{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:08:54Z","timestamp":1774066134109,"version":"3.50.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Troponin levels can be elevated in various diseases other than acute myocardial infarction, including sepsis. In diseases without myocardial necrosis, the elevated troponin levels are relatively low and normalize quickly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 61-year-old Japanese man with impaired consciousness was transported to our hospital. He was diagnosed as having pneumonia and septic shock. His condition was severe, but his clinical course was good. However, his troponin level remained extremely high during admission; on the second day, it was higher than the measurable range. We consulted a cardiologist and performed echocardiography and myocardial perfusion scintigraphy but found no new ischemic changes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In septic shock, troponin levels can be extremely high, which can persist even after recovery, as in very large myocardial infarctions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03027-6","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T23:06:11Z","timestamp":1631315171000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Extremely high troponin levels induced by septic shock: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Naoki","family":"Matsunaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Fukuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"3027_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.5935\/0103-507X.20190001","volume":"31","author":"HA Vaz","year":"2019","unstructured":"Vaz HA, Guimaraes RB, Dutra C. Challenges in high-sensitive troponin assay interpretation for intensive therapy. Rev Bras Ter Intensiva. 2019;31:93\u2013105.","journal-title":"Rev Bras Ter Intensiva"},{"issue":"4","key":"3027_CR2","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1097\/CCM.0000000000000107","volume":"42","author":"G Landesberg","year":"2014","unstructured":"Landesberg G, Jaffe AS, Gilon D, et\u00a0al. Troponin elevation in severe sepsis and septic shock: the role of left ventricular diastolic dysfunction and right ventricular dilatation*. Crit Care Med. 2014;42(4):790\u2013800.","journal-title":"Crit Care Med"},{"issue":"2","key":"3027_CR3","doi-asserted-by":"publisher","first-page":"e004040","DOI":"10.1161\/CIRCOUTCOMES.117.004040","volume":"11","author":"JF Frencken","year":"2018","unstructured":"Frencken JF, Donker DW, Spitoni C, et\u00a0al. Myocardial injury in patients with sepsis and its association with long-term outcome. Circ Cardiovasc Qual Outcomes. 2018;11(2):e004040.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"5","key":"3027_CR4","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1513\/AnnalsATS.201804-286OC","volume":"16","author":"JF Frencken","year":"2019","unstructured":"Frencken JF, van Baal L, Kappen TH, et\u00a0al. Myocardial injury in critically ill patients with community-acquired pneumonia. A cohort study. Ann Am Thorac Soc. 2019;16(5):606\u201312.","journal-title":"Ann Am Thorac Soc"},{"issue":"5","key":"3027_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11886-020-01277-2","volume":"22","author":"M L'Heureux","year":"2020","unstructured":"L\u2019Heureux M, Sternberg M, Brath L, Turlington J, Kashiouris MG. Sepsis-induced cardiomyopathy: a comprehensive review. Curr Cardiol Rep. 2020;22(5):35.","journal-title":"Curr Cardiol Rep"},{"issue":"2","key":"3027_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/jcm8020239","volume":"8","author":"JS Kim","year":"2019","unstructured":"Kim JS, Kim M, Kim YJ, et\u00a0al. Troponin testing for assessing sepsis-induced myocardial dysfunction in patients with septic shock. J Clin Med. 2019;8(2):239.","journal-title":"J Clin Med"},{"key":"3027_CR7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/2110-5820-1-6","volume":"1","author":"A Vieillard-Baron","year":"2011","unstructured":"Vieillard-Baron A. Septic cardiomyopathy. Ann Intensive Care. 2011;1:6.","journal-title":"Ann Intensive Care"},{"key":"3027_CR8","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.jacc.2016.06.049","volume":"68","author":"AK Lee","year":"2016","unstructured":"Lee AK, McEvoy JW, Hoogeveen RC, Ballantyne CM, Selvin E. Severe hypoglycemia and elevated high-sensitivity cardiac troponin T in older adults with diabetes: the ARIC Study. J Am Coll Cardiol. 2016;68:1370\u20131.","journal-title":"J Am Coll Cardiol"},{"key":"3027_CR9","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1097\/CCM.0b013e318192faa3","volume":"37","author":"VC Vasile","year":"2009","unstructured":"Vasile VC, Babuin L, Rio Perez JA, et\u00a0al. Long-term prognostic significance of elevated cardiac troponin levels in critically ill patients with acute gastrointestinal bleeding. Crit Care Med. 2009;37:140\u20137.","journal-title":"Crit Care Med"},{"issue":"3","key":"3027_CR10","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ajem.2010.12.022","volume":"30","author":"SH Oh","year":"2012","unstructured":"Oh SH, Kim YM, Kim HJ, et\u00a0al. Implication of cardiac marker elevation in patients who resuscitated from out-of-hospital cardiac arrest. Am J Emerg Med. 2012;30(3):464\u201371.","journal-title":"Am J Emerg Med"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03027-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-03027-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03027-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:21:49Z","timestamp":1631319709000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-03027-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,11]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3027"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-03027-6","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,11]]},"assertion":[{"value":"3 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"466"}}