{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:19:00Z","timestamp":1758637140298},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Breast metastasis from primary ovarian cancer is rare, with an estimated frequency of 0.07%. More than 110 cases are reported in the literature of metastatic spread of ovarian cancer to the breast and axilla. This entity usually represents aggressive late disease characterized by multi-drug chemoresistance and a poor prognosis with a median survival time of 16\u00a0months. Currently no standardized treatment protocol exists for this condition.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a case of a 59-year-old Caucasian female with recurrent high-grade serous ovarian cancer who was diagnosed with symptomatic unilateral breast metastasis while on fourth line chemotherapy with weekly paclitaxel. She was treated with local radiation with 2300\u00a0cGy to the right breast with a complete response. She then had a subsequent recurrence in the ipsilateral breast 8\u00a0months after completion of post treatment imaging. She remains alive to date approximately 2\u00a0years after her initial diagnosis of breast metastasis on seventh line treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Breast metastasis from primary ovarian cancer is rare and represents advanced disease characterized by multi-drug chemoresistance and a poor prognosis. This case describes radiation therapy as a safe, effective treatment option to improve local control and quality of life in these patients, but with limited durability of response.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04445-y","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T01:01:42Z","timestamp":1711414902000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metastasis of serous ovarian carcinoma to the breast: a case report and review of the literature"],"prefix":"10.1186","volume":"18","author":[{"given":"Sofia","family":"Due\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsin","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Hew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"4445_CR1","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1097\/00000478-200412000-00015","volume":"28","author":"MA Recine","year":"2004","unstructured":"Recine MA. Serous carcinoma of the ovary and peritoneum with metastases to the breast and axillary lymph nodes. Am J Surg Pathol. 2004;28:1646\u201351.","journal-title":"Am J Surg Pathol."},{"issue":"1","key":"4445_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.7150\/jca.1.27","volume":"2","author":"RL Klein","year":"2010","unstructured":"Klein RL, Brown AR, Gomez-Castro CM, Chambers SK, Cragun JM, Grasso-Lebeau L, et al. Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: a case report and literature review. J Cancer. 2010;2(1):27\u201331.","journal-title":"J Cancer"},{"issue":"8","key":"4445_CR3","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3390\/cancers11081044","volume":"11","author":"N Thomakos","year":"2019","unstructured":"Thomakos N, Diakosavvas M, Machairiotis N, Fasoulakis Z, Zarogoulidis P, Rodolakis A. Rare distant metastatic disease of ovarian and peritoneal carcinomatosis: a review of the literature. Cancers (Basel). 2019;11(8):1044.","journal-title":"Cancers (Basel)"},{"issue":"8","key":"4445_CR4","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1136\/ijgc-2022-003498","volume":"32","author":"L Chiva","year":"2022","unstructured":"Chiva L, Marquez R, Castellanos T. Breast metastases from a serous ovarian carcinoma. Int J Gynecol Cancer. 2022;32(8):1086.","journal-title":"Int J Gynecol Cancer"},{"issue":"11","key":"4445_CR5","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2022-251721","volume":"15","author":"A Musa","year":"2022","unstructured":"Musa A, Joiner M, Dzul S, Miller SR. Metastatic spread of serous ovarian carcinoma to the bilateral breasts: a rare presentation. BMJ Case Rep. 2022;15(11): e251721.","journal-title":"BMJ Case Rep"},{"key":"4445_CR6","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13256-020-02653-w","volume":"15","author":"Y Maeshima","year":"2021","unstructured":"Maeshima Y, Osako T, Morizono H, Yunokawa M, Miyagi Y, Kikuchi M, et al. Metastatic ovarian cancer spreading into mammary ducts mimicking an in situ component of primary breast cancer: a case report. J Med Case Rep. 2021;15:78.","journal-title":"J Med Case Rep"},{"issue":"3","key":"4445_CR7","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1159\/000509770","volume":"13","author":"G Caruso","year":"2020","unstructured":"Caruso G, Musacchio L, Santangelo G, Palaia I, Tomao F, Di Donato V, et al. Ovarian cancer metastasis to the breast: a case report and review of the literature. Case Rep Oncol. 2020;13(3):1317\u201324.","journal-title":"Case Rep Oncol"},{"key":"4445_CR8","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1159\/000508358","volume":"13","author":"M Abu-Tineh","year":"2020","unstructured":"Abu-Tineh M, Elmalik H, Yassin M. Metastatic ovarian cancer presenting as inflammatory breast cancer: a case report. Case Rep Oncol. 2020;13:867\u201374.","journal-title":"Case Rep Oncol"},{"issue":"12","key":"4445_CR9","doi-asserted-by":"publisher","first-page":"13015","DOI":"10.2147\/CMAR.S280795","volume":"18","author":"J Wang","year":"2020","unstructured":"Wang J, Wang B. Metastasis of ovarian cancer to breast: a case report and review of imaging manifestations. Cancer Manag Res. 2020;18(12):13015\u201321.","journal-title":"Cancer Manag Res"},{"issue":"6","key":"4445_CR10","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1016\/j.radcr.2018.08.008","volume":"13","author":"L Antuono","year":"2018","unstructured":"Antuono L, Angela F, Luca N, Giovanni M, Enrico C. Breast metastasis from ovarian cancer: a case report. Radiol Case Rep. 2018;13(6):1166\u20139.","journal-title":"Radiol Case Rep"},{"issue":"6","key":"4445_CR11","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.3892\/ol.2016.4514","volume":"11","author":"CB Tempfer","year":"2016","unstructured":"Tempfer CB, el Fizazi N, Ergonenc H, Solass W. Metastasis of ovarian cancer to the breast: a report of two cases and a review of the literature. 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A copy of the written consent is available by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"127"}}