{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:28:12Z","timestamp":1789604892309,"version":"build-2803163510"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Context<\/jats:title>\n                <jats:p>Dermatomyositis is a rare autoimmune disease characterized by noninfectious inflammatory damage of skin and predominant muscles in the belts. It is believed to be associated with about 1 in 1000 cases of nasopharyngeal carcinoma. This association has been described for locally advanced stages II and III nasopharyngeal carcinoma. It has rarely been described in the early stages (stage I).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 65-year-old Moroccan patient residing in Casablanca, with no particular history was referred to the Mohamed VI Center for the treatment of cancers of the University Hospital Center IBN ROCHD in Casablanca, for treatment of nasopharyngeal cancer. He was admitted in poor general condition, performance status 3, with erythema on the face, neck, and extremities. The diagnosis of paraneoplastic dermatomyositis was made owing to progressive muscle weakness and elevation of muscle enzymes associated with the typical rash of the face and hands. He received corticosteroid therapy and then radiotherapy to the nasopharynx with good clinical outcome, disappearance of skin lesions, and recovery of muscle strength.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We report this case of dermatomyositis in early-stage nasopharyngeal carcinoma, which is a rarely described entity. Rapid treatment of dermatomyositis improved the patient\u2019s quality of life and enabled him to support specific cancer treatments. This can be used as an element of early diagnosis and monitoring after treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03154-0","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:03:43Z","timestamp":1641254623000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Paraneoplastic dermatomyositis revealing undifferentiated nasopharyngeal carcinoma at early stage: a case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Souleymane","family":"Panandtigri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nioka Pierre Xavier","family":"Sia\u02e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryeme","family":"Charkaoui\u02e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Benchakroun\u02e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zineb","family":"Bouchbika\u02e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Jouhadi\u02e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nezha","family":"Tawfiq\u02e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souha","family":"Sahraoui\u02e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellatif","family":"Benider\u02e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"3154_CR1","unstructured":"Brigitte Bader-Meunier and Olivier Benveniste. National Diagnostic and Care Protocol (PNDS) Child and Adult Dermatomyositis. July 2016. 10th www.has-sante.fr."},{"issue":"9250","key":"3154_CR2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0140-6736(00)03540-6","volume":"357","author":"CL Hill","year":"2001","unstructured":"Hill CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, Evans SR, Felson DT. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet (London, England). 2001;357(9250):96\u2013100. https:\/\/doi.org\/10.1016\/S0140-6736(00)03540-6.","journal-title":"Lancet (London, England)"},{"key":"3154_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.11604\/pamj.2016.24.29.4822","volume":"24","author":"FZ Ziani","year":"2016","unstructured":"Ziani FZ, Brahmi SA, Najib R, Kanab R, Arifi S, Mernissi FZ, Mellas N. Paraneoplastic dermatomyositis revealing an undifferentiated nasopharyngeal carcinoma: about a case. Pan Afr Med J. 2016;24:29. https:\/\/doi.org\/10.11604\/pamj.2016.24.29.4822.","journal-title":"Pan Afr Med J"},{"issue":"3","key":"3154_CR4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.anorl.2010.10.007","volume":"128","author":"A Chakroun","year":"2011","unstructured":"Chakroun A, Guigay J, Lusinchi A, Marandas P, Janot F, Hartl DM. Paraneoplastic dermatomyositis accompanying nasopharyngeal carcinoma: diagnosis, treatment and prognosis. Eur Ann Otorhinolaryngol Head Neck Dis. 2011;128(3):127\u201331. https:\/\/doi.org\/10.1016\/j.anorl.2010.10.007.","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"issue":"4","key":"3154_CR5","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1177\/000348949710600416","volume":"106","author":"MA Vasef","year":"1997","unstructured":"Vasef MA, Ferlito A, Weiss LM. Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein-Barr virus. Ann Otol Rhinol Laryngol. 1997;106(4):348\u201356. https:\/\/doi.org\/10.1177\/000348949710600416.","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"5","key":"3154_CR6","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.anl.2008.10.006","volume":"36","author":"C Toro","year":"2009","unstructured":"Toro C, Rinaldo A, Silver CE, Politi M, Ferlito A. Paraneoplastic syndromes in patients with nasopharyngeal cancer. Auris Nasus Larynx. 2009;36(5):513\u201320. https:\/\/doi.org\/10.1016\/j.anl.2008.10.006.","journal-title":"Auris Nasus Larynx"},{"key":"3154_CR7","first-page":"471","volume":"14","author":"M Maalej","year":"1985","unstructured":"Maalej M, Ladgham A, Ennouri A, BenAttia A, Cammoun M, Ellouze R. The paraneoplastic syndrome in nasopharynx cancer. 32 boxes. Presse Medicale. 1985;14:471\u20134.","journal-title":"Presse Medicale"},{"key":"3154_CR8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1056\/NEJM197502132920706","volume":"292","author":"A Bohan","year":"1975","unstructured":"Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975;292:344\u20137. https:\/\/doi.org\/10.1056\/NEJM197502132920706.","journal-title":"N Engl J Med"},{"issue":"7","key":"3154_CR9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1365-4362.1985.tb05816.x","volume":"24","author":"HL Chan","year":"1985","unstructured":"Chan HL. Dermatomyositis and cancer in Singapore. Int J Dermatol. 1985;24(7):447\u201350. https:\/\/doi.org\/10.1111\/j.1365-4362.1985.tb05816.x.","journal-title":"Int J Dermatol"},{"key":"3154_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/00000421-199602000-00008","volume":"19","author":"W Hu","year":"1996","unstructured":"Hu W, Chen DL, Min HQ. Study of 45 cases of nasopharyngeal carcinoma with dermatomyositis. Am J Clin Oncol. 1996;19:35\u20138. https:\/\/doi.org\/10.1097\/00000421-199602000-00008.","journal-title":"Am J Clin Oncol"},{"key":"3154_CR11","first-page":"26","volume":"13","author":"F Frikha","year":"2012","unstructured":"Frikha F, Snoussi M, Salah RB, Saidi N, Kaddour N, Bahloul Z. Dermatomyositis in the elderly: a study of 4 cases in southern Tunisia. Pan Afr Med J. 2012;13:26.","journal-title":"Pan Afr Med J"},{"issue":"1","key":"3154_CR12","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.autrev.2011.06.007","volume":"11","author":"I Mary","year":"2011","unstructured":"Mary I, Mouthon L. Therapy of polymyositis and dermatomyositis. Autoimmun Rev. 2011;11(1):6\u201313. https:\/\/doi.org\/10.1016\/j.autrev.2011.06.007.","journal-title":"Autoimmun Rev"},{"key":"3154_CR13","first-page":"9","volume":"29","author":"P Ch\u00e9rin","year":"2008","unstructured":"Ch\u00e9rin P. Current therapy for polymyositis and dermatomyositis. Internal Med Rev. 2008;29:9\u201314.","journal-title":"Internal Med Rev"},{"issue":"2","key":"3154_CR14","first-page":"241","volume":"18","author":"E Pautas","year":"2000","unstructured":"Pautas E, Ch\u00e9rin P, Piette JC, Pelletier S, Wechsler B, Cabane J, Herson S. Features of polymyositis and dermatomyositis in the elderly: a case\u2013control study. Clin Exp Rheumatol. 2000;18(2):241\u20134.","journal-title":"Clin Exp Rheumatol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03154-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-03154-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03154-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:05:03Z","timestamp":1641254703000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-03154-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3154"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-03154-0","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]},"assertion":[{"value":"1 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent has been obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors do not declare any conflict of interest","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3"}}