{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:27:40Z","timestamp":1768638460019,"version":"3.49.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p><jats:italic>Haemophilus\u00a0influenzae<\/jats:italic> is a Gram-negative coccobacillus that can cause many different kinds of infection, ranging from mild ear infection to life-threatening diseases like epiglottitis and meningitis. Encapsulated type b <jats:italic>Haemophilus\u00a0influenzae<\/jats:italic> was most commonly responsible for <jats:italic>Haemophilus\u00a0influenzae<\/jats:italic> meningitis in children before introduction of <jats:italic>Haemophilus\u00a0influenzae<\/jats:italic> conjugate vaccine. None or partially immunized children are acquiring meningitis owing to resistant strains of <jats:italic>Haemophilus\u00a0influenzae<\/jats:italic>, namely beta-lactamase-negative ampicillin-resistant strain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We reported the case of a 2-year-old Emirati boy who presented to our emergency department with fever, diarrhea, vomiting, and fluctuating levels of consciousness. He was developmentally normal with no significant past medical history, except he was partially immunized. Earlier, he had been treated for acute gastroenteritis with intravenous fluids and antiemetics in another hospital and was discharged. His parents escorted him to our emergency department as he became very drowsy. Examination revealed that he was in septic shock. He was immediately treated with oxygen, intravenous antibiotics, and fluids after performing septic workup. He was then shifted to intensive care unit. Blood culture and cerebrospinal fluid Gram stain confirmed diagnosis of beta-lactamase-negative ampicillin-resistant <jats:italic>Haemophilus\u00a0influenzae<\/jats:italic>. He was started on intravenous ceftriaxone, acyclovir, and dexamethasone. He still spiked fever after 1\u00a0week. Therefore, ceftriaxone was replaced by meropenem. He recovered well with no sequelae.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This case highlights atypical presentation of life-threatening illness along with microbial resistance that had positive outcome due to timely diagnosis and aggressive management by a multidisciplinary team.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03041-8","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:03:12Z","timestamp":1629244992000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b meningitis in partially immunized immunocompetent child: a\u00a0case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Majid Ali","family":"Qureshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Asad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeel","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid","family":"Abuhammour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"3041_CR1","unstructured":"Immunisation guidelines Dubai Health Authority, Department of Public Health and Safety, Health Policy and Strategy Sector. https:\/\/www.dha.gov.ae\/Documents\/HRD\/Immunization%20Guidelines.pdf."},{"key":"3041_CR2","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ijid.2006.05.009","volume":"11","author":"N Dash","year":"2007","unstructured":"Dash N, Ameen AMS, Sheek Hussein MM, Smego RA Jr. Epidemiology of meningitis at Al-Ain, United Arab Emirates, 2000\u20132005. Int J Infect Dis. 2007;11:309\u201312.","journal-title":"Int J Infect Dis"},{"issue":"6","key":"3041_CR3","first-page":"861","volume":"55","author":"T Otuska","year":"2002","unstructured":"Otuska T, Okugawa T, Kaneko U. Meropenem was effective to the bacterial meningitis due to beta-lactamase negative ampicillin-resistant Haemophilus influenzae; case report. Jpn J Antibiot. 2002;55(6):861\u20135.","journal-title":"Jpn J Antibiot"},{"issue":"Suppl","key":"3041_CR4","doi-asserted-by":"publisher","first-page":"S180","DOI":"10.1093\/infdis\/137.Supplement.S180","volume":"137","author":"EA Steinberg","year":"1978","unstructured":"Steinberg EA, Overturf GD, Wilkins J, Baraff LJ, Streng. Failure of cefamandole in treatment of meningitis due to Haemophilus influenzae type b; case report. J Infect Dis. 1978;137(Suppl):S180\u20139.","journal-title":"J Infect Dis"},{"issue":"5","key":"3041_CR5","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1093\/infdis\/162.5.1118","volume":"162","author":"PM Mendelman","year":"1990","unstructured":"Mendelman PM, Chaffin DO, Krilov LR, Kalaitzoglou G, Serfass DA, Onay O, Wiley EA, Overturf GD, Rubin LG. Cefuroxime treatment failure of nontypeable Haemophilus influenzae meningitis associated with alteration of penicillin-binding proteins, case report. J Infect Dis. 1990;162(5):1118\u201323.","journal-title":"J Infect Dis"},{"issue":"3","key":"3041_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.11150\/kansenshogakuzasshi.88.291","volume":"88","author":"K Abe","year":"2014","unstructured":"Abe K, Hoshino T, Imuta N, Nishi J, Ishiwada N. Bacterial meningitis caused by beta-lactamase-negative, ampicillin-resistant nontypeable Haemophilus influenzae in a 1-year-old girl: case report. Kansenshogaku Zasshi. 2014;88(3):291\u20136.","journal-title":"Kansenshogaku Zasshi"},{"issue":"7","key":"3041_CR7","doi-asserted-by":"publisher","first-page":"604","DOI":"10.11150\/kansenshogakuzasshi1970.78.604","volume":"78","author":"F Sudo","year":"2004","unstructured":"Sudo F, Nakamura A, Hoshino T, Ishiwada N, Kohno Y. Successful treatment of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b meningitis with high dose ceftriaxone administration. Kansenshogaku Zasshi. 2004;78(7):604\u20138.","journal-title":"Kansenshogaku Zasshi"},{"key":"3041_CR8","unstructured":"National Institute for Health and Care Excellence (NICE) guidance for meningitis (bacterial) and meningococcal septicaemia in under 16s: recognition, diagnosis and management. Clinical guideline (CG102), Publish date: June 2010, Last updated: February 2015. https:\/\/www.nice.org.uk\/guidance\/cg102\/chapter\/1-Guidance."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03041-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-03041-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03041-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:03:30Z","timestamp":1629245010000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-03041-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3041"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-03041-8","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]},"assertion":[{"value":"18 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian(s) for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"433"}}