{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:20:17Z","timestamp":1791231617006,"version":"4.1.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carney\u2019s triad is a rare syndrome comprising gastrointestinal stromal tumor, extra-adrenal paraganglioma, and pulmonary chondroma along with newer additions of adrenal adenoma and esophageal leiomyoma. The triad is completely manifest in only 25\u201330% cases, with most patients presenting with two out of three parts of the syndrome. Wild-type succinate-dehydrogenase-deficient gastric gastrointestinal stromal tumor forms the most common component of Carney\u2019s triad and is usually multicentric and multifocal. It usually demonstrates indolent behavior and resistance to imatinib; hence, the management remains predominantly surgical. Pulmonary chondromas are commonly unilateral and multiple with slow-growing nature, which allows for conservative management. Adrenocortical adenomas are found in 20% of patients and are usually detected as incidentalomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 49-year-old Asian male presented with upper gastrointestinal bleed and was diagnosed with multiple gastric succinate-dehydrogenase-deficient gastrointestinal stromal tumors. On evaluation, he was found to have left pulmonary chondroma and non-secretory adrenal adenoma, thus completing the Carney\u2019s triad. He underwent surgery with sleeve gastrectomy and excision of the antral tumor nodule, while the adrenal and pulmonary tumors have been under close follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Literature regarding Carney\u2019s triad is scarce, especially from the Indian setting. Our report aims to highlight the various manifestations of this syndrome with emphasis on management of wild-type succinate-dehydrogenase-deficient gastrointestinal stromal tumor. Radical gastric surgeries do not offer a survival advantage in this condition; hence, more conservative modalities of resection can be adopted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-021-03149-x","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T19:02:52Z","timestamp":1637002972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Carney\u2019s triad in an adult male from a tertiary care center in India: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Ghazal","family":"Tansir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar Ranjan","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Galodha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasenjit","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamim Ahmed","family":"Shamim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-3083","authenticated-orcid":false,"given":"Sameer","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"issue":"26","key":"3149_CR1","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1056\/NEJM197706302962609","volume":"296","author":"JA Carney","year":"1977","unstructured":"Carney JA, Sheps SG, Go VL, Gordon H. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. N Engl J Med. 1977;296(26):1517\u20138.","journal-title":"N Engl J Med"},{"issue":"10","key":"3149_CR2","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.1210\/jc.2009-1156","volume":"94","author":"JA Carney","year":"2009","unstructured":"Carney JA. Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. J Clin Endocrinol Metab. 2009;94(10):3656\u201362.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"3149_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/PAS.0b013e3181c20f4f","volume":"34","author":"L Zhang","year":"2010","unstructured":"Zhang L, Smyrk TC, Young WF, Stratakis CA, Carney JA. Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. Am J Surg Pathol. 2010;34(1):53\u201364.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"3149_CR4","doi-asserted-by":"publisher","first-page":"543","DOI":"10.4065\/74.6.543","volume":"74","author":"JA Carney","year":"1999","unstructured":"Carney JA. Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney triad): natural history, adrenocortical component, and possible familial occurrence. Mayo Clin Proc. 1999;74(6):543\u201352.","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"3149_CR5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1530\/ERC-14-0254","volume":"21","author":"F Haller","year":"2014","unstructured":"Haller F, Moskalev EA, Faucz FR, Barthelme\u00df S, Wiemann S, Bieg M, et\u00a0al. Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad. Endocr Relat Cancer. 2014;21(4):567\u201377.","journal-title":"Endocr Relat Cancer"},{"issue":"8","key":"3149_CR6","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1210\/jc.2007-0797","volume":"92","author":"L Matyakhina","year":"2007","unstructured":"Matyakhina L, Bei TA, McWhinney SR, Pasini B, Cameron S, Gunawan B, et\u00a0al. Genetics of Carney triad: recurrent losses at chromosome 1 but lack of germline mutations in genes associated with paragangliomas and gastrointestinal stromal tumors. J Clin Endocrinol Metab. 2007;92(8):2938\u201343.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3149_CR7","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/ejhg.2015.142","volume":"24","author":"SA Boikos","year":"2016","unstructured":"Boikos SA, Xekouki P, Fumagalli E, Faucz FR, Raygada M, Szarek E, et\u00a0al. Carney triad can be (rarely) associated with germline succinate dehydrogenase defects. Eur J Hum Genet. 2016;24(4):569\u201373.","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"3149_CR8","first-page":"192","volume":"7","author":"G Nv","year":"2017","unstructured":"Nv G, As P, Kc P, Rc M. Carney\u2019s triad. J Case Rep. 2017;7(2):192\u20135.","journal-title":"J Case Rep"},{"key":"3149_CR9","unstructured":"Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic [Internet]. [cited 2020 Oct 13]. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5455315\/."},{"issue":"8","key":"3149_CR10","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1097\/PAS.0b013e318285f6a2","volume":"37","author":"JA Carney","year":"2013","unstructured":"Carney JA, Stratakis CA, Young WFJ. Adrenal cortical adenoma: the fourth component of the Carney triad and an association with subclinical Cushing syndrome. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no competing interests to declare regarding publication of this report","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"559"}}