U, Schenker JG. The pathophysiology of ovarian hyperstimulation syndrome\u2014views and ideas. 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Human Reprod. 2005;20(4):910\u20134.","DOI":"10.1093\/humrep\/deh713"},{"key":"2936_CR12","unstructured":"Verdin H. Ovarian hyperstimulation syndrome. Human Fertilisation and Embryology Authority (2018)."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02936-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-02936-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-02936-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T02:25:33Z","timestamp":1672712733000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-02936-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2936"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-02936-w","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2021,7,7]]},"assertion":[{"value":"13 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from patient\u2019s family members for publication of this case report and any accompanying images. 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