{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:44:42Z","timestamp":1790801082959,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Giant parathyroid adenoma is a type of parathyroid adenoma weighing &gt;\u20093.5\u00a0g and having a size of more than 2\u00a0cm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This report describes giant primary parathyroid adenoma with reference to the literature. We report the case of a 48-year-old Persian man referred to the clinic with knee and lower back pain. He had a history of mitral valve replacement and several episodes of bilateral nephrolithiasis. After a thorough assessment, a neck mass with a possible thyroid origin was detected, but further assessment showed it was of parathyroid origin. The resected mass was 9\u2009\u00d7\u20096\u00d7\u20094\u00a0cm and weighed 122\u00a0g, and histopathology showed a giant parathyroid adenoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Giant parathyroid adenomas that weigh more than 110\u00a0g and are larger than 8\u00a0cm can lead to significant hypercalcemia. Despite giant parathyroid adenomas and high parathyroid hormone levels, a calcium crisis may not always occur in these patients, and the masses may be initially misdiagnosed as a thyroid mass.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-022-03401-y","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T19:03:54Z","timestamp":1649790234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Giant parathyroid adenoma: a case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Rahim","family":"Mahmodlou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-3309","authenticated-orcid":false,"given":"Amin","family":"Sedokani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apameh","family":"Pezeshk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Najafinejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"3401_CR1","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.surg.2013.05.013","volume":"154","author":"PM Spanheimer","year":"2013","unstructured":"Spanheimer PM, Stoltze AJ, Howe JR, Sugg SL, Lal G, Weigel RJ. Do giant parathyroid adenomas represent a distinct clinical entity? Surgery. 2013;154:714\u20139.","journal-title":"Surgery"},{"key":"3401_CR2","first-page":"669","volume":"55","author":"RM Neagoe","year":"2014","unstructured":"Neagoe RM, Sala DT, Borda A, Mogoanta CA, Muhlfay G. Clinicopathologic and therapeutic aspects of giant parathyroid adenomas\u2014three case reports and short review of the literature. Rom J Morphol Embryol. 2014;55:669\u201374.","journal-title":"Rom J Morphol Embryol"},{"issue":"2","key":"3401_CR3","first-page":"101","volume":"7","author":"MT Salehian","year":"2009","unstructured":"Salehian MT, Namdari O, Mohammadi SS, Yousofabad HF. Primary hyperparathyroidism due to a giant parathyroid adenoma: a case report. 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The patient signed an informed consent form approved by the ethics committee of both Imam Hospital and Urmia University of Medical Sciences.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient to publish this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"150"}}