{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:14:18Z","timestamp":1740147258129,"version":"3.37.3"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Diabetes insipidus is a syndrome characterized by polyuria, which is almost always associated with polydipsia. The most frequent cause is central diabetes insipidus, which is the result of an inadequate secretion of the antidiuretic hormone, and diagnosis involves differentiating it from other causes of polyuria and polydipsia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Here, we present a clinical case of a previously healthy 13-year-old Nepali boy, who, in December 2022, was found to have intense polydipsia accompanied by polyuria. He had bilateral lower limb weakness at the time of presentation. Biochemical evaluation demonstrated raised serum sodium (181\u00a0mEq\/L), serum creatinine (78\u00a0\u03bcmol\/L), and serum uric acid (560\u00a0\u03bcmol\/L) with suppressed serum potassium (2.7\u00a0mEq\/L), which was the major concern to the clinicians. Further laboratory workup revealed an increased serum osmolarity (393.6\u00a0mOsm\/kg) with reduced urine osmolarity (222.7\u00a0mOsm\/kg). On contrast magnetic resonance imaging of the brain, a thick-walled third ventricular cyst with bilateral foramen obstruction, thin membrane-like structure at top of aqueduct of Sylvius with gross obstructive hydrocephalus (inactive), and compressed and thinned pituitary gland with no bright spot was observed. The laboratory findings, radiological findings, and case presentation provided the provisional diagnosis of diabetes insipidus due to hydrocephalus and third ventricular cyst.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Central diabetes insipidus due to hydrocephalus, though rare, can have serious complications including the predilection to develop a deficit of other pituitary hormones. Thus, even if hydrocephalus is dormant with normal intracranial pressure, it must be addressed during investigations of central diabetes insipidus.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04467-6","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T01:02:27Z","timestamp":1711846947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antidiuretic hormone deficiency secondary to inactive hydrocephalus: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Anuradha","family":"Kadel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikita","family":"Kharal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srijana","family":"Sapkota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Pokhrel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aseem","family":"Bhattarai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithileshwer","family":"Raut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju Kumar","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eans Tara","family":"Tuladhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-7969","authenticated-orcid":false,"given":"Apeksha","family":"Niraula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"issue":"Suppl. 1","key":"4467_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000067844","volume":"59","author":"M Maghnie","year":"2003","unstructured":"Maghnie M. Diabetes insipidus. Horm Res Paediatr. 2003;59(Suppl. 1):42\u201354.","journal-title":"Horm Res Paediatr"},{"key":"4467_CR2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/B978-0-12-803247-3.00008-8","volume-title":"Textbook of nephro-endocrinology","author":"ML Moritz","year":"2018","unstructured":"Moritz ML, Ayus JC. Diabetes insipidus and syndrome of inappropriate antidiuretic hormone. In: Singh AK, Williams GH, editors. Textbook of nephro-endocrinology. Amsterdam: Elsevier; 2018. p. 133\u2013611."},{"issue":"6","key":"4467_CR3","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1001\/archpedi.1986.02140200061028","volume":"140","author":"NG Greger","year":"1986","unstructured":"Greger NG, Kirkland RT, Clayton GW, Kirkland JL. Central diabetes insipidus: 22 years\u2019 experience. 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This report does not contradict in any aspect the Helinski Declaration of 1975, as revised in 2000.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors disclose no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"133"}}