{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:14:42Z","timestamp":1740147282212,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>IgG4-related disease (IgG4RD) is a rare fibroinflammatory disease with multiorgan involvement. It presents insidiously over several years and can be a diagnostic enigma. Delays in diagnosis occur due to failure to consider IgG4 as a differential diagnosis, atypical presentations, and an insidious clinical course.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report the case of a 70-year-old Sri Lankan man with pulmonary, renal, and neurological involvement of IgG4-related disease. Clinical manifestations evolved over a 4-year period and included exertional shortness of breath and dysesthesia of extremities. The diagnosis was established with clinical, radiological, and pathological criteria laid down by The American College of Rheumatology\/European League Against Rheumatism in 2019.<\/jats:p>\n                <jats:p>Following diagnosis, the patient was started on oral steroids, with rapid improvement of his respiratory and neurological symptoms. He is currently under follow-up and will be monitored with clinical and radiological parameters, complement levels, and lung function tests.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This case outlines the presentation of a patient with IgG4-related disease with concurrent involvement of three uncommon sites. It highlights methods of diagnostic deduction by considering the clinical course of illness, imaging, and histopathology. It also describes evolving associations of IgG4-related disease with tuberculosis and lymphomas, which bear important diagnostic and therapeutic considerations.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04418-1","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T01:02:03Z","timestamp":1709082123000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IgG4 disease with multiorgan involvement: a case report"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-1238","authenticated-orcid":false,"given":"M. N.","family":"Vidanapathirana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wijayaratne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"issue":"8","key":"4418_CR1","doi-asserted-by":"publisher","first-page":"635706","DOI":"10.3389\/fmed.2021.635706","volume":"31","author":"R Capecchi","year":"2021","unstructured":"Capecchi R, Giannese D, Moriconi D, Bonadio AG, Pratesi F, Croia C, Egidi MF, Puxeddu I, Tavoni AG, Migliorini P. Renal involvement in IgG4-related disease: from sunlight to twilight. Front Med. 2021;31(8):635706. https:\/\/doi.org\/10.3389\/fmed.2021.635706.","journal-title":"Front Med"},{"key":"4418_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216561","author":"ZS Wallace","year":"2019","unstructured":"Wallace ZS, et\u00a0al. The 2019 American College of Rheumatology\/European league against rheumatism classification criteria for IgG4-related disease. Ann Rheum Dis. 2019. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216561.","journal-title":"Ann Rheum Dis"},{"key":"4418_CR3","volume-title":"IgG4 related disease","author":"S Nambiar","year":"2022","unstructured":"Nambiar S, Oliver TI. IgG4 related disease. Treasure Island: StatPearls Publishing; 2022."},{"issue":"4","key":"4418_CR4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s11940-017-0450-9","volume":"19","author":"B Baptista","year":"2017","unstructured":"Baptista B, Casian A, Gunawardena H, D\u2019Cruz D, Rice CM. Neurological manifestations of IgG4-related disease. Curr Treat Options Neurol. 2017;19(4):14. https:\/\/doi.org\/10.1007\/s11940-017-0450-9.","journal-title":"Curr Treat Options Neurol"},{"key":"4418_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.652985\/full","author":"P Qing","year":"2021","unstructured":"Qing P, et\u00a0al. IgG4-related disease with tuberculosis: a case report and retrospective review of patients in a single center. Front Immunol. 2021. https:\/\/doi.org\/10.3389\/fimmu.2021.652985\/full.","journal-title":"Front Immunol"},{"issue":"3","key":"4418_CR6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-237466","volume":"14","author":"N Hornstein","year":"2021","unstructured":"Hornstein N, Razmjou A, Weinreb A, El-Masry M. Mimic of malignancy: delineating IgG4-related disease and lymphoma. BMJ Case Rep. 2021;14(3): e237466. https:\/\/doi.org\/10.1136\/bcr-2020-237466.","journal-title":"BMJ Case Rep"},{"issue":"5","key":"4418_CR7","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s00428-017-2286-9","volume":"472","author":"JR Bledsoe","year":"2018","unstructured":"Bledsoe JR, Wallace ZS, Stone JH, Deshpande V, Ferry JA. Lymphomas in IgG4-related disease: clinicopathologic features in a Western population. Virchows Arch. 2018;472(5):839\u201352. https:\/\/doi.org\/10.1007\/s00428-017-2286-9.","journal-title":"Virchows Arch"},{"issue":"49","key":"4418_CR8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009140","volume":"96","author":"CF Chen","year":"2017","unstructured":"Chen CF, Chu KA, Tseng YC, Wu CC, Lai RS. IgG4-related lung disease presenting as interstitial lung disease with bronchiolitis: a case report. Medicine. 2017;96(49): e9140. https:\/\/doi.org\/10.1097\/MD.0000000000009140.","journal-title":"Medicine"},{"key":"4418_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12931-020-01542-6","volume":"21","author":"J Kang","year":"2020","unstructured":"Kang J, Park S, Chae EJ, et\u00a0al. Long-term clinical course and outcomes of immunoglobulin G4-related lung disease. Respir Res. 2020;21:273. https:\/\/doi.org\/10.1186\/s12931-020-01542-6.","journal-title":"Respir Res"},{"issue":"4","key":"4418_CR10","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1001\/jamaneurol.2013.658","volume":"70","author":"K Ohyama","year":"2013","unstructured":"Ohyama K, Koike H, Iijima M, et\u00a0al. IgG4-related neuropathy: a case report. JAMA Neurol. 2013;70(4):502\u20135.","journal-title":"JAMA Neurol"},{"key":"4418_CR11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12883-021-02069-z","volume":"21","author":"JB Bong","year":"2021","unstructured":"Bong JB, Lee DK, Lee MA, et\u00a0al. Immunoglobulin G4-related disease presenting with peripheral neuropathy: a case report. BMC Neurol. 2021;21:41. https:\/\/doi.org\/10.1186\/s12883-021-02069-z.","journal-title":"BMC Neurol"},{"issue":"5","key":"4418_CR12","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.3348\/kjr.2015.16.5.1056","volume":"16","author":"N Seo","year":"2015","unstructured":"Seo N, Kim JH, Byun JH, Lee SS, Kim HJ, Lee MG. Immunoglobulin G4-related kidney disease: a comprehensive pictorial review of the imaging spectrum, mimickers, and clinicopathological characteristics. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"115"}}