{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:56:15Z","timestamp":1773255375359,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Rosai-Dorfman disease (RDD) is a form of non-Langerhans cell histiocytosis in which the activated histiocytes of the lymph nodes and other organs begin to accumulate following excessive production. Bilateral, massive, and painless lymphadenopathy are classic presentations. Systemic RDD is already known to be a rare condition, but isolated cutaneous RDD is extremely rare. We presented a rare and unusual presentations of a disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 35-year-old Thai female with a 6-month history of a small acne-like lesion that rapidly progressed to 5\u00a0cm tumor-like lesions on the face within 3\u00a0months. Tissue histology showed a dense dermal infiltration of histiocytes with emperipolesis phenomenon. Immunohistochemistry was positive for S100 protein and CD68 and negative for CD1a. Oral prednisolone (50\u00a0mg\/day) was initiated with a favorable outcome at the one-month follow-up. However, prednisolone yielded a partial response at 2-month follow-up, leading to application of another modality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Although cutaneous Rosai-Dorfman disease is considered benign and well medical responded disease, patients with atypical presentation and rapid growing lesion may necessitate aggressive multimodal treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04410-9","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T01:24:59Z","timestamp":1711502699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Facial cutaneous Rosai-Dorfman disease: a\u00a0case report"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9005-6936","authenticated-orcid":false,"given":"Tanapong","family":"Wongrat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siripan","family":"Sangmala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"issue":"26","key":"4410_CR1","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1182\/blood-2018-03-839753","volume":"131","author":"O Abla","year":"2018","unstructured":"Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile J-F, et al. Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood. 2018;131(26):2877\u201390. https:\/\/doi.org\/10.1182\/blood-2018-03-839753.","journal-title":"Blood"},{"issue":"2","key":"4410_CR2","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3324\/haematol.2019.219626","volume":"105","author":"G Goyal","year":"2019","unstructured":"Goyal G, Ravindran A, Young JR, Shah MV, Bennani NN, Patnaik MM, et al. Clinicopathological features, treatment approaches, and outcomes in Rosai-Dorfman disease. Haematologica. 2019;105(2):348\u201357. https:\/\/doi.org\/10.3324\/haematol.2019.219626.","journal-title":"Haematologica"},{"issue":"4","key":"4410_CR3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/dad.0b013e31829e5564","volume":"36","author":"Z Kutlubay","year":"2014","unstructured":"Kutlubay Z, Bairamov O, Sevim A, Demirkesen C, Mat MC. Rosai-Dorfman disease. Am J Dermatopathol. 2014;36(4):353\u20137. https:\/\/doi.org\/10.1097\/dad.0b013e31829e5564.","journal-title":"Am J Dermatopathol"},{"issue":"22","key":"4410_CR4","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","volume":"127","author":"J-F Emile","year":"2016","unstructured":"Emile J-F, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127(22):2672\u201381. https:\/\/doi.org\/10.1182\/blood-2016-01-690636.","journal-title":"Blood"},{"issue":"1","key":"4410_CR5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1159\/000324760","volume":"4","author":"MJ Molina-Garrido","year":"2011","unstructured":"Molina-Garrido MJ, Guill\u00e9n-Ponce C. Extranodal Rosai-Dorfman disease with cutaneous and periodontal involvement: a rare presentation. Case Rep Oncol. 2011;4(1):96\u2013100. https:\/\/doi.org\/10.1159\/000324760.","journal-title":"Case Rep Oncol"},{"issue":"10","key":"4410_CR6","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00256-005-0906-y","volume":"34","author":"PM Young","year":"2005","unstructured":"Young PM, Kransdorf MJ, Temple HT, Mousavi F, Robinson PG. Rosai-Dorfman disease presenting as multiple soft tissue masses. Skelet Radiol. 2005;34(10):665\u20139. https:\/\/doi.org\/10.1007\/s00256-005-0906-y.","journal-title":"Skelet Radiol"},{"issue":"3","key":"4410_CR7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/01.pas.0000213387.70783.b6","volume":"31","author":"Y Kong","year":"2007","unstructured":"Kong Y, Kong J, Shi D, Lu H, Zhu X, Wang J, et al. Cutaneous rosai-dorfman disease. Am J Surg Pathol. 2007;31(3):341\u201350. https:\/\/doi.org\/10.1097\/01.pas.0000213387.70783.b6.","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"4410_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/bf01626356","volume":"419","author":"F Delacr\u00e9taz","year":"1991","unstructured":"Delacr\u00e9taz F, Meug\u00e9-Moraw C, Anwar D, Borisch B, Chave J-P. Sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman disease) in an HIV-positive patient. Virchows Archiv A Pathol Anat Histopathol. 1991;419(3):251\u20134. https:\/\/doi.org\/10.1007\/bf01626356.","journal-title":"Virchows Archiv A Pathol Anat Histopathol"},{"issue":"5","key":"4410_CR9","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3390\/biology10050396","volume":"10","author":"K-J Wu","year":"2021","unstructured":"Wu K-J, Li S-H, Liao J-B, Chiou C-C, Wu C-S, Chen C-C. NRAS mutations may be involved in the pathogenesis of cutaneous Rosai Dorfman disease: a pilot study. Biology. 2021;10(5):396. https:\/\/doi.org\/10.3390\/biology10050396.","journal-title":"Biology"},{"issue":"5","key":"4410_CR10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/00000372-200210000-00001","volume":"24","author":"T Brenn","year":"2002","unstructured":"Brenn T, Calonje E, Granter SR, Leonard N, Grayson W, Fletcher CD, et al. Cutaneous rosai-dorfman disease is a distinct clinical entity. Am J Dermatopathol. 2002;24(5):385\u201391. https:\/\/doi.org\/10.1097\/00000372-200210000-00001.","journal-title":"Am J Dermatopathol"},{"issue":"11","key":"4410_CR11","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1136\/jclinpath-2020-206733","volume":"73","author":"C Bruce-Brand","year":"2020","unstructured":"Bruce-Brand C, Schneider JW, Schubert P. Rosai-Dorfman disease: an overview. J Clin Pathol. 2020;73(11):697\u2013705. https:\/\/doi.org\/10.1136\/jclinpath-2020-206733.","journal-title":"J Clin Pathol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04410-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04410-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04410-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T01:25:29Z","timestamp":1711502729000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04410-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4410"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04410-9","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]},"assertion":[{"value":"25 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"182"}}