{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:20:40Z","timestamp":1787685640248,"version":"build-2784847793"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Calcium channel blocker poisoning is one of the most lethal cardiac drugs overdoses. Calcium and high-dose insulin infusion are the first-line therapy for symptomatic patients, and Intralipid emulsion infusion is useful for refractory cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In this report, we describe a 17-year-old Iranian girl who took 250\u00a0mg of the drug for a suicidal attempt and presented with refractory hypotension and non-cardiogenic pulmonary edema treated successfully with the guidance of invasive hemodynamic parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>For complicated cases, in addition to supportive care and adjuvant therapy such as high-dose insulin and Intralipid, it is mandatory to utilize advanced hemodynamic monitoring to treat hypotension in severe calcium channel blocker poisoning to guide the treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04345-1","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T01:29:55Z","timestamp":1706923795000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Successful treatment of severe calcium channel blocker poisoning, new experience with the guidance of invasive hemodynamic monitoring in a 17-year-old girl: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Amir","family":"Saeed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7647-178X","authenticated-orcid":false,"given":"Amir","family":"Naghshzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,3]]},"reference":[{"key":"4345_CR1","doi-asserted-by":"publisher","first-page":"102292","DOI":"10.1016\/j.amsu.2021.102292","volume":"65","author":"S Matsushime","year":"2021","unstructured":"Matsushime S, Kuriyama A. Vasopressin for persistent hypotension due to amlodipine and olmesartan overdose: a case report. Ann Med Surg. 2021;65:102292. https:\/\/doi.org\/10.1016\/j.amsu.2021.102292.","journal-title":"Ann Med Surg"},{"issue":"4","key":"4345_CR2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.4037\/ccn2016524","volume":"36","author":"KE Reuter-Rice","year":"2016","unstructured":"Reuter-Rice KE, Peterson BM. Conventional and unconventional lifesaving therapies in an adolescent with amlodipine ingestion. Crit Care Nurse. 2016;36(4):64\u20139. https:\/\/doi.org\/10.4037\/ccn2016524.","journal-title":"Crit Care Nurse"},{"key":"4345_CR3","doi-asserted-by":"publisher","first-page":"bcr0320126114","DOI":"10.1136\/bcr.03.2012.6114","volume":"2012","author":"G Rosser","year":"2012","unstructured":"Rosser G, Dubrey SW. Massive calcium channel blocker overdose: intravenous insulin and glucose as a therapy. BMJ Case Rep. 2012;2012:bcr0320126114. https:\/\/doi.org\/10.1136\/bcr.03.2012.6114.","journal-title":"BMJ Case Rep"},{"key":"4345_CR4","doi-asserted-by":"publisher","first-page":"bcr2018225324","DOI":"10.1136\/bcr-2018-225324","volume":"2018","author":"F Fadhlillah","year":"2018","unstructured":"Fadhlillah F, Patil S. Pharmacological and mechanical management of calcium channel blocker toxicity. BMJ Case Rep. 2018;2018:bcr2018225324. https:\/\/doi.org\/10.1136\/bcr-2018-225324.","journal-title":"BMJ Case Rep"},{"key":"4345_CR5","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.12688\/f1000research.8991.1","volume":"5","author":"J Huygh","year":"2016","unstructured":"Huygh J, Peeters Y, Bernards J, Malbrain ML. Hemodynamic monitoring in the critically ill: an overview of current cardiac output monitoring methods. F1000Research. 2016;5:F1000. https:\/\/doi.org\/10.12688\/f1000research.8991.1.","journal-title":"F1000Research"},{"issue":"5","key":"4345_CR6","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1365-2044.2008.05835.x","volume":"64","author":"C Morris","year":"2009","unstructured":"Morris C, Perris A, Klein J, Mahoney P. Anaesthesia in hemodynamically compromised emergency patients: does ketamine represent the best choice of induction agent? Anaesthesia. 2009;64(5):532\u20139. https:\/\/doi.org\/10.1111\/j.1365-2044.2008.05835.x.","journal-title":"Anaesthesia"},{"issue":"3","key":"4345_CR7","doi-asserted-by":"publisher","first-page":"e306","DOI":"10.1097\/CCM.0000000000002087","volume":"45","author":"M St-Onge","year":"2017","unstructured":"St-Onge M, Anseeuw K, Cantrell FL, et\u00a0al. Experts consensus recommendations for the management of calcium channel blocker poisoning in adults. Crit Care Med. 2017;45(3):e306\u201315. https:\/\/doi.org\/10.1097\/CCM.0000000000002087.","journal-title":"Crit Care Med"},{"issue":"3","key":"4345_CR8","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/cc4938","volume":"10","author":"PE Lheureux","year":"2006","unstructured":"Lheureux PE, Zahir S, Gris M, Derrey AS, Penaloza A. Bench-to-bedside review: hyperinsulinemia\/euglycemia therapy in the management of an overdose of calcium-channel blockers. Crit Care. 2006;10(3):212. https:\/\/doi.org\/10.1186\/cc4938.","journal-title":"Crit Care"},{"issue":"1","key":"4345_CR9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1177\/1751143717705802","volume":"19","author":"E Walter","year":"2018","unstructured":"Walter E, McKinlay J, Corbett J, Kirk-Bayley J. Review of management in cardiotoxic overdose and efficacy of delayed intralipid use. J Intensive Care Soc. 2018;19(1):50\u20135. https:\/\/doi.org\/10.1177\/1751143717705802.","journal-title":"J Intensive Care Soc"},{"issue":"10","key":"4345_CR10","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1310\/hpj4810-848","volume":"48","author":"CJ Meaney","year":"2013","unstructured":"Meaney CJ, Sarah H, Hayes BD, Gonzales JP. Intravenous lipid emulsion in the management of amlodipine overdose. Hosp Pharm. 2013;48(10):848\u201354. https:\/\/doi.org\/10.1310\/hpj4810-848.","journal-title":"Hosp Pharm"},{"key":"4345_CR11","doi-asserted-by":"publisher","first-page":"546012","DOI":"10.1155\/2015\/546012","volume":"2015","author":"M Hedaiaty","year":"2015","unstructured":"Hedaiaty M, Eizadi-Mood N, Sabzghabaee AM. Noncardiogenic pulmonary edema after amlodipine overdose without refractory hypotension and bradycardia. Case Rep Emerg Med. 2015;2015:546012. https:\/\/doi.org\/10.1155\/2015\/546012.","journal-title":"Case Rep Emerg Med"},{"key":"4345_CR12","doi-asserted-by":"publisher","first-page":"927040","DOI":"10.1155\/2012\/927040","volume":"2012","author":"SK Shah","year":"2012","unstructured":"Shah SK, Goswami SK, Babu RV, Sharma G, Duarte AG. Management of calcium channel antagonist overdose with hyperinsulinemia-euglycemia therapy: case series and review of the literature. Case Rep Crit Care. 2012;2012:927040. https:\/\/doi.org\/10.1155\/2012\/927040.","journal-title":"Case Rep Crit Care"},{"issue":"11","key":"4345_CR13","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1080\/15563650.2020.1725034","volume":"58","author":"E Lindeman","year":"2020","unstructured":"Lindeman E, \u00c5lebring J, Johansson A, Ahlner J, Kugelberg FC, Nordmark GJ. The unknown known: non-cardiogenic pulmonary edema in amlodipine poisoning, a cohort study. Clin Toxicol. 2020;58(11):1042\u20139. https:\/\/doi.org\/10.1080\/15563650.2020.1725034.","journal-title":"Clin Toxicol"},{"issue":"4","key":"4345_CR14","doi-asserted-by":"publisher","first-page":"736.e5","DOI":"10.1016\/j.ajem.2018.01.038","volume":"36","author":"K Seegobin","year":"2018","unstructured":"Seegobin K, Maharaj S, Deosaran A, Reddy P. Severe beta-blocker and calcium channel blocker overdose: role of high dose insulin. Am J Emerg Med. 2018;36(4):736.e5-736.e6. https:\/\/doi.org\/10.1016\/j.ajem.2018.01.038.","journal-title":"Am J Emerg Med"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04345-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04345-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04345-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T01:31:01Z","timestamp":1706923861000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04345-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,3]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4345"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04345-1","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,3]]},"assertion":[{"value":"27 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethics committee of Shiraz University of Medical Sciences approved this study with approval ID: IR.sums.med.rec.1400.90. Written informed consent was obtained from the parents and sent to the ethics committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"68"}}