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Sarcoidosis often poses a diagnostic challenge owing to its nonspecific or mild clinical features. In 20\u201335% of cases, sarcoidosis initially presents on skin. However, skin lesions commonly mimic dermatological conditions. Therefore, it is important to not underestimate the skin manifestations and perform histopathological examinations to make a timely diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present two cases of 33-year-old Caucasian female patients with orange\u2013red macules and plaques that developed in the eyebrow area 1 and 6\u00a0years after microblading, respectively. Histopathological examination confirmed a diagnosis of sarcoidosis. The lymph nodes and lungs were also affected in both patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our two reports suggest that an esthetic procedure involving dermal or subcutaneous injection of foreign materials can trigger the development of cutaneous and systemic sarcoidosis. However, this relationship has not been described yet. Physicians should, therefore, be aware of this complication to properly evaluate and treat such patients in a timely manner.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04439-w","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:01:28Z","timestamp":1713916888000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Microblading reaction as a manifestation of systemic sarcoidosis: two case\u00a0reports and\u00a0a\u00a0review of the literature"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-1868","authenticated-orcid":false,"given":"Eva Klara","family":"Merzel \u0160abovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateja","family":"Starbek Zorko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Hosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borut","family":"\u017dgavec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vid","family":"Bajuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"4439_CR1","doi-asserted-by":"publisher","first-page":"00155","DOI":"10.1183\/23120541.00155-2020","volume":"6","author":"A Malkova","year":"2020","unstructured":"Malkova A, Starshinova A, Zinchenko Y, Basantsova N, Mayevskaya V, Yablonskiy P, Shoenfeld Y. 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