{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:40:58Z","timestamp":1787020858345,"version":"build-2736575974"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Castleman\u2019s disease is a rare lymphoproliferative disorder that is often misdiagnosed because of its untypical clinical or imaging features except for a painless mass. Besides, it is also difficult to cure Castleman\u2019s disease due to its unclear pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present a Castleman\u2019s disease case with diagnostic significance regarding a 54-year-old Chinese male who has a painless mass in his left parotid gland for 18\u00a0months with a 30-years history of autoimmune disease psoriasis. Computed tomography scan showed a high-density nodule with clear boundaries in the left parotid and multiple enlarged lymph nodes in the left submandibular and neck region. General checkup, the extremely elevated serum interleukin-6 and lymph node biopsy in the left submandibular region gave us an initial suspicion of Castleman\u2019s disease. Then the patient underwent a left superficial parotidectomy. Based on histopathologic analysis, we made a certain diagnosis of Castleman\u2019s disease and gave corresponding treatments. In 18\u00a0months of follow-up, the patient showed no evidence of recurrence, with the level of serum interleukin-6 decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinicians should be aware of the possibility of Castleman\u2019s disease when faced with masses or enlarged lymph nodes in the parotid gland to avoid misdiagnosis, especially in patients with autoimmune diseases and elevated serum interleukin-6.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-024-04468-5","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T20:02:14Z","timestamp":1712088134000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unicentric Castleman\u2019s disease in the parotid gland associated with psoriasis: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"issue":"3","key":"4468_CR1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/00000658-195803000-00018","volume":"147","author":"K Inada","year":"1958","unstructured":"Inada K, Hamazaki M. Localized mediastinal lymph-node hyperplasia resembling thymoma; a case report. Ann Surg. 1958;147(3):409\u201313. https:\/\/doi.org\/10.1097\/00000658-195803000-00018.","journal-title":"Ann Surg"},{"issue":"20","key":"4468_CR2","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1182\/blood-2018-07-862334","volume":"132","author":"F van Rhee","year":"2018","unstructured":"van Rhee F, Voorhees P, Dispenzieri A, Fossa A, Srkalovic G, Ide M, et al. International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease. Blood. 2018;132(20):2115\u201324. https:\/\/doi.org\/10.1182\/blood-2018-07-862334.","journal-title":"Blood"},{"issue":"7","key":"4468_CR3","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1007\/s00432-020-03494-2","volume":"147","author":"DP Sun","year":"2021","unstructured":"Sun DP, Chen WM, Wang L, Wang Z, Liang JH, Zhu HY, et al. Clinical characteristics and immunological abnormalities of Castleman disease complicated with autoimmune diseases. J Cancer Res Clin Oncol. 2021;147(7):2107\u201315. https:\/\/doi.org\/10.1007\/s00432-020-03494-2.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"4468_CR4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.5603\/ARM.2018.0008","volume":"86","author":"S Mitsos","year":"2018","unstructured":"Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N. The role of surgical resection in Unicentric Castleman\u2019s disease: a systematic review. Adv Respir Med. 2018;86(1):36\u201343. https:\/\/doi.org\/10.5603\/ARM.2018.0008.","journal-title":"Adv Respir Med"},{"issue":"4","key":"4468_CR5","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1097\/SLA.0b013e318249dcdc","volume":"255","author":"N Talat","year":"2012","unstructured":"Talat N, Belgaumkar AP, Schulte KM. Surgery in Castleman\u2019s disease: a systematic review of 404 published cases. Ann Surg. 2012;255(4):677\u201384. https:\/\/doi.org\/10.1097\/SLA.0b013e318249dcdc.","journal-title":"Ann Surg"},{"issue":"4","key":"4468_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0305-7372(95)90034-9","volume":"21","author":"MJ McCarty","year":"1995","unstructured":"McCarty MJ, Vukelja SJ, Banks PM, Weiss RB. Angiofollicular lymph node hyperplasia (Castleman\u2019s disease). Cancer Treat Rev. 1995;21(4):291\u2013310. https:\/\/doi.org\/10.1016\/0305-7372(95)90034-9.","journal-title":"Cancer Treat Rev"},{"issue":"3","key":"4468_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.30476\/DENTJODS.2020.85683.1144","volume":"22","author":"N Kardouni Khoozestani","year":"2021","unstructured":"Kardouni Khoozestani N, Niknami M, Ghanbarzadeh K, Ranji P. Castleman\u2019s disease intra parotid, a case report and literature review. J Dent (Shiraz). 2021;22(3):219\u201324. https:\/\/doi.org\/10.30476\/DENTJODS.2020.85683.1144.","journal-title":"J Dent (Shiraz)"},{"issue":"16","key":"4468_CR8","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1182\/blood.2019000931","volume":"135","author":"A Dispenzieri","year":"2020","unstructured":"Dispenzieri A, Fajgenbaum DC. Overview of Castleman disease. Blood. 2020;135(16):1353\u201364. https:\/\/doi.org\/10.1182\/blood.2019000931.","journal-title":"Blood"},{"key":"4468_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac481","author":"A Gonz\u00e1lez Garc\u00eda","year":"2022","unstructured":"Gonz\u00e1lez Garc\u00eda A, Fern\u00e1ndez-Mart\u00edn J, Robles Marhuenda \u00c1. Idiopathic multicentric Castleman disease and associated autoimmune and autoinflammatory conditions: practical guidance for diagnosis. Rheumatology (Oxford). 2022. https:\/\/doi.org\/10.1093\/rheumatology\/keac481.","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"4468_CR10","first-page":"277","volume":"55","author":"MA Mohagheghi","year":"2017","unstructured":"Mohagheghi MA, Omranipur R, Ensani F, Ghannadan A, Shahriaran S, Samiee F, et al. A case of advanced unicentric retroperitoneal Castleman\u2019s disease, associated with psoriasis. Acta Med Iran. 2017;55(4):277\u20139.","journal-title":"Acta Med Iran"},{"issue":"5","key":"4468_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2015.02.648","volume":"72","author":"AV Sears","year":"2015","unstructured":"Sears AV, Laftah Z, Al-Shakarchi I, Salisbury JR, Marcus R, Creamer D. Diagnosis of Castleman disease in a patient treated with prolonged anti-TNF biologic therapy for psoriasis and psoriatic arthritis. J Am Acad Dermatol. 2015;72(5):1. https:\/\/doi.org\/10.1016\/j.jaad.2015.02.648.","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"4468_CR12","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1182\/blood-2004-12-4602","volume":"106","author":"N Nishimoto","year":"2005","unstructured":"Nishimoto N, Kanakura Y, Aozasa K, Johkoh T, Nakamura M, Nakano S, et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood. 2005;106(8):2627\u201332. https:\/\/doi.org\/10.1182\/blood-2004-12-4602.","journal-title":"Blood"},{"issue":"23","key":"4468_CR13","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1200\/JCO.2009.27.2377","volume":"28","author":"F van Rhee","year":"2010","unstructured":"van Rhee F, Fayad L, Voorhees P, Furman R, Lonial S, Borghaei H, et al. Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman\u2019s disease. J Clin Oncol. 2010;28(23):3701\u20138. https:\/\/doi.org\/10.1200\/JCO.2009.27.2377.","journal-title":"J Clin Oncol"},{"key":"4468_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2019.08.002","volume":"43","author":"KA Lyapichev","year":"2019","unstructured":"Lyapichev KA, Sukswai N, Strati P, Iyer SP, Medeiros LJ, Miranda RN. Unicentric Castleman disease, hyaline vascular variant, stromal rich, with increased plasma cells and a high level of serum IL-6: raising the diagnostic and therapeutic issues. Ann Diagn Pathol. 2019;43: 151398. https:\/\/doi.org\/10.1016\/j.anndiagpath.2019.08.002.","journal-title":"Ann Diagn Pathol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04468-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04468-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04468-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T20:02:23Z","timestamp":1712088143000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04468-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4468"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04468-5","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"assertion":[{"value":"3 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval is not needed by the local Ethics Committee for case reports.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"140"}}