{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:14:31Z","timestamp":1740147271900,"version":"3.37.3"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Clostridium botulinum<\/jats:italic> is an anaerobic, Gram-positive, rod-shaped bacterium that forms spores and the neurotoxin botulinum. It is best known for its toxin-induced flaccid paralytic disease, which is deadly without correct treatment. In this report, we show a completely different clinical course with fatal outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 37-year-old African man born in Sierra Leone was admitted. After admission, his condition rapidly worsened due to severe septic shock and progressive multiorgan failure. No neurological signs were seen. Despite treatment with antibiotics, fluid resuscitation, and norepinephrine, the multiorgan failure deteriorated further and he died as a result. Blood and synovial fluid cultures showed <jats:italic>Clostridium botulinum<\/jats:italic>. No botulinum toxins were found.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This is a rare case of fatal septic shock due to <jats:italic>Clostridium botulinum<\/jats:italic>-induced septic arthritis without any sign of the classic clinical syndrome of botulism.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-023-04044-3","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:02:34Z","timestamp":1694091754000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Septic shock due to Clostridium botulinum: a case report"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9088-9592","authenticated-orcid":false,"given":"P. M. L.","family":"Zomer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J. A.","family":"Kamps","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"4044_CR1","unstructured":"Botulinum C, Tiwari A, Shivaraj Nagalli S. Last update November 25, 2021 https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553081\/. Accessed 04 Jun 2022"},{"issue":"8","key":"4044_CR2","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1086\/444507","volume":"41","author":"J Sobel","year":"2005","unstructured":"Sobel J. Botulism. Clin Infect Dis. 2005;41(8):1167\u201373. https:\/\/doi.org\/10.1086\/444507.","journal-title":"Clin Infect Dis"},{"key":"4044_CR3","unstructured":"Jeffery IA, Karim S. Botulism. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459273\/. Accessed 18 Jul 2022."},{"key":"4044_CR4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev.pharmtox.44.101802.121554","volume":"44","author":"LL Simpson","year":"2004","unstructured":"Simpson LL. Identification of the major steps in botulinum toxin action. Annu Rev Pharmacol Toxicol. 2004;44:167\u201393. https:\/\/doi.org\/10.1146\/annurev.pharmtox.44.101802.121554.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"8","key":"4044_CR5","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801\u201310. https:\/\/doi.org\/10.1001\/jama.2016.0287.","journal-title":"JAMA"},{"issue":"11","key":"4044_CR6","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","volume":"47","author":"E Laura","year":"2021","unstructured":"Laura E, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181\u2013247. https:\/\/doi.org\/10.1007\/s00134-021-06506-y.","journal-title":"Intensive Care Med"},{"key":"4044_CR7","doi-asserted-by":"publisher","unstructured":"The ARDS Definition Task Force*. Acute respiratory distress syndrome:\u00a0the berlin definition.\u00a0JAMA.\u00a02012;307(23):2526\u20132533. https:\/\/doi.org\/10.1001\/jama.2012.5669","DOI":"10.1001\/jama.2012.5669"},{"issue":"2","key":"4044_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr7002a1","volume":"70","author":"AK Rao","year":"2021","unstructured":"Rao AK, Sobel J, Chatham-Stephens K, Luquez C. Clinical guidelines for diagnosis and treatment of botulism, 2021. MMWR Recomm Rep. 2021;70(2):1\u201330. https:\/\/doi.org\/10.15585\/mmwr.rr7002a1.","journal-title":"MMWR Recomm Rep"},{"issue":"suppl 1","key":"4044_CR9","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1093\/cid\/cix811","volume":"66","author":"K Chatham-Stephens","year":"2017","unstructured":"Chatham-Stephens K, Fleck-Derderian S, Johnson SD, Sobel J, Rao AK, Meaney-Delman D. Clinical features of foodborne and wound botulism: a systematic review of the literature, 1932\u20132015. Clin Infect Dis. 2017;66(suppl 1):S11\u20136. https:\/\/doi.org\/10.1093\/cid\/cix811.","journal-title":"Clin Infect Dis"},{"issue":"6","key":"4044_CR10","first-page":"653","volume":"84","author":"DL Horowitz","year":"2011","unstructured":"Horowitz DL, Katzap E, Horowitz S, Barilla-LaBarca ML. Approach to septic arthritis. Am Fam Physician. 2011;84(6):653\u201360.","journal-title":"Am Fam Physician"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-023-04044-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-023-04044-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-023-04044-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T09:06:21Z","timestamp":1700471181000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-023-04044-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["4044"],"URL":"https:\/\/doi.org\/10.1186\/s13256-023-04044-3","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2023,9,7]]},"assertion":[{"value":"18 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research is conducted in a responsible and ethically accountable way, with no of harm to humans. This research may lead to beneficial outcomes in future similar cases.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"401"}}