{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:25:27Z","timestamp":1772720727155,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Gastrosplenic fistula is a rare and potentially fatal complication of various conditions. Lymphoma is the most common cause. It can occur spontaneously or after chemotherapy. Gastrosplenic fistula diagnosis can be confused with a splenic abscess because of the presence of air into the mass. The computed tomography identification of the fistulous tract is the key to a right diagnosis. Treatment modalities include surgical resection, chemotherapy, or a combination of both.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Here we report two patients with gastrosplenic fistula due to diffuse large B cell lymphoma. The first patient was a 54-year-old Caucasian woman with an enormous primary splenic diffuse large B cell lymphoma leading to the development of a spontaneous fistula in the stomach. The second patient was a 48-year-old Caucasian male patient with an enormous splenic diffuse large B cell lymphoma complicated by fistula after chemotherapy. Both patients died of septic shock several days after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Gastrosplenic fistula is a rare complication with a poor-prognosis, for which surgery is currently the preferred treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04441-2","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T01:04:58Z","timestamp":1709773498000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gastrosplenic fistula due to splenic lymphoma: two case reports and review of the\u00a0literature"],"prefix":"10.1186","volume":"18","author":[{"given":"Feryel Letaief","family":"Ksontini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosra","family":"Zaimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaad","family":"Nefzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Khrouf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-8248","authenticated-orcid":false,"given":"Myriam","family":"Ayari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Sghaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Zidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houcine","family":"Magherbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouna","family":"Ayadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"issue":"8","key":"4441_CR1","first-page":"805","volume":"17","author":"YL Ding","year":"2012","unstructured":"Ding YL, Wang SY. Gastrosplenic fistula due to splenic large B-cell lymphoma. J Res Med Sci. 2012;17(8):805\u20137.","journal-title":"J Res Med Sci"},{"key":"4441_CR2","doi-asserted-by":"publisher","first-page":"S1513","DOI":"10.14309\/00000434-201810001-02713","volume":"113","author":"A Kapoor","year":"2018","unstructured":"Kapoor A, Nanavati S, Kumar V, Azam S, Komal F, Singhal M. Aerosplenomegaly: case of gastrosplenic fistula and splenic abscess in lymphom. Am J Gastroenterol. 2018;113:S1513.","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"4441_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S1015-9584(09)60104-4","volume":"29","author":"M Kerem","year":"2006","unstructured":"Kerem M, Sakrak O, Yilmaz TU, Gultekin FA, Dursun A, Bedirli A. Spontaneous gastrosplenic fistula in primary gastric lymphoma: surgical management. Asian J Surg. 2006;29(4):287\u201390.","journal-title":"Asian J Surg"},{"issue":"35","key":"4441_CR4","doi-asserted-by":"publisher","first-page":"6491","DOI":"10.3748\/wjg.v23.i35.6491","volume":"23","author":"DH Kang","year":"2017","unstructured":"Kang DH, Huh J, Lee JH, Jeong YK, Cha HJ. Gastrosplenic fistula occurring in lymphoma patients: systematic review with a new case of extranodal NK\/T-cell lymphoma. World J Gastroenterol. 2017;23(35):6491\u20139.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"4441_CR5","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1007\/s00261-002-0011-9","volume":"27","author":"JE Choi","year":"2002","unstructured":"Choi JE, Chung HJ, Lee HG. Spontaneous gastrosplenic fistula: a rare complication of splenic diffuse large cell lymphoma. Abdom Imaging. 2002;27(6):728\u201330.","journal-title":"Abdom Imaging"},{"key":"4441_CR6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.04.2010.2932","author":"F Khan","year":"2010","unstructured":"Khan F, Vessal S, McKimm E, D\u2019Souza R. Spontaneous gastrosplenic fistula secondary to primary splenic lymphoma. BMJ Case Rep. 2010. https:\/\/doi.org\/10.1136\/bcr.04.2010.2932.","journal-title":"BMJ Case Rep"},{"key":"4441_CR7","first-page":"64","volume":"3","author":"KM Moghazy","year":"2008","unstructured":"Moghazy KM. Gastrosplenic fistula following chemotherapy for lymphoma. Gulf J Oncolog. 2008;3:64\u20137.","journal-title":"Gulf J Oncolog"},{"issue":"11","key":"4441_CR8","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1097\/RLU.0000000000001801","volume":"42","author":"TP Wang","year":"2017","unstructured":"Wang TP, Doss M, Tokar JL, Reddy S, Barta SK, Yu JQ. Lymphoma causing gastrosplenic fistula revealed by FDG PET\/CT. Clin Nucl Med. 2017;42(11):890\u20132.","journal-title":"Clin Nucl Med"},{"issue":"11","key":"4441_CR9","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1002\/1097-0142(19841201)54:11<2460::AID-CNCR2820541125>3.0.CO;2-K","volume":"54","author":"NL Harris","year":"1984","unstructured":"Harris NL, Aisenberg AC, Meyer JE, Ellman L, Elman A. Diffuse large cell (histiocytic) lymphoma of the spleen. Clinical and pathologic characteristics of ten cases. Cancer. 1984;54(11):2460\u20137.","journal-title":"Cancer"},{"issue":"3","key":"4441_CR10","first-page":"270","volume":"95","author":"LD Rothermel","year":"2010","unstructured":"Rothermel LD, Chadwick CL, Thambi-Pillai T. Gastrosplenic fistula: etiologies, diagnostic studies, and surgical management. Int Surg. 2010;95(3):270\u20132.","journal-title":"Int Surg"},{"issue":"2","key":"4441_CR11","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1159\/000500505","volume":"12","author":"M Saito","year":"2019","unstructured":"Saito M, Miyashita K, Miura Y, Harada S, Ogasawara R, Izumiyama K, et\u00a0al. Successful treatment of gastrosplenic fistula arising from diffuse large B-cell lymphoma with chemotherapy: two case reports. Case Rep Oncol. 2019;12(2):376\u201383.","journal-title":"Case Rep Oncol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04441-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04441-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04441-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T01:05:21Z","timestamp":1709773521000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04441-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4441"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04441-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]},"assertion":[{"value":"28 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Consent to participate was waived due to retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patients for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"136"}}