{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:28:46Z","timestamp":1762928926212},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Severe acute respiratory syndrome coronavirus 2, the cause of coronavirus disease 2019, has become a global pandemic. Currently, there is no definitive treatment for coronavirus disease 2019. Convalescent plasma therapy has become a potential specific curative method, while vaccines as protection modalities require further work.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Eight non-intubated Indonesian patients, ages ranging from 40 to 74\u00a0years old, with coronavirus disease 2019 confirmed by viral Ribonucleid Acid (RNA) real-time polymerase chain reaction tests were included. Four patients were administered two doses of 200\u00a0mL convalescent plasma, and the other four patients were administered one dose of convalescent plasma with an antibody titer of 1:320, within the first 14\u00a0days since symptoms occurred. The median times from illness onset to convalescent plasma therapy and from the first day of hospital admission to convalescent plasma therapy were 13 and 6.5\u00a0days, respectively. All patients showed improvements in clinical symptoms, laboratory parameters, thorax imaging, negative conversion of polymerase chain reaction results, and decreased oxygen supplementation within 1\u00a0week after convalescent plasma therapy. Patients with two convalescent plasma doses tended to have faster recovery than those with one convalescent plasma dose. No severe adverse effects were observed in any patient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This is the first case series in Indonesia showing that convalescent plasma therapy is safe and well tolerated and that early convalescent plasma therapy before the patient is intubated could potentially prevent disease progression, increase the recovery rate, and shorten the inpatient time of stay.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03059-y","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T09:03:03Z","timestamp":1637658183000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series"],"prefix":"10.1186","volume":"15","author":[{"given":"Theresia Monica","family":"Rahardjo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Yogipranata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardian Hediyanto","family":"Naswan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fitri Rahayu","family":"Sari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fajar","family":"Budiono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hernawati","family":"Permatasari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H. R. Driantik","family":"Chuntari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"3059_CR1","unstructured":"Indonesia: WHO Coronavirus Disease (COVID-19) Dashboard. WHO coronavirus disease (COVID-19) dashboard. https:\/\/covid19.who.int. Accessed 1 June 2021."},{"issue":"4","key":"3059_CR2","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1172\/JCI138003","volume":"130","author":"A Casadevall","year":"2020","unstructured":"Casadevall A, Pirofski LA. The convalescent sera option for containing COVID-19. J Clin Invest. 2020;130(4):1545\u20138. https:\/\/doi.org\/10.1172\/JCI138003.","journal-title":"J Clin Invest"},{"key":"3059_CR3","doi-asserted-by":"publisher","DOI":"10.14744\/etd.2020.36528","author":"O Ozdemir","year":"2020","unstructured":"Ozdemir O, Arsoy HEM. Convalescent (immune) plasma therapy with all aspects: yesterday, today and COVID-19. Erciyes Med J. 2020. https:\/\/doi.org\/10.14744\/etd.2020.36528.","journal-title":"Erciyes Med J"},{"issue":"4","key":"3059_CR4","first-page":"1","volume":"33","author":"D Focosi","year":"2020","unstructured":"Focosi D, Anderson AO, Tang JW, Tuccori M. Convalescent plasma therapy for COVID-19: state of the art. Clin Microbiol. 2020;33(4):1\u201317.","journal-title":"Clin Microbiol"},{"key":"3059_CR5","volume-title":"Guidelines of convalescent plasma therapy for COVID-19","author":"TM Rahardjo","year":"2021","unstructured":"Rahardjo TM, Triyono T, Harly PR. Guidelines of convalescent plasma therapy for COVID-19. 3rd ed. Jakarta: MMP; 2021.","edition":"3"},{"issue":"6","key":"3059_CR6","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1172\/JCI138745","volume":"130","author":"EM Bloch","year":"2020","unstructured":"Bloch EM, et\u00a0al. Deployment of convalescent plasma for the prevention and treatment of COVID-19. Clin Investig. 2020;130(6):2757\u201365. https:\/\/doi.org\/10.1172\/JCI138745.","journal-title":"Clin Investig"},{"issue":"17","key":"3059_CR7","doi-asserted-by":"publisher","first-page":"9490","DOI":"10.1073\/pnas.2004168117","volume":"117","author":"K Duan","year":"2020","unstructured":"Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, et\u00a0al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci. 2020;117(17):9490\u20136.","journal-title":"Proc Natl Acad Sci"},{"issue":"16","key":"3059_CR8","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1001\/jama.2020.4783","volume":"323","author":"C Shen","year":"2020","unstructured":"Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et\u00a0al. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA. 2020;323(16):1582\u20139. https:\/\/doi.org\/10.1001\/jama.2020.4783.","journal-title":"JAMA"},{"key":"3059_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.transci.2020.102875","volume":"59","author":"H Abolghasemi","year":"2020","unstructured":"Abolghasemi H, Eshghi P, Cheraghali AM, Fooladi AAI, Moghaddam FB, Imanizadeh S, et\u00a0al. Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: results of a multicenter clinical study. Transfus Apheres Sci. 2020;59:1\u20135. https:\/\/doi.org\/10.1016\/j.transci.2020.102875.","journal-title":"Transfus Apheres Sci"},{"key":"3059_CR10","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1038\/s41591-020-1088-9","volume":"26","author":"STH Liu","year":"2020","unstructured":"Liu STH, Lin HM, Baine I, Wajnberg A, Gumprecht JP, Rahman F, et\u00a0al. Convalescent plasma treatment for severe COVID-19: a propensity score-matched control study. 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Rev Med Virol. 2021. https:\/\/doi.org\/10.1002\/rmv.2225.","journal-title":"Rev Med Virol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03059-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-03059-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03059-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T21:03:46Z","timestamp":1637701426000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-03059-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3059"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-03059-y","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"15 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethic approval was given by ethic committee of Primaya Hospital Tangerang as the place at which all patients were treated and received CPT.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patients for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We declare that this study has no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"564"}}