{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:14:23Z","timestamp":1740147263297,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Alport syndrome is a rare inherited disorder affecting the glomerular basement membrane, manifested by hematuria and proteinuria that is commonly associated with ocular and hearing defects. There is limited information about the maternal and fetal outcomes of Alport syndrome in pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We describe a smooth course of pregnancy, a good maternal outcome, and a good fetal outcome in three consecutive pregnancies for a 35-year-old Mediterranean woman with Alport syndrome over a 10-year duration. Although there was a nephrotic range of progressive proteinuria in all her pregnancies, there was a prompt drop in proteinuria within 2\u00a0weeks of her deliveries. She has constantly shown a normal serum creatinine level and a normal serum protein level in all her pregnancies. Apart from a single episode of asymptomatic hypertension in her second pregnancy at 34\u00a0weeks of gestation that returned to a normal range immediately after delivery, she was normotensive antenatally and postnatally. She gave birth by cesarean section to three healthy newborns.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>A normal prepregnancy creatinine level and a mild range of proteinuria in a patient with normotension, who is not on any medication, are associated with good maternal and fetal outcomes. Furthermore, successful pregnancy that is followed by a normal renal function test might suggest a favorable outcome for any future pregnancy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-022-03565-7","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:04:04Z","timestamp":1661994244000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Good maternal and fetal outcomes of three consecutive pregnancies in a Mediterranean woman with Alport syndrome: a case report"],"prefix":"10.1186","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-7741","authenticated-orcid":false,"given":"Hasan","family":"Rawashdeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifaa A.","family":"Alchalabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf O.","family":"Oweis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haneen","family":"Al Jalodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"3565_CR1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00580116","author":"J Savige","year":"2016","unstructured":"Savige J, Colville D, Rheault M, Gear S, Lennon R, Lagas S, et\u00a0al. Special feature Alport syndrome in women and girls. Clin J Am Soc Nephrol. 2016. https:\/\/doi.org\/10.2215\/CJN.00580116.","journal-title":"Clin J Am Soc Nephrol"},{"key":"3565_CR2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200404000-00011","author":"CE Kashtan","year":"2004","unstructured":"Kashtan CE. Familial hematuria due to type IV collagen mutations: Alport syndrome and thin basement membrane nephropathy. Curr Opin Pediatr. 2004. https:\/\/doi.org\/10.1097\/00008480-200404000-00011.","journal-title":"Curr Opin Pediatr"},{"key":"3565_CR3","doi-asserted-by":"publisher","first-page":"11063","DOI":"10.3390\/ijms222011063","volume":"22","author":"R Mart\u00ednez-Pulleiro","year":"2021","unstructured":"Mart\u00ednez-Pulleiro R, Garc\u00eda-Murias M, Fidalgo-D\u00edaz M, Garc\u00eda-Gonz\u00e1lez M\u00c1. Molecular basis, diagnostic challenges and therapeutic approaches of Alport syndrome: a primer for clinicians. Int J Mol Sci. 2021;22:11063.","journal-title":"Int J Mol Sci"},{"key":"3565_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/01.AOG.0000240141.26395.82","volume":"109","author":"K Matsuo","year":"2007","unstructured":"Matsuo K, Tudor EL, Baschat AA. Alport syndrome and pregnancy. Obstet Gynecol. 2007;109:531\u20132.","journal-title":"Obstet Gynecol"},{"key":"3565_CR5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/jog.12897","volume":"42","author":"Y Nishizawa","year":"2016","unstructured":"Nishizawa Y, Takei T, Miyaoka T, Kamei D, Mochizuki T, Nitta K. Alport syndrome and pregnancy: Good obstetric and nephrological outcomes in a pregnant woman with homozygous autosomal recessive Alport syndrome. J Obstet Gynaecol Res. 2016;42:331\u20135.","journal-title":"J Obstet Gynaecol Res"},{"key":"3565_CR6","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s11255-012-0154-8","volume":"45","author":"F Crovetto","year":"2013","unstructured":"Crovetto F, Moroni G, Zaina B, Acaia B, Ossola MW, Fedele L. Pregnancy in women with Alport syndrome. Int Urol Nephrol. 2013;45:1223\u20137.","journal-title":"Int Urol Nephrol"},{"key":"3565_CR7","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s00404-015-3893-9","volume":"293","author":"E Yefet","year":"2016","unstructured":"Yefet E, Tovbin D, Nachum Z. Pregnancy outcomes in patients with Alport syndrome. Arch Gynecol Obstet. 2016;293:739\u201347.","journal-title":"Arch Gynecol Obstet"},{"key":"3565_CR8","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.xkme.2020.05.014","volume":"2","author":"BA Warady","year":"2020","unstructured":"Warady BA, Agarwal R, Bangalore S, Chapman A, Levin A, Stenvinkel P, et\u00a0al. Alport syndrome classification and management. Kidney Med. 2020;2:639\u201349.","journal-title":"Kidney Med"},{"key":"3565_CR9","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3109\/01443615.2013.834299","volume":"34","author":"M Alessi","year":"2014","unstructured":"Alessi M, Fabris A, Zambon A, Cremasco D, Muraro E, Dosa L, et\u00a0al. Pregnancy in Alport syndrome: a report of two differently-evolving cases. J Obstet Gynaecol (Lahore). 2014;34:98\u2013100.","journal-title":"J Obstet Gynaecol (Lahore)."},{"key":"3565_CR10","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s00404-018-4720-x","volume":"297","author":"F Brunini","year":"2018","unstructured":"Brunini F, Zaina B, Gianfreda D, Ossola W, Giani M, Fedele L, et\u00a0al. Alport syndrome and pregnancy: a case series and literature review. Arch Gynecol Obstet. 2018;297:1421\u201331. https:\/\/doi.org\/10.1007\/s00404-018-4720-x.","journal-title":"Arch Gynecol Obstet"},{"key":"3565_CR11","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00404-012-2225-6","volume":"286","author":"S Matsubara","year":"2012","unstructured":"Matsubara S, Muto S. Good obstetric outcome of consecutive pregnancies in a woman with Alport syndrome. Arch Gynecol Obstet. 2012;286:261\u20132.","journal-title":"Arch Gynecol Obstet"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03565-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-022-03565-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-022-03565-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:05:02Z","timestamp":1661994302000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-022-03565-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["3565"],"URL":"https:\/\/doi.org\/10.1186\/s13256-022-03565-7","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2022,9,1]]},"assertion":[{"value":"2 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approved.Consent for publicationWritten informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"328"}}