{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:46:04Z","timestamp":1793299564980,"version":"4.5.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Brain abscesses are rare but potentially fatal condition and can be associated with cyanotic congenital heart disease of which 5\u201318.7% of these patients that develop cerebral abscess commonly have tetralogy of Fallot (TOF).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a case of 3-year-old Muganda male that presented with convulsions, cyanosis and difficulty in breathing. The patient had a combination intervention of medical treatment and surgical drainage of the abscess. Post-operative Computerized tomography scan images and pre-operative brain Computerized tomography scans were compared. The multiple rings enhancing lesions were reduced in number and sizes. The largest measured ring was 44\u2009\u00d7\u200922.5\u00d716mm compared to the previous; 42\u2009\u00d7\u200941\u00d736mm. The mass effect had reduced from 16\u00a0mm to 7.5\u00a0mm. The periventricular hypodensities persisted. Findings showed radiological improvement with residual abscesses, subacute subdural hematoma and pneumocranium. The patient was treated with intravenous ceftriaxone 1\u00a0g OD for six weeks and he showed marked improvement and was discharged home after 3\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A comprehensive strategy involving medications, surgical drainage, and early neurosurgical consultation is vital in treating brain abscesses in uncorrected TOF. Early identification of the pathogen, appropriate antibiotic therapy, and vigilant follow-up through clinical assessments and imaging are crucial, potentially spanning a 4\u20138-week treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04451-0","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T01:30:42Z","timestamp":1711589442000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tetralogy of Fallot complicated by multiple cerebral abscesses in a child: a case report"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-5617","authenticated-orcid":false,"given":"Larrey Kasereka","family":"Kamabu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck Katembo","family":"Sikakulya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louange Maha","family":"Kataka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bives Nzanzu Mutume","family":"Vivalya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9 Monka","family":"Lekuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doomwin Oscar Deogratius","family":"Obiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet Nalwanga","family":"Sekabunga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey S.","family":"Bbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"issue":"1","key":"4451_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3329\/bhj.v31i1.30621","volume":"31","author":"KMN Sabah","year":"2016","unstructured":"Sabah KMN, Chowdhury AW, Islam MS, et al. Cyanotic complex congenital heart disease presenting with brain abscess at the age of 19: a case report and review of literature. Bangladesh Heart J. 2016;31(1):41\u20135.","journal-title":"Bangladesh Heart J"},{"key":"4451_CR2","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.wneu.2017.07.144","volume":"107","author":"S Udayakumaran","year":"2017","unstructured":"Udayakumaran S, Onyia CU, Kumar RK. Forgotten? Not Yet. Cardiogenic brain abscess in children: a case series-based review. World Neurosurg. 2017;107:124\u20139. https:\/\/doi.org\/10.1016\/j.wneu.2017.07.144.","journal-title":"World Neurosurg."},{"issue":"8","key":"4451_CR3","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1111\/j.1651-2227.2010.01780.x","volume":"99","author":"Y Shachor-Meyouhas","year":"2010","unstructured":"Shachor-Meyouhas Y, Bar-Joseph G, Guilburd J, Lorber A, Hadash A, Kassis I. Brain abscess in children\u2013epidemiology, predisposing factors and management in the modern medicine era. Acta Paediatr. 2010;99(8):1163\u20137.","journal-title":"Acta Paediatr"},{"key":"4451_CR4","doi-asserted-by":"publisher","unstructured":"Reith W. The Brain. Diagnostic and interventional radiology. 2016:55\u2013268. https:\/\/doi.org\/10.1007\/978-3-662-44037-7_9","DOI":"10.1007\/978-3-662-44037-7_9"},{"key":"4451_CR5","doi-asserted-by":"crossref","unstructured":"Miranda HA, Leones SMC, Elzain MA, Moscote-Salazar LR. Brain abscess: current management. J Neurosci Rural Pract. 2013;4(S01):S67-S81.","DOI":"10.4103\/0976-3147.116472"},{"issue":"6","key":"4451_CR6","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1136\/heartjnl-2012-301685","volume":"101","author":"E Oechslin","year":"2015","unstructured":"Oechslin E. Management of adults with cyanotic congenital heart disease. Heart. 2015;101(6):485\u201394.","journal-title":"Heart"},{"issue":"4","key":"4451_CR7","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0733-8651(18)30147-4","volume":"11","author":"JK Perloff","year":"1993","unstructured":"Perloff JK. Systemic complications of cyanosis in adults with congenital heart disease. Hematologic derangements, renal function, and urate metabolism. Cardiol Clin. 1993;11(4):689\u201399.","journal-title":"Cardiol Clin"},{"issue":"2","key":"4451_CR8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.jacc.2006.03.040","volume":"48","author":"CS Broberg","year":"2006","unstructured":"Broberg CS, Bax BE, Okonko DO, et al. Blood viscosity and its relationship to iron deficiency, symptoms, and exercise capacity in adults with cyanotic congenital heart disease. J Am Coll Cardiol. 2006;48(2):356\u201365.","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04451-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04451-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04451-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T01:38:17Z","timestamp":1711589897000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04451-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4451"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04451-0","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]},"assertion":[{"value":"1 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient's legal guardian and patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors have declared no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"183"}}