{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T02:53:58Z","timestamp":1707101638506},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hodgkin lymphoma is a systemic disease that commonly involves the cervical, supraclavicular, and mediastinal lymph nodes. The involvement of central nervous system in Hodgkin lymphoma is extremely rare, and diagnosis is usually established using distinct morphological and immunohistochemical staining on the tissue biopsied. Extranodal presentation of HL is a rare occurrence. It has been evident that prognosis is encouraging in patients with disease that is limited to just central nervous system initially or as relapse, compared with involvement of multiple sites of relapse.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We herein report a case of a 35-year-old South-East Asian male with relapsed\u00a0Hodgkin lymphoma. The patient developed a parotid gland lesion, cervical lymphadenopathy with significant weight loss, and intermittent night sweats. Along with spread to the central nervous system, there was a high suspicion of tuberculosis. Upon biopsy of his cervical lymph node, the patient was confirmed to have Hodgkin lymphoma. Immediate treatment began with six cycles of chemotherapy consisting of adriamycin, bleomycin, vinblastine, and dacarbazine. The patient received three cycles of chemotherapy consisting of ifosfamide, carboplatin, and etoposide but then was lost to follow-up. Five years later, the patient suffered a road traffic accident. Upon work-up, a right parietal space-occupying lesion with moderate cerebral edema and midline shift was found on computed tomography of the brain. The patient underwent resection of the space-occupying lesion of brain, with features consistent with classical Hodgkin lymphoma on histopathology examination. It is crucial for such lesions to be investigated meticulously to rule out any secondary disease process.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Relapsed Hodgkin lymphoma with central nervous system involvement is relatively rare with just over two dozen cases reported to date and is observed infrequently in developing nations. Therefore, space-occupying lesion should always be investigated, and biopsy of such lesions is gold standard to establish diagnosis. With timely appropriate therapy, complete remission can be achieved. However, large-scale studies would be prudent to explore the presentation, survival, and treatment options for patients with Hodgkin lymphoma involving the central nervous system.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03118-4","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:03:51Z","timestamp":1635462231000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Atypical involvement of central nervous system in classic Hodgkin lymphoma: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Shanila","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babar","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Raza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam","family":"Haider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"issue":"5","key":"3118_CR1","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1182\/blood-2008-04-151563","volume":"112","author":"ER Gerstner","year":"2008","unstructured":"Gerstner ER, Abrey LE, Schiff D, Ferreri AJ, Lister A, Montoto S, Tsang R, Thiel E, Graus F, Behringer D, Illerhaus G. CNS Hodgkin lymphoma. Blood. 2008;112(5):1658\u201361.","journal-title":"Blood"},{"issue":"2","key":"3118_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s11060-010-0320-8","volume":"102","author":"S Torgerson","year":"2011","unstructured":"Torgerson S, Olteanu H, Tinguely M, Fenske TS. Central nervous system Hodgkin lymphoma: case report and review of the literature. J Neurooncol. 2011;102(2):329\u201334.","journal-title":"J Neurooncol"},{"key":"3118_CR3","first-page":"196","volume":"8","author":"KZ Cecyn","year":"2017","unstructured":"Cecyn KZ, Chaves EM, Oliveira JS. Primary central nervous system involvement in classical Hodgkin\u2019s lymphoma: case report and review of the literature. J Blood Lymph. 2017;8:196.","journal-title":"J Blood Lymph"},{"issue":"3","key":"3118_CR4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/ccr3.66","volume":"2","author":"SA van Blydenstein","year":"2014","unstructured":"van Blydenstein SA, PatherMoosaPatel VP, Lakha AS, Westgarth-Taylor T, Thompson E, Kolloori A. Classical Hodgkin lymphoma involving the central nervous system (brain)\u2014an unusual presentation. Clin Case Rep. 2014;2(3):88.","journal-title":"Clin Case Rep"},{"issue":"1","key":"3118_CR5","doi-asserted-by":"publisher","first-page":"28","DOI":"10.4103\/ajm.AJM_104_18","volume":"9","author":"A Alfaseh","year":"2019","unstructured":"Alfaseh A, Rajeh MN, Hamed G. Primary central nervous system Hodgkin lymphoma: a case discussion and a hypothesis on the etiology. Avicenna J Med. 2019;9(1):28\u201331. https:\/\/doi.org\/10.4103\/ajm.AJM_104_18.","journal-title":"Avicenna J Med."},{"key":"3118_CR6","first-page":"2011","volume":"1","author":"S Grimm","year":"2011","unstructured":"Grimm S, Chamberlain M. Hodgkin\u2019s lymphoma: a review of neurologic complications. Adv Hematol. 2011;1:2011.","journal-title":"Adv Hematol"},{"issue":"7","key":"3118_CR7","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1093\/annonc\/mdl477","volume":"18","author":"D Lorusso","year":"2007","unstructured":"Lorusso D, Di Stefano A, Carone V, Fagotti A, Pisconti S, Scambia G. Pegylated liposomal doxorubicin-related palmar-plantar erythrodysesthesia (\u2018hand-foot\u2019 syndrome). 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Acta Neurochir. 2013;155(1):19\u201324.","journal-title":"Acta Neurochir"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03118-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-03118-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03118-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:04:24Z","timestamp":1635462264000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-03118-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,29]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3118"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-03118-4","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,29]]},"assertion":[{"value":"7 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We have written consent from the Department of Oncology, Jinnah Postgraduate Medical Center to use this patient\u2019s information.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s next of kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"532"}}