{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T05:27:31Z","timestamp":1767245251495,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Anemia is a serious global health problem that affects individuals of all ages but particularly women of reproductive age. Iron deficiency anemia is one of the most common causes of anemia seen in women, with menstruation being one of the leading causes. Excessive, prolonged, and irregular uterine bleeding, also known as menometrorrhagia, can lead to severe anemia. In this case report, we present a case of a premenopausal woman with menometrorrhagia leading to severe iron deficiency anemia with record low hemoglobin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 42-year-old Hispanic woman with no known past medical history presented with a chief complaint of increasing fatigue and dizziness for 2\u00a0weeks. Initial vitals revealed temperature of 36.1\u00a0\u00b0C, blood pressure 107\/47\u00a0mmHg, heart rate 87\u00a0beats\/minute, respiratory rate 17\u00a0breaths\/minute, and oxygen saturation 100% on room air. She was fully alert and oriented without any neurological deficits. Physical examination was otherwise notable for findings typical of anemia, including: marked pallor with pale mucous membranes and conjunctiva, a systolic flow murmur, and koilonychia of her fingernails. Her initial laboratory results showed a critically low hemoglobin of 1.4\u00a0g\/dL and severe iron deficiency. After further diagnostic workup, her profound anemia was likely attributed to a long history of menometrorrhagia, and her remarkably stable presentation was due to impressive, years-long compensation. Over the course of her hospital stay, she received blood transfusions and intravenous iron repletion. Her symptoms of fatigue and dizziness resolved by the end of her hospital course, and she returned to her baseline ambulatory and activity level upon discharge.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Critically low hemoglobin levels are typically associated with significant symptoms, physical examination findings, and hemodynamic instability. To our knowledge, this is the lowest recorded hemoglobin in a hemodynamically stable patient not requiring cardiac or supplemental oxygen support.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03024-9","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T13:04:10Z","timestamp":1631538250000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Critical iron deficiency anemia with record low hemoglobin: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-0468","authenticated-orcid":false,"given":"Audrey L.","family":"Chai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen Y.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rastko","family":"Rako\u010devi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"issue":"2","key":"3024_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.hoc.2015.11.002","volume":"30","author":"NJ Kassebaum","year":"2016","unstructured":"Kassebaum NJ. The global burden of anemia. Hematol Oncol Clin. 2016;30(2):247\u2013308.","journal-title":"Hematol Oncol Clin"},{"issue":"sup1","key":"3024_CR2","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.3109\/09513590.2012.637341","volume":"27","author":"J Donnez","year":"2011","unstructured":"Donnez J. Menometrorrhagia during the premenopause: an overview. Gynecol Endocrinol. 2011;27(sup1):1114\u20139.","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"3024_CR3","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1182\/blood.V68.3.726.726","volume":"68","author":"JD Cook","year":"1986","unstructured":"Cook JD, Skikne BS, Lynch SR, Reusser ME. Estimates of iron sufficiency in the US population. Blood. 1986;68(3):726\u201331.","journal-title":"Blood"},{"issue":"sup1","key":"3024_CR4","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.3109\/09513590.2012.636916","volume":"27","author":"S Palacios","year":"2011","unstructured":"Palacios S. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"472"}}