{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:05:03Z","timestamp":1785150303368,"version":"3.55.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Tumor lysis syndrome is an oncologic emergency that classically occurs following cancer therapy, although spontaneous tumor lysis syndrome can also occur in malignancies, albeit rarely. Spontaneous tumor lysis syndrome has previously been reported in some hematologic malignancies, but it rarely happens in solid tumors and seems to be associated with a higher mortality rate. This is the first case of adrenal adenocarcinoma that developed spontaneous tumor lysis syndrome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a rare case of spontaneous tumor lysis syndrome occurring in a patient previously diagnosed with adrenal adenocarcinoma. The patient was a 64-year-old Persian man with abdominal pain, hypersomnia, and fatigue who was previously diagnosed with right adrenocortical carcinoma and had undergone right adrenalectomy with regional lymph nodes resection 5 months previously. On physical examination, the patient had abdominal distension and mild tenderness at the right upper quadrant. Pitting edema was detected bilaterally in the lower extremities. Initial imaging revealed multiple and large lesions suggestive of liver metastases. The laboratory data showed hyperkalemia, hyperuricemia, hyperphosphatemia, and elevated serum creatinine level indicative of spontaneous tumor lysis syndrome in the patient. Despite immediate and intensive care with antibiotics, hydration, treatment with a hypouricemic agent, and renal replacement therapy, the patient ultimately died from multiorgan failure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Tumor lysis syndrome in solid tumors has high mortality. Patients susceptible to spontaneous tumor lysis syndrome must receive aggressive treatment immediately, which is crucial for preventing morbidity and mortality. Spontaneous tumor lysis syndrome may be underdiagnosed, and a high degree of clinical suspicion is needed to make the diagnosis and proceed with required interventions. Therefore, clinicians should be aware of this rare phenomenon.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-022-03263-4","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:02:44Z","timestamp":1644451364000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Spontaneous tumor lysis syndrome in adrenal adenocarcinoma: a case report and review of the\u00a0literature"],"prefix":"10.1186","volume":"16","author":[{"given":"Mahan","family":"Shafie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Teymouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Parsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sadeghian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narjes","family":"Zarei Jalalabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"issue":"3","key":"3263_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/20009666.2020.1761185","volume":"10","author":"I Puri","year":"2020","unstructured":"Puri I, Sharma D, Gunturu KS, Ahmed AA. Diagnosis and management of tumor lysis syndrome. J Community Hosp Intern Med Perspect. 2020;10(3):269\u201372.","journal-title":"J Community Hosp Intern Med Perspect."},{"issue":"19","key":"3263_CR2","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1056\/NEJMra0904569","volume":"364","author":"SC Howard","year":"2011","unstructured":"Howard SC, Jones DP, Pui CH. The tumor lysis syndrome. N Engl J Med. 2011;364(19):1844\u201354.","journal-title":"N Engl J Med"},{"issue":"12","key":"3263_CR3","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1002\/ccr3.1269","volume":"5","author":"D Sommerhalder","year":"2017","unstructured":"Sommerhalder D, Takalkar AM, Shackelford R, Peddi P. Spontaneous tumor lysis syndrome in colon cancer: a case report and literature review. Clin Case Rep. 2017;5(12):2121\u20136. https:\/\/doi.org\/10.1002\/ccr3.1269.","journal-title":"Clin Case Rep."},{"issue":"1","key":"3263_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1365-2141.2004.05094.x","volume":"127","author":"MS Cairo","year":"2004","unstructured":"Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127(1):3\u201311.","journal-title":"Br J Haematol"},{"issue":"3","key":"3263_CR5","doi-asserted-by":"publisher","first-page":"142","DOI":"10.4103\/2452-2473.290061.eCollection2020Jul-Sep","volume":"20","author":"AM Alan","year":"2020","unstructured":"Alan AM, Alan O. A case of spontaneous tumor lysis syndrome in extensive-stage small-cell lung cancer: a rare oncologic emergency. Turk J Emerg Med. 2020;20(3):142\u20135. https:\/\/doi.org\/10.4103\/2452-2473.290061.eCollection2020Jul-Sep.","journal-title":"Turk J Emerg Med."},{"issue":"2","key":"3263_CR6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4081\/rt.2014.5389","volume":"6","author":"AE Mirrakhimov","year":"2014","unstructured":"Mirrakhimov AE, Ali AM, Khan M, Barbaryan A. Tumor lysis syndrome in solid tumors: an up to date review of the literature. Rare Tumors. 2014;6(2):13.","journal-title":"Rare Tumors."},{"issue":"5","key":"3263_CR7","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1590\/s1807-59322009000500016","volume":"64","author":"M Soares","year":"2009","unstructured":"Soares M, Feres GA, Salluh JI. Systemic inflammatory response syndrome and multiple organ dysfunction in patients with acute tumor lysis syndrome. Clinics (Sao Paulo). 2009;64(5):479\u201381. https:\/\/doi.org\/10.1590\/s1807-59322009000500016.","journal-title":"Clinics (Sao Paulo)."},{"issue":"1","key":"3263_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3324\/haematol.12327","volume":"93","author":"J Hochberg","year":"2008","unstructured":"Hochberg J, Cairo MS. Tumor lysis syndrome: current perspective. Haematologica. 2008;93(1):9\u201313. https:\/\/doi.org\/10.3324\/haematol.12327.","journal-title":"Haematologica"},{"issue":"5","key":"3263_CR9","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/bjh.13403","volume":"169","author":"GL Jones","year":"2015","unstructured":"Jones GL, Will A, Jackson GH, Webb NJA, Rule S. Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology. British Journal of Haematology. 2015;169(5):661\u201371.","journal-title":"British Journal of Haematology."},{"issue":"10","key":"3263_CR10","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.clon.2006.09.005","volume":"18","author":"C Gemici","year":"2006","unstructured":"Gemici C. Tumour lysis syndrome in solid tumours. Clin Oncol. 2006;18(10):773\u201380.","journal-title":"Clin Oncol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03263-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-022-03263-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03263-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:04:01Z","timestamp":1644451441000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-022-03263-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3263"],"URL":"https:\/\/doi.org\/10.1186\/s13256-022-03263-4","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]},"assertion":[{"value":"20 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the research and ethics committee of Tehran University of Medical Sciences. The patient\u2019s family gave informed consent to publish this case.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s next of kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflict of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"52"}}