{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:09:11Z","timestamp":1789697351126,"version":"4.0.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The Diego<jats:sup>a<\/jats:sup> antigen commonly occurs in certain Asian and South American Indian populations. In general, hemolysis caused by anti-Diego<jats:sup>a<\/jats:sup> antigen is not severe, and exchange transfusion is rarely needed. Here, we report a neonate with moderate hemolytic disease caused by anti-Diego<jats:sup>a<\/jats:sup> antigen in the Baoji area of China.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 39-week gestation\u00a0male  newborn of Han nationality\u00a0was delivered by second cesarean section because of scarred uterus. The newborn\u2019s birth weight was 3700\u00a0g with an Apgar score of 9. Four hours after delivery, transcutaneous bilirubin test revealed a level of 17\u00a0mg\/dl. After 23\u00a0hours, the neonate developed anemia and hyperbilirubinemia. Bacterium, virus and other pathogens, as well as tests for arcuate and glucose-6-phosphate dehydrogenase, were all negative. Direct antiglobulin test of the neonate was positive. Diego<jats:sup>a<\/jats:sup> antigens of the baby and his father were positive, while his mother was negative. The newborn was successfully cured with phototherapy and one-dose intravenous injection of human albumin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>It is important to consider and test for the anti-Diego<jats:sup>a<\/jats:sup> antibody in cases of hemolytic disease of the newborn of the Han ethnicities of China.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-022-03516-2","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T23:17:47Z","timestamp":1657667867000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal hemolytic disease due to anti-Diegoa antibody: a case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Yangxi","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"issue":"2","key":"3516_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.21307\/immunohematology-2019-128","volume":"29","author":"D Figueroa","year":"2013","unstructured":"Figueroa D. The Diego blood group system: a review. Immunohematology. 2013;29(2):73\u201381.","journal-title":"Immunohematology"},{"issue":"1","key":"3516_CR2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4103\/0973-6247.106725","volume":"7","author":"CT Wei","year":"2013","unstructured":"Wei CT, Al-Hassan FM, Naim N, Knight A, Joshi SR. Prevalence of Diego blood group antigen and the antibody in three ethnic population groups in Klang valley of Malaysia. Asian J Transfus Sci. 2013;7(1):26\u20138.","journal-title":"Asian J Transfus Sci"},{"key":"3516_CR3","first-page":"114","volume":"7","author":"M Layrisse","year":"1958","unstructured":"Layrisse M, Arends T. The Diego blood factor distribution; genetic, clinical and anthropological significance. Bibl Haematol. 1958;7:114\u20136.","journal-title":"Bibl Haematol"},{"issue":"1\u20132","key":"3516_CR4","first-page":"23","volume":"20","author":"HG Heuft","year":"1993","unstructured":"Heuft HG, Zeiler T, Zingsem J, Eckstein R. Sporadic occurrence of Diego A antigens and antibodies in Berlin. Infusionsther Transfusionsmed. 1993;20(1\u20132):23\u20135.","journal-title":"Infusionsther Transfusionsmed"},{"issue":"2","key":"3516_CR5","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1159\/000462181","volume":"62","author":"G Kusnierz-Alejska","year":"1992","unstructured":"Kusnierz-Alejska G, Bochenek S. Haemolytic disease of the newborn due to anti-Dia and incidence of the Dia antigen in Poland. Vox Sang. 1992;62(2):124\u20136.","journal-title":"Vox Sang"},{"issue":"4","key":"3516_CR6","first-page":"203","volume":"19","author":"C Thompson","year":"2006","unstructured":"Thompson C. Diego(a) antigen frequency and anti-Diego(a) frequency in a South Texas community. Clin Lab Sci. 2006;19(4):203\u20135.","journal-title":"Clin Lab Sci"},{"issue":"3","key":"3516_CR7","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/s12288-017-0886-9","volume":"34","author":"M Chesor","year":"2018","unstructured":"Chesor M, Mitundee S, Nathalang S, Thattanon P, Intharanut K, Tobunluepop P, Nathalang O. DI* A and DI* B allele frequencies among southern Thai blood donors. Indian J Hematol Blood Transfus. 2018;34(3):506\u20139.","journal-title":"Indian J Hematol Blood Transfus"},{"key":"3516_CR8","volume":"2015","author":"A Jethava","year":"2015","unstructured":"Jethava A, Olivares E, Shariatmadar S. A case of hemolytic disease of the newborn due to Di (a) antibody. Case Rep Pediatr. 2015;2015: 897803.","journal-title":"Case Rep Pediatr"},{"issue":"5","key":"3516_CR9","first-page":"347","volume":"10","author":"JY Ting","year":"2004","unstructured":"Ting JY, Ma ES, Wong KY. A case of severe haemolytic disease of the newborn due to anti-Di(a) antibody. Hong Kong Med J. 2004;10(5):347\u20139.","journal-title":"Hong Kong Med J"},{"issue":"5","key":"3516_CR10","first-page":"581","volume":"22","author":"ME Hinckley","year":"1979","unstructured":"Hinckley ME, Huestis DW. Case report. An immediate hemolytic transfusion reaction apparently caused by anti-Dia. Rev Fr Transfus Immunohematol. 1979;22(5):581\u20135.","journal-title":"Rev Fr Transfus Immunohematol"},{"issue":"3","key":"3516_CR11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1046\/j.1537-2995.1982.22382224952.x","volume":"22","author":"LMA de Lima","year":"1982","unstructured":"de Lima LMA, Berthier ME, Sad WE, DiNapoli J, Johnson CL, Marsh WL. Characterization of an anti-Dia antibody causing hemolytic disease in a newborn infant. Transfusion. 1982;22(3):246\u20137.","journal-title":"Transfusion"},{"issue":"5","key":"3516_CR12","first-page":"373","volume":"27","author":"SM Lee","year":"2007","unstructured":"Lee SM, Im SJ, Park SE, Lee EY, Kim HH. A case of severe hemolytic disease of the newborn due to anti-Dia antibody. Korean J Lab Med. 2007;27(5):373\u20136.","journal-title":"Korean J Lab Med"},{"issue":"9","key":"3516_CR13","first-page":"641","volume":"41","author":"M Monestier","year":"1984","unstructured":"Monestier M, Rigal D, Meyer F, Juron-Dupraz F, Baboin-Jaubert M, Marseglia GL. Hemolytic disease of newborn infants caused by anti-Diego antibodies. Arch Fr Pediatr. 1984;41(9):641\u20133.","journal-title":"Arch Fr Pediatr"},{"issue":"2","key":"3516_CR14","first-page":"323","volume":"39","author":"M Goto","year":"1987","unstructured":"Goto M, Sano T, Kubo H, Maeda Y, Maeda T. A case of hemolytic disease of the newborn due to anti-Dib antibody. Nihon Sanka Fujinka Gakkai Zasshi. 1987;39(2):323\u20136.","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"issue":"2","key":"3516_CR15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1182\/blood.V12.2.115.115","volume":"12","author":"M Layrisse","year":"1957","unstructured":"Layrisse M, Arends T. The Diego system; steps in the investigation of a new blood group system; further studies. Blood. 1957;12(2):115\u201322.","journal-title":"Blood"},{"issue":"2","key":"3516_CR16","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0188-4409(02)00469-1","volume":"34","author":"Z Hundric-Haspl","year":"2003","unstructured":"Hundric-Haspl Z, Balen-Marunic S, Tomasic-Susanj E, Tomicic M, Vujaklija-Stipanovic K. Anti-Diego a red blood cell alloantibody as a possible cause of anemia in a 3-week-old infant. Arch Med Res. 2003;34(2):149\u201351.","journal-title":"Arch Med Res"},{"issue":"2","key":"3516_CR17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.transci.2003.11.004","volume":"30","author":"F Komatsu","year":"2004","unstructured":"Komatsu F, Hasegawa K, Yanagisawa Y, Kawabata T, Kaneko Y, Watanabe S, Miyagi S, Sakuma M, Kagawa Y, Kajiwara M. Prevalence of Diego blood group Dia antigen in Mongolians: comparison with that in Japanese. Transfus Apher Sci. 2004;30(2):119\u201324.","journal-title":"Transfus Apher Sci"},{"issue":"5","key":"3516_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1080\/03014468400007291","volume":"11","author":"YD Yuan","year":"1984","unstructured":"Yuan YD, Du RF, Chen LZ, Xu JJ, Cui MY, Wang YF, Li SZ, Goedde HW, Benkmann HG, Kriese L, et\u00a0al. Distribution of eight blood-group systems and ABH secretion in Mongolian, Korean, and Zhuang nationalities in China. Ann Hum Biol. 1984;11(5):377\u201388.","journal-title":"Ann Hum Biol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03516-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-022-03516-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03516-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T23:17:58Z","timestamp":1657667878000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-022-03516-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,13]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3516"],"URL":"https:\/\/doi.org\/10.1186\/s13256-022-03516-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,13]]},"assertion":[{"value":"7 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"274"}}