{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:36:46Z","timestamp":1793507806642,"version":"4.5.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Crescentic glomerulonephritis with syphilis infection is rare, and the mechanism underlying the formation of glomerular capillary wall damage-induced crescent has not been elucidated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A\u00a062-year-old Japanese male showed edema, eruption, and rapid deterioration of the renal function after an acute syphilis infection. A renal biopsy showed crescentic glomerulonephritis with C3 deposition in the glomerular capillary wall, and immunostaining for anti-<jats:italic>Treponema pallidum<\/jats:italic> antibody was weakly positive in some interstitium and one glomerulus. Electron microscopy revealed the presence of string-shaped structures in the glomerular capillary walls. After treatment with penicillin followed by prednisolone, the renal function and urinary abnormalities, including <jats:italic>Treponema pallidum<\/jats:italic> protein, disappeared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Crescentic glomerulonephritis associated with syphilis showed a string-shaped deposition in the glomerular capillary and urinary <jats:italic>Treponema pallidum<\/jats:italic> protein excretion, and was effectively treated with penicillin and prednisolone.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-023-04293-2","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T01:02:22Z","timestamp":1703206942000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Crescentic glomerulonephritis associated with syphilis: a case report and review of the\u00a0literature"],"prefix":"10.1186","volume":"17","author":[{"given":"Akiko","family":"Kaiga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruna","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatemitsu","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9315-7546","authenticated-orcid":false,"given":"Akihiro","family":"Tojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"issue":"3","key":"4293_CR1","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1093\/oxfordjournals.ndt.a091852","volume":"4","author":"R Cahen","year":"1989","unstructured":"Cahen R, Francois B, Trolliet P, Gilly J, Parchoux B. Aetiology of membranous glomerulonephritis: a prospective study of 82 adult patients. Nephrol Dial Transplant. 1989;4(3):172\u201380.","journal-title":"Nephrol Dial Transplant"},{"issue":"9","key":"4293_CR2","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1056\/NEJM197502272920903","volume":"292","author":"CN Gamble","year":"1975","unstructured":"Gamble CN, Reardan JB. Immunopathogenesis of syphilitic glomerulonephritis. Elution of antitreponemal antibody from glomerular immune-complex deposits. N Engl J Med. 1975;292(9):449\u201354.","journal-title":"N Engl J Med."},{"issue":"3","key":"4293_CR3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1159\/000045792","volume":"86","author":"EM de Bustillo","year":"2000","unstructured":"de Bustillo EM, Rivera F, Trigueros M, Olivares J. Membranous nephropathy in a patient with syphilis and Hashimoto\u2019s disease. Nephron. 2000;86(3):344\u20135.","journal-title":"Nephron"},{"issue":"6","key":"4293_CR4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.nefro.2019.12.001","volume":"40","author":"K Kaynar","year":"2020","unstructured":"Kaynar K, Guvercin B, Mungan S, Ulusoy S. Don\u2019t forget syphilis in membranous nephropathy before immunosuppressants: latent syphilis in a patient with proteinuria. Nefrologia. 2020;40(6):681\u20132.","journal-title":"Nefrologia"},{"issue":"1","key":"4293_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12882-021-02404-z","volume":"22","author":"A Qi","year":"2021","unstructured":"Qi A, Fiset PO, Pilozzi-Edmonds L. Syphilis-related rapidly progressive glomerulonephritis: a case presentation. Bmc Nephrol. 2021;22(1):1.","journal-title":"Bmc Nephrol."},{"issue":"2","key":"4293_CR6","doi-asserted-by":"publisher","first-page":"106","DOI":"10.5414\/CN109847","volume":"93","author":"DK Nandikanti","year":"2020","unstructured":"Nandikanti DK, George LK, Walker PD, Kumar A, Wall BM. Resolution of syphilis-related rapidly progressive glomerulonephritis with penicillin therapy: case report. Clin Nephrol. 2020;93(2):106\u201310.","journal-title":"Clin Nephrol"},{"issue":"6","key":"4293_CR7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1001\/archinte.1946.00220060052003","volume":"78","author":"EW Thomas","year":"1946","unstructured":"Thomas EW, Schur M. Clinical nephropathies in early syphilis. Arch Intern Med (Chic). 1946;78(6):679\u201386.","journal-title":"Arch Intern Med (Chic)"},{"issue":"7","key":"4293_CR8","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1093\/ckj\/sfab057","volume":"14","author":"DC Wanderley","year":"2021","unstructured":"Wanderley DC, Neves P, Jorge LB, Onuchic LF, Araujo SA. The immunohistological profile of membranous nephropathy associated with syphilis infection. Clin Kidney J. 2021;14(7):1857\u20138.","journal-title":"Clin Kidney J"},{"issue":"3","key":"4293_CR9","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1681\/ASN.0000000000000061","volume":"34","author":"S Sethi","year":"2023","unstructured":"Sethi S, Madden B, Moura MC, Singh RD, Nasr SH, Hou J, et al. Membranous nephropathy in syphilis is associated with neuron-derived neurotrophic factor. J Am Soc Nephrol. 2023;34(3):374\u201384.","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"4293_CR10","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1128\/mr.57.3.750-779.1993","volume":"57","author":"SJ Norris","year":"1993","unstructured":"Norris SJ. Polypeptides of Treponema pallidum: progress toward understanding their structural, functional, and immunologic roles. Treponema Pallidum polypeptide research group. Microbiol Rev. 1993;57(3):750\u201379.","journal-title":"Microbiol Rev."},{"issue":"6","key":"4293_CR11","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/0002-9343(84)90866-0","volume":"76","author":"PD Walker","year":"1984","unstructured":"Walker PD, Deeves EC, Sahba G, Wallin JD, Oeill WM Jr. Rapidly progressive glomerulonephritis in a patient with syphilis. Identification of antitreponemal antibody and treponemal antigen in renal tissue. Am J Med. 1984;76(6):1106\u201312.","journal-title":"Am J Med."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-023-04293-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-023-04293-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-023-04293-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T01:02:29Z","timestamp":1703206949000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-023-04293-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["4293"],"URL":"https:\/\/doi.org\/10.1186\/s13256-023-04293-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]},"assertion":[{"value":"18 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The renal biopsy and sample analysis were performed with the approval of the clinical research ethics committee of Dokkyo Medical University (R-2-1, R-71-3J). NO patient-indicatable data were included in this case report. The patient thanked all the doctors and medical staff for their professional diagnosis and treatment of his disease without any adverse effects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"549"}}