{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T23:41:39Z","timestamp":1653781299195},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hereditary hemorrhagic telangiectasia, also known as Osler\u2013Weber\u2013Rendu disease, induces arteriovenous malformations in visceral organs. Arteriovenous malformations increase the risk of severe infections and are a common complication associated with hemorrhagic telangiectasia. However, cases of endocarditis associated with hemorrhagic telangiectasia are rarely reported. Although hemorrhagic telangiectasia causes erythematous macules on the extremities, these macules are usually painless. We encountered a rare case of infective endocarditis in a patient with Osler\u2013Weber\u2013Rendu disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 52-year-old Japanese woman who was diagnosed with hemorrhagic telangiectasia 5 years prior presented to our hospital with fever and muscular pain. She had erythematous nodules and tenderness on the finger, heel, and toe, suggestive of Osler\u2019s nodes. A physical examination revealed tachycardia with a 3\/6 pansystolic murmur. A transesophageal echocardiogram showed vegetations along the atrial side of the mitral valve and mild mitral regurgitation because of prolapse of the anterior commissure. Methicillin-sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> was identified in the blood cultures. Detection of distinctive skin lesions, so-called Osler\u2019s nodes, was the symptomatic key to early diagnosis, and the patient was treated without surgery. She was discharged with negative blood cultures after a 6-week intravenous antibiotic administration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our report highlights the importance of considering the risk of extracerebral infections including endocarditis in hemorrhagic telangiectasia. This rare case effectively demonstrates the importance of proper diagnosis of skin lesions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-022-03427-2","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T23:03:33Z","timestamp":1653779013000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infective endocarditis with Osler\u2019s nodule in a patient with Osler\u2019s disease: a case report and review of the\u00a0literature"],"prefix":"10.1186","volume":"16","author":[{"given":"Genki","family":"Naruse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatomo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Okura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"3427_CR1","first-page":"221","volume":"50","author":"C Sabb\u00e0","year":"2002","unstructured":"Sabb\u00e0 C, Pasculli G, Cirulli A, Gallitelli M, Virgilio G, Resta F, et al. Hereditary hemorrhagic teleangiectasia (Rendu-Osler-Weber disease). Minerva Cardioangiol. 2002;50:221\u201338.","journal-title":"Minerva Cardioangiol"},{"key":"3427_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/01.GIM.0000132689.25644.7C","volume":"6","author":"P Bayrak-Toydemir","year":"2004","unstructured":"Bayrak-Toydemir P, Mao R, Lewin S, McDonald J. Hereditary hemorrhagic telangiectasia: an overview of diagnosis and management in the molecular era for clinicians. Genet Med. 2004;6:175\u201391.","journal-title":"Genet Med"},{"key":"3427_CR3","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P","volume":"91","author":"CL Shovlin","year":"2000","unstructured":"Shovlin CL, Guttmacher AE, Buscarini E, Faughnan ME. Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Am J Med Genet. 2000;91:66\u20137.","journal-title":"Am J Med Genet"},{"key":"3427_CR4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1159\/000081053","volume":"24","author":"M Gallitelli","year":"2005","unstructured":"Gallitelli M, Lepore V, Pasculli G, Di Gennaro L, Logroscino G, Carella A, et al. Brain abscess: a need to screen for pulmonary arteriovenous malformations. Neuroepidemiology. 2005;24:76\u20138.","journal-title":"Neuroepidemiology"},{"key":"3427_CR5","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S0248-8663(99)80070-8","volume":"19","author":"P Blanco","year":"1998","unstructured":"Blanco P, Schaeverbeke T, Baillet L, Lequen L, Bannwarth B, Dehais J. Rendu-Osler familial telangiectasia angiomatosis and bacterial spondylodiscitis [in French]. Rev Med Interne. 1998;19:938\u20139.","journal-title":"Rev Med Interne"},{"key":"3427_CR6","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0002-9343(01)00709-4","volume":"110","author":"X Duval","year":"2001","unstructured":"Duval X, Djendli S, Le Moing V, Longuet P, Barry B, Leport C, et al. Recurrent Staphylococcus aureus extracerebral infections complicating hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease). Am J Med. 2001;110:671\u20132.","journal-title":"Am J Med"},{"key":"3427_CR7","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1086\/511645","volume":"44","author":"GS Dupuis","year":"2007","unstructured":"Dupuis GS, Giraud S, Decullier E, Lesca G, Cottin V, Faure F, et al. Hemorrhagic hereditary telangiectasia (Rendu-Osler disease) and infectious diseases: an underestimated association. Clin Infect Dis. 2007;44:841\u20135.","journal-title":"Clin Infect Dis"},{"key":"3427_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/joim.12098","volume":"274","author":"A Guilhem","year":"2013","unstructured":"Guilhem A, Malcus C, Clarivet B, Plauchu H, Dupuis-Girod S. Immunological abnormalities associated with hereditary haemorrhagic telangiectasia. J Intern Med. 2013;274:351\u201362.","journal-title":"J Intern Med"},{"key":"3427_CR9","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1536\/jhj.45.885","volume":"45","author":"S Ishikawa","year":"2004","unstructured":"Ishikawa S, Oshima K, Aizaki M, Takahashi T, Hasegawa Y, Morishita Y. A second mitral valve replacement in a patient with hereditary hemorrhagic telangiectasia (Osler\u2019s disease). Jpn Heart J. 2004;45:885\u20138.","journal-title":"Jpn Heart J"},{"key":"3427_CR10","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.medmal.2010.12.019","volume":"41","author":"C Bally","year":"2011","unstructured":"Bally C, Meyssonnier V, Bricaire F. Infections r\u00e9cidivantes \u00e0 Staphylococcus aureus [in French]. Med Mal Infect. 2011;41:346\u20138.","journal-title":"Med Mal Infect"},{"key":"3427_CR11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/icvts\/ivs230","volume":"15","author":"A Castiglioni","year":"2012","unstructured":"Castiglioni A, Pozzoli A, Maisano F, Alfieri O. Endocarditis after transfemoral aortic valve implantation in a patient with Osler-weber-Rendu syndrome. Interact Cardiovasc Thorac Surg. 2012;15:553\u20134.","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"3427_CR12","first-page":"50","volume":"22","author":"M Musso","year":"2014","unstructured":"Musso M, Capone A, Chinello P, Di Bella S, Galati V, Noto P, et al. Extra-cerebral severe infections associated with haemorrhagic hereditary telangiectasia (Rendu-Osler-Weber Disease): five cases and a review of the literature. Infez Med. 2014;22:50\u20136.","journal-title":"Infez Med"},{"key":"3427_CR13","doi-asserted-by":"publisher","first-page":"702","DOI":"10.5761\/atcs.cr.12.01933","volume":"20","author":"H Morita","year":"2014","unstructured":"Morita H, Kimura N, Yuri K, Adachi K, Yamaguchi A, Adachi H. Bentall operation for prosthetic valve endocarditis with hereditary hemorrhagic telangiectasia. Ann Thorac Cardiovasc Surg. 2014;20:702\u20134.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"3427_CR14","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1007\/s00595-014-0876-6","volume":"44","author":"Y Nakamura","year":"2014","unstructured":"Nakamura Y, Shikata F, Ryugo M, Okamura T, Yasugi T, Izutani H. Redo cardiac surgery for active prosthetic valve endocarditis associated with hereditary hemorrhagic telangiectasia: report of a case. Surg Today. 2014;44:2378\u201381.","journal-title":"Surg Today"},{"key":"3427_CR15","first-page":"383","volume":"24","author":"Y Konishi","year":"2015","unstructured":"Konishi Y, Sakon Y, Nakamura K, Fukunaga N, Kanemitsu H, Koyama T. Pulmonary valvuloplasty by autologous pericardium in a patient with active infectious endocarditis and Osler\u2019s disease. J Heart Valve Dis. 2015;24:383\u20135.","journal-title":"J Heart Valve Dis"},{"key":"3427_CR16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12879-018-2956-5","volume":"18","author":"E Boumis","year":"2018","unstructured":"Boumis E, Capone A, Galati V, Venditti C, Petrosillo N. Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature. BMC Infect Dis. 2018;18:65.","journal-title":"BMC Infect Dis"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03427-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-022-03427-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03427-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T23:03:40Z","timestamp":1653779020000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-022-03427-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,29]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3427"],"URL":"https:\/\/doi.org\/10.1186\/s13256-022-03427-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,29]]},"assertion":[{"value":"8 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In our institution, institutional review board approval is not required for a case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"211"}}