{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:15:12Z","timestamp":1740147312202,"version":"3.37.3"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Scleredema adultorum of Buschke is a rare disease characterized by firm and non-pitting edema of the skin. The condition is rare with unknown etiology. Diagnosis is made on the basis of clinical findings and skin biopsy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Here, we describe a 14-year-old Iranian girl presenting with non-pitting edema and woody thickening of the skin that progressed within a month. She was evaluated for possible underlying malignancy or connective tissue disorders, which were excluded by multiple laboratory workups. She underwent a skin biopsy which confirmed the diagnosis of scleredema, and she was successfully treated with intravenous immunoglobulin and mycophenolate mofetil.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>While scleredema adultorum of Buschke is a rare disease with no definite treatment, our effort through this report was to highlight the possible benefits of treatment by intravenous immunoglobulin and mycophenolate mofetil.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04427-0","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T01:02:21Z","timestamp":1707872541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Mehran","family":"Pournazari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dena","family":"Mohamadzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-492X","authenticated-orcid":false,"given":"Shirin","family":"Assar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazaher","family":"Ramezani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"issue":"1","key":"4427_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0190-9622(84)70146-0","volume":"11","author":"PY Venencie","year":"1984","unstructured":"Venencie PY, Powell FC, Su WD, Perry HO. Scleredema: a review of thirty-three cases. J Am Acad Dermatol. 1984;11(1):128\u201334.","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"4427_CR2","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1111\/jdv.13272","volume":"29","author":"F Rongioletti","year":"2015","unstructured":"Rongioletti F, Kaiser F, Cinotti E, Metze D, Battistella M, Calzavara-Pinton P, et al. A multicentre study of characteristics, comorbidities, course and therapy in 44 patients. J Eur Acad Dermatol Venereol. 2015;29(12):2399\u2013404.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"4427_CR3","doi-asserted-by":"crossref","unstructured":"Beers WH, Ince A, Moore TL, editors. Scleredema adultorum of Buschke: a case report and review of the literature. 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JAAD Case Rep. 2020;6(10):1039\u201341.","journal-title":"JAAD Case Rep"},{"issue":"2","key":"4427_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jdds.2014.03.003","volume":"19","author":"O Ezejiofor","year":"2015","unstructured":"Ezejiofor O, Onayemi O, Olasode O, Ikem R, Komolafe A, Ezejiofor I. Scleredema diabeticorum\u2014a case report. J Dermatol Dermatol Surg. 2015;19(2):146\u20139.","journal-title":"J Dermatol Dermatol Surg"},{"issue":"19","key":"4427_CR7","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"A Gabrielli","year":"2009","unstructured":"Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med. 2009;360(19):1989\u20132003.","journal-title":"N Engl J Med"},{"issue":"2","key":"4427_CR8","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S0190-9622(98)70244-0","volume":"38","author":"CM Hager","year":"1998","unstructured":"Hager CM, Sobhi HA, Hunzelmann N, Wickenhauser C, Scharenberg R, Krieg T, et al. Bath-PUVA therapy in three patients with scleredema adultorum. J Am Acad Dermatol. 1998;38(2):240\u20132.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"4427_CR9","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.jemermed.2003.12.006","volume":"26","author":"S Kurto\u011flu","year":"2004","unstructured":"Kurto\u011flu S, Y\u00fcksel \u015e, G\u00fcnd\u00fcz Z, Per H, Narin N, Konta\u015f O, et al. Use of high-dose intravenous corticosteroid treatment in a child with scleredema. J Emerg Med. 2004;26(2):245\u20136.","journal-title":"J Emerg Med"},{"issue":"1","key":"4427_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.adro.2015.11.002","volume":"1","author":"T Skrepnik","year":"2016","unstructured":"Skrepnik T, Gottesman S, Stea B. Long-term benefit of electron beam radiation therapy in the treatment of scleredema of Buschke. Adv Radiat Oncol. 2016;1(1):21\u20135.","journal-title":"Adv Radiat Oncol"},{"key":"4427_CR11","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/S0190-9622(96)90129-2","volume":"35","author":"G Mattheou-Vakali","year":"1996","unstructured":"Mattheou-Vakali G. Cyclosporine in scleredema. J Am Acad Dermatol. 1996;35:990\u20131.","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"4427_CR12","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2340\/00015555-2846","volume":"98","author":"D Miguel","year":"2018","unstructured":"Miguel D, Schliemann S, Elsner P. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"93"}}