{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:12:57Z","timestamp":1762254777898},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>In this manuscript, we report a case of tacrolimus-associated hepatotoxicity in a kidney transplant recipient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In this case report, a 56\u00a0years old Arab male patient who received a kidney transplant presented with icterus, weakness, and lethargy two weeks after transplantation and tacrolimus initiation. In laboratory analysis hyperbilirubinemia and a rise in hepatic enzymes were observed. All possible causes of hepatotoxicity were examined. The panel for infectious causes was negative. Drug-induced liver injury was diagnosed. The patient\u2019s immunosuppressive regimen was changed to a cyclosporine-based regimen and after this change bilirubin and hepatic enzymes decreased and the patient was discharged without signs and symptoms of hepatitis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>It seems that the patient\u2019s hyperbilirubinemia was due to tacrolimus, and the patient\u2019s bilirubin decreased after stopping tacrolimus.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04394-6","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T15:02:49Z","timestamp":1708959769000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tacrolimus-induced cholestatic hepatotoxicity after renal transplantation: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Fatemeh","family":"Pourrezagholi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Amini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Ziaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"issue":"1","key":"4394_CR1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1097\/00007890-199807150-00013","volume":"66","author":"S Sanchez-Campos","year":"1998","unstructured":"Sanchez-Campos S, Lopez-Acebo R, Gonzalez P, Culebras JM, Tu\u00f1on MJ, Gonzalez-Gallego J. Cholestasis and alterations of glutathione metabolism induced by tacrolimus (FK506) in the rat. Transplantation. 1998;66(1):84\u20138.","journal-title":"Transplantation"},{"issue":"3","key":"4394_CR2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1272\/jnms.75.187","volume":"75","author":"N Taniai","year":"2008","unstructured":"Taniai N, Akimaru K, Ishikawa Y, Kanada T, Kakinuma D, Mizuguchi Y, Mamada Y, Yoshida H, Tajiri T. Hepatotoxicity caused by both tacrolimus and cyclosporine after living donor liver transplantation. J Nippon Med Sch. 2008;75(3):187\u201391.","journal-title":"J Nippon Med Sch"},{"issue":"3","key":"4394_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1056\/NEJMra1816149","volume":"381","author":"JH Hoofnagle","year":"2019","unstructured":"Hoofnagle JH, Bj\u00f6rnsson ES. Drug-induced liver injury\u2014types and phenotypes. N Engl J Med. 2019;381(3):264\u201373.","journal-title":"N Engl J Med"},{"issue":"2","key":"4394_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s13105-015-0451-7","volume":"72","author":"H Ferjani","year":"2016","unstructured":"Ferjani H, El Arem A, Bouraoui A, Achour A, Abid S, Bacha H, Boussema-Ayed I. Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats. J Physiol Biochem. 2016;72(2):133\u201344.","journal-title":"J Physiol Biochem"},{"issue":"8","key":"4394_CR5","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1093\/ndt\/gfg222","volume":"18","author":"A Vallet-Pichard","year":"2003","unstructured":"Vallet-Pichard A, Rerolle JP, Fontaine H, Larousserie F, Peraldi MN, Kreis H, Pol S. Veno-occlusive disease of the liver in renal transplant patients. Nephrol Dial Transplant. 2003;18(8):1663\u20136.","journal-title":"Nephrol Dial Transplant"},{"key":"4394_CR6","doi-asserted-by":"publisher","first-page":"1126765","DOI":"10.3389\/fphar.2023.1126765","volume":"14","author":"B Lv","year":"2023","unstructured":"Lv B, Liu L, Liu X, Huang M, Chen X, Tang K, Wang C, Chen P. Incidence, clinical features and risk factors of tacrolimus induced idiosyncratic liver injury in renal transplant recipients: a nested case-control study. Front Pharmacol. 2023;14:1126765.","journal-title":"Front Pharmacol"},{"issue":"5","key":"4394_CR7","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3109\/0886022X.2013.780621","volume":"35","author":"DK Yadav","year":"2013","unstructured":"Yadav DK, Gera DN, Gumber MR, Kute VB, Patel MP, Vanikar AV, Trivedi HL. Tacrolimus-induced severe cholestasis complicating renal transplantation. Ren Fail. 2013;35(5):735\u20137.","journal-title":"Ren Fail"},{"issue":"2","key":"4394_CR8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1399-3046.2005.00413.x","volume":"10","author":"R Ganschow","year":"2006","unstructured":"Ganschow R, Albani J, Grabhorn E, Richter A, Burdelski M. Tacrolimus-induced cholestatic syndrome following pediatric liver transplantation and steroid-resistant graft rejection. Pediatr Transplant. 2006;10(2):220\u20134.","journal-title":"Pediatr Transplant"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04394-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04394-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04394-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T15:06:20Z","timestamp":1708959980000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04394-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4394"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04394-6","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"assertion":[{"value":"1 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}},{"value":"The authors declared none.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"116"}}