{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:24:33Z","timestamp":1790915073934,"version":"4.1.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>An adrenocortical tumor is a rare tumor in pediatrics, which can be functional or nonfunctional. Functional tumors present with virilization, feminization, or hypercortisolism. Feminizing adrenal tumors, though rare in pediatrics, need to be excluded in any child presenting with features of feminization. \n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a case of a 4-year-old\u00a0Sudanese girl who presented with gradually progressive bilateral breast enlargement and accelerated growth since the age of 6\u00a0months. The family had sought medical advice several times in numerous health facilities without much gain. Investigations showed pubertal luteinizing hormone levels, high estradiol E2, and dehydroepiandrosterone sulfate, with normal early morning cortisol level. Abdominal ultrasound revealed a right-sided hypoechoic suprarenal mass. Abdominal computed tomography scan showed a right adrenal mass. The diagnosis of feminizing adrenal neoplasm was confirmed and right adrenalectomy was done. Histopathological examination of the resected adrenal gland showed adrenocortical adenoma. The patient was started on gonadotrophin-releasing hormone agonist for secondary central precocious puberty.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Adrenocortical tumors, though rare in pediatrics, are a documented cause of precocious puberty; biochemical and imaging screening protocol should be adopted for patients with precocious puberty, even in a resource-limited setting, for early detection and treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-021-03203-8","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:03:35Z","timestamp":1640045015000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Feminizing adrenocortical adenoma in a girl from a resource-limited setting: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-8629","authenticated-orcid":false,"given":"Eman Abdalla Ali","family":"Elnaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej Ahmed Bashier","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ahmed","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"issue":"7\u20138","key":"3203_CR1","first-page":"535","volume":"24","author":"QL Chen","year":"2011","unstructured":"Chen QL, Su Z, Li YH, Ma HM, Chen HS, Du ML. Clinical characteristics of adrenocortical tumors in children. J Pediatr Endocrinol Metab. 2011;24(7\u20138):535\u201341.","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"3","key":"3203_CR2","doi-asserted-by":"publisher","first-page":"332","DOI":"10.4103\/2230-8210.152764","volume":"19","author":"F Chentli","year":"2015","unstructured":"Chentli F, Bekkaye I, Azzoug S. Feminizing adrenocortical tumors: literature review. Indian J Endocrinol Metab. 2015;19(3):332\u20139.","journal-title":"Indian J Endocrinol Metab."},{"issue":"2","key":"3203_CR3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ecl.2017.01.007","volume":"46","author":"M Lodish","year":"2017","unstructured":"Lodish M. Genetics of adrenocortical development and tumors. Endocrinol Metab Clin North Am. 2017;46(2):419\u201333.","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"1","key":"3203_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13244-019-0688-8","volume":"10","author":"D Albano","year":"2019","unstructured":"Albano D, Agnello F, Midiri F, Pecoraro G, Bruno A, Alongi P, et al. Imaging features of adrenal masses. Insights Imaging. 2019;10(1):1.","journal-title":"Insights Imaging"},{"issue":"1","key":"3203_CR5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/his.13255","volume":"72","author":"LA Erickson","year":"2018","unstructured":"Erickson LA. Challenges in surgical pathology of adrenocortical tumours. Histopathology. 2018;72(1):82\u201396.","journal-title":"Histopathology"},{"issue":"4","key":"3203_CR6","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1053\/jpsu.2001.22280","volume":"36","author":"AO Ciftci","year":"2001","unstructured":"Ciftci AO, \u015eenocak ME, Tanyel FC, B\u00fcy\u00fckpamuk\u00e7u N. Adrenocortical tumors in children. J Pediatr Surg. 2001;36(4):549\u201354.","journal-title":"J Pediatr Surg"},{"issue":"1","key":"3203_CR7","first-page":"32","volume":"4","author":"JA Sutter","year":"2006","unstructured":"Sutter JA, Grimberg A. Adrenocortical tumors and hyperplasias in childhood\u2013etiology, genetics, clinical presentation and therapy. Pediatr Endocrinol Rev. 2006;4(1):32\u20139.","journal-title":"Pediatr Endocrinol Rev"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03203-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-021-03203-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-021-03203-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:03:52Z","timestamp":1640045032000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-021-03203-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3203"],"URL":"https:\/\/doi.org\/10.1186\/s13256-021-03203-8","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"23 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We declare that we have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"605"}}