{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:27:39Z","timestamp":1790681259175,"version":"4.1.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences","award":["980203554"],"award-info":[{"award-number":["980203554"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Escherichia\u00a0coli<\/jats:italic> has appeared as an important opportunistic pathogen responsible for nosocomial infections in patients with immunodeficiency, particularly in leukemia patients. New Delhi metallo-beta-lactamase is an enzyme originally found in Enterobacteriaceae.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In this study, 80 isolates of <jats:italic>Escherichia\u00a0coli<\/jats:italic> and <jats:italic>Klebsiella\u00a0pneumoniae<\/jats:italic> were collected over the course of 2\u00a0years from two medical centers in Tehran, Iran. Production of carbapenemase was detected in the isolates using modified Hodge test. New Delhi metallo-beta-lactamase-1 genes were detected by polymerase chain reaction amplification with specific primers. Two New Delhi metallo-beta-lactamase-1-producing <jats:italic>Escherichia\u00a0coli<\/jats:italic> strains were isolated from two Iranian patients with leukemia. These two patients were 6 and 15\u00a0years old, one female and the other male, from two oncology centers in Iran. The isolates were resistant to carbapenems (imipenem, meropenem), and two isolates were positive for carbapenemase production by modified Hodge test.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The emergence of New Delhi metallo-beta-lactamase-1-producing <jats:italic>Escherichia\u00a0coli<\/jats:italic> is a threat for leukemia patients in oncology and hematology departments. We conclude that the incidence of multidrug resistant pathogens has increased among patients with leukemia and is life threatening.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03160-2","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T11:07:49Z","timestamp":1637838469000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Delhi metallo-\u03b2-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports"],"prefix":"10.1186","volume":"15","author":[{"given":"Mahdane","family":"Roshani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Dehbashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Afrasiabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-8193","authenticated-orcid":false,"given":"Mohammad Reza","family":"Arabestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"issue":"12","key":"3160_CR1","doi-asserted-by":"publisher","first-page":"5046","DOI":"10.1128\/AAC.00774-09","volume":"53","author":"D Yong","year":"2009","unstructured":"Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, et\u00a0al. Characterization of a new metallo-\u03b2-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 2009;53(12):5046\u201354.","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"3160_CR2","doi-asserted-by":"publisher","first-page":"531","DOI":"10.5001\/omj.2017.102","volume":"32","author":"NK Devaraj","year":"2017","unstructured":"Devaraj NK. Antibiotic resistance: a real menace. Oman Med J. 2017;32(6):531.","journal-title":"Oman Med J"},{"issue":"2","key":"3160_CR3","first-page":"187","volume":"74","author":"NK Devaraj","year":"2019","unstructured":"Devaraj NK, Aneesa A, Abdul Hadi A, Shaira N. Topical corticosteroids in clinical practice. 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IR.UMSHA.REC.1398.004).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patients\u201d legal guardian for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"567"}}