{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:39:10Z","timestamp":1778513950808,"version":"3.51.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>This report describes the case of a patient whose pituitary microadenoma resolved after he contracted coronavirus disease 2019. To our knowledge, this is one of the first reported cases of pituitary tumor resolution due to viral illness. We present this case to further investigate the relationship between inflammatory response and tumor remission.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 32-year-old man in Yemen presented to the hospital with fever, low blood oxygen saturation, and shortness of breath. The patient was diagnosed with coronavirus disease 2019. Past medical history included pituitary microadenoma that was diagnosed using magnetic resonance imaging and secondary adrenal insufficiency, which was treated with steroids. Due to the severity of coronavirus disease 2019, he was treated with steroids and supportive care. Three\u00a0months after his initial presentation to the hospital, brain magnetic resonance imaging was performed and compared with past scans. Magnetic resonance imaging revealed changes in the microadenoma, including the disappearance of the hypointense lesion and hyperintense enhancement observed on the previous scan.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Pituitary adenomas rarely undergo spontaneous resolution. Therefore, we hypothesized that tumor resolution was secondary to an immune response to coronavirus disease 2019.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03127-3","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T14:02:41Z","timestamp":1635775361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Resolution of pituitary microadenoma after coronavirus disease 2019: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Salah","family":"Raishan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Alsabri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Mary","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Brett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"issue":"2","key":"3127_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1530\/eje.1.02326","volume":"156","author":"W Saeger","year":"2007","unstructured":"Saeger W, L\u00fcdecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S. Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol. 2007;156(2):203\u201316.","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"3127_CR2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.ecl.2007.10.011","volume":"37","author":"ME Molitch","year":"2008","unstructured":"Molitch ME. Nonfunctioning pituitary tumors and pituitary incidentalomas. Endocrinol Metab Clin North Am. 2008;37(1):151\u201371.","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"4","key":"3127_CR3","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1055\/s-2002-36708","volume":"20","author":"SS Chaidarun","year":"2002","unstructured":"Chaidarun SS, Klibanski A. Gonadotropinomas. Semin Reprod Med. 2002;20(4):339\u201348.","journal-title":"Semin Reprod Med."},{"issue":"5","key":"3127_CR4","doi-asserted-by":"publisher","first-page":"R179","DOI":"10.1530\/EJE-14-0794","volume":"172","author":"C Capatina","year":"2015","unstructured":"Capatina C, Inder W, Karavitaki N, Wass JA. Management of endocrine disease: pituitary tumour apoplexy. Eur J Endocrinol. 2015;172(5):R179\u201390. https:\/\/doi.org\/10.1530\/EJE-14-0794.","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"3127_CR5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9174","volume":"12","author":"A Jaafar","year":"2020","unstructured":"Jaafar A, Mohd Shokri S, Paramasvaran S, et\u00a0al. Now you see, now you don\u2019t: a case of spontaneous regression of pituitary tumour. Cureus. 2020;12(7): e9174. https:\/\/doi.org\/10.7759\/cureus.9174.","journal-title":"Cureus"},{"key":"3127_CR6","unstructured":"Remission of Hodgkin Lymphoma after COVID-19 February\u00a016,\u00a02021 Editor\u2019s note: find the latest COVID-19 news and guidance in Medscape\u2019s Coronavirus Resource Center. Sarah Challenor, MD, and David Tucker, MD."},{"issue":"2","key":"3127_CR7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3109\/0284186X.2012.711954","volume":"52","author":"AH K\u00f8stner","year":"2013","unstructured":"K\u00f8stner AH, Johansen RF, Schmidt H, M\u00f8lle I. Regression in cancer following fever and acute infection. Acta Oncol. 2013;52(2):455\u20137. https:\/\/doi.org\/10.3109\/0284186X.2012.711954 (Epub 2012 Aug 30 PMID: 22934556).","journal-title":"Acta Oncol"},{"issue":"1","key":"3127_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2478\/jtim-2020-0003","volume":"8","author":"M Liu","year":"2020","unstructured":"Liu M, Wang T, Zhou Y, Zhao Y, Zhang Y, Li J. Potential role of ACE2 in coronavirus disease 2019 (COVID-19) prevention and management. J Transl Int Med. 2020;8(1):9\u201319. https:\/\/doi.org\/10.2478\/jtim-2020-0003.","journal-title":"J Transl Int Med."},{"key":"3127_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108427","volume":"215","author":"K Yuki","year":"2020","unstructured":"Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: a review. Clin Immunol. 2020;215: 108427. https:\/\/doi.org\/10.1016\/j.clim.2020.108427.","journal-title":"Clin Immunol"},{"key":"3127_CR10","doi-asserted-by":"publisher","first-page":"10988","DOI":"10.1016\/j.mehy.2020.109884","volume":"143","author":"JJL Jacobs","year":"2020","unstructured":"Jacobs JJL. Neutralizing antibodies mediate virus-immune pathology of COVID-19. Med Hypotheses. 2020;143:10988.","journal-title":"Med Hypotheses"},{"issue":"7","key":"3127_CR11","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1084\/jem.20021052","volume":"196","author":"E Rom\u00e1n","year":"2002","unstructured":"Rom\u00e1n E, Miller E, Harmsen A, Wiley J, Von Andrian UH, Huston G, Swain SL. CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. 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The researchers obtained approval from Al-Thawra Modern General Hospital IRB committee. Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"544"}}