{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:40:58Z","timestamp":1787020858329,"version":"build-2736575974"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis B virus infection is a global public health problem. Although hepatitis B virus primarily affects hepatocytes, it sometimes develops disease manifestations outside the liver, such as myopathy, which is commonly caused by chronic hepatitis B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This case report describes a 57-year-old Iranian woman admitted to the hospital with jaundice, fever, body itching, abdominal pain, progressive muscle weakness, icteric sclera, right upper quadrant pain, and decreased muscle force. Examination on the first day of admission revealed that the patient was negative for hepatitis D antibody, positive for hepatitis B core (IgM) antibody, positive for hepatitis B surface antigen, and negative for hepatitis B e antibody but positive for hepatitis B e antigen. Moreover, she showed high levels of hepatitis B virus DNA viral load, creatine kinase, lactate dehydrogenase, serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, total bilirubin, direct bilirubin, and alkaline phosphatase, and electromyography\/nerve conduction velocity showed acute myopathic process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Interestingly, myopathy symptoms improved after improving hepatitis symptoms and decreasing hepatitis B viral load, suggesting a close association between hepatitis B infection and myopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-022-03330-w","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T19:03:21Z","timestamp":1649444601000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of acute hepatitis B and acute myopathy: a case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Mehrangiz","family":"Zangeneh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoomeh","family":"Mesgarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-3908","authenticated-orcid":false,"given":"Yasamin","family":"Khosravani-Nezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"3330_CR1","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1016\/0264-410X(90)90209-5","volume":"8","author":"JE Maynard","year":"1990","unstructured":"Maynard JE. Hepatitis B: global importance and need for control. Vaccine. 1990;8:S18\u201320.","journal-title":"Vaccine"},{"issue":"12","key":"3330_CR2","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/j.vaccine.2011.12.116","volume":"30","author":"JJ Ott","year":"2012","unstructured":"Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30(12):2212\u20139.","journal-title":"Vaccine"},{"issue":"3","key":"3330_CR3","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1572-0241.1998.00354.x","volume":"93","author":"Y-F Liaw","year":"1998","unstructured":"Liaw Y-F, Tsai S-L, Sheen IS, Chato M, Yeh C-T, Hsieh S-Y, et\u00a0al. Clinical and virological course of chronic hepatitis B virus infection with hepatitis C and D virus markers. Am J Gastroenterol. 1998;93(3):354\u20139.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"3330_CR4","first-page":"123","volume":"9","author":"MR Kappus","year":"2013","unstructured":"Kappus MR, Sterling RK. Extrahepatic manifestations of acute hepatitis B virus infection. Gastroenterol Hepatol (N Y). 2013;9(2):123\u20136.","journal-title":"Gastroenterol Hepatol (N Y)."},{"issue":"1","key":"3330_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11894-001-0044-1","volume":"3","author":"NT Pyrsopoulos","year":"2001","unstructured":"Pyrsopoulos NT, Reddy KR. Extrahepatic manifestations of chronic viral hepatitis. Curr Gastroenterol Rep. 2001;3(1):71\u20138.","journal-title":"Curr Gastroenterol Rep"},{"key":"3330_CR6","first-page":"49","volume":"2","author":"J Chawla","year":"2011","unstructured":"Chawla J. Stepwise approach to myopathy in systemic disease. Front Neurol. 2011;2:49.","journal-title":"Front Neurol"},{"issue":"4","key":"3330_CR7","doi-asserted-by":"publisher","first-page":"417","DOI":"10.7326\/0003-4819-87-4-417","volume":"87","author":"BM Patten","year":"1977","unstructured":"Patten BM, Shabot JM, Alperin J, Dodson RF. Hepatitis-associated lipid storage myopathy. Ann Intern Med. 1977;87(4):417\u201321.","journal-title":"Ann Intern Med"},{"issue":"1","key":"3330_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/CND.0b013e3181df2b2b","volume":"13","author":"J-P St\u00fcbgen","year":"2011","unstructured":"St\u00fcbgen J-P. Neuromuscular disorders associated with hepatitis B virus infection. J Clin Neuromusc Dis. 2011;13(1):26.","journal-title":"J Clin Neuromusc Dis"},{"issue":"15","key":"3330_CR9","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1001\/jama.1980.03300410014012","volume":"243","author":"E Flatau","year":"1980","unstructured":"Flatau E, Resnitzky P, Kohn D. Hepatitis B antigen associated with cryoglobulinemia, peripheral neuropathy, and myopathy. JAMA. 1980;243(15):1526.","journal-title":"JAMA."},{"issue":"8","key":"3330_CR10","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1212\/01.wnl.0000240078.47020.5e","volume":"67","author":"M Capasso","year":"2006","unstructured":"Capasso M, Di Muzio A, Comar M, Robuffo I, Gambi A, Crovella S, et\u00a0al. The association of chronic hepatitis B and myopathy. Neurology. 2006;67(8):1467.","journal-title":"Neurology"},{"issue":"3","key":"3330_CR11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.14309\/crj.2014.39","volume":"1","author":"K Thanapirom","year":"2014","unstructured":"Thanapirom K, Aniwan S, Treeprasertsuk S. Polymyositis associated with hepatitis B virus cirrhosis and advanced hepatocellular carcinoma. ACG Case Rep J. 2014;1(3):167\u20139.","journal-title":"ACG Case Rep J"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03330-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-022-03330-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03330-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T19:03:30Z","timestamp":1649444610000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-022-03330-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,9]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3330"],"URL":"https:\/\/doi.org\/10.1186\/s13256-022-03330-w","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,9]]},"assertion":[{"value":"7 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The manuscript ethics was performed in accordance with the Declaration of Helsinki; however, ethical approval is not required at Amiralmomenin Medical School Hospital to publish an anonymous case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"143"}}