{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:04:37Z","timestamp":1760061877870},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Primary brain rhabdomyosarcoma is a rare primary brain malignancy with few case reports. The vast majority of cases of primary brain rhabdomyosarcoma occur in pediatric patients, and immunohistochemistry can distinguish it from embryonal subtypes; however, few cases of primary brain rhabdomyosarcoma in adults have been reported in the literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report the case of a 26-year-old White male patient who was found to have primary brain alveolar rhabdomyosarcoma after developing headaches for several months. A brain MRI revealed a mixed cystic and solid tumor along the vermis of the cerebellum. The patient underwent a gross total surgical resection, which confirmed the diagnosis of alveolar rhabdomyosarcoma. Further staging workup for another primary focus or disseminated disease yielded negative results, confirming the diagnosis of primary alveolar rhabdomyosarcoma of the brain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The standard of care for managing this rare type of brain tumor involves surgery with adjuvant chemoradiotherapy. Further studies should be conducted for a better diagnostic and therapeutic understanding.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04471-w","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T01:01:46Z","timestamp":1711155706000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary alveolar rhabdomyosarcoma of the brain: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Layal","family":"Al Mahmasani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"Najjar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roula","family":"Hourany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer","family":"Tabbarah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sinno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Chamseddine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reine","family":"Abou Zeidane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghid","family":"Amhaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem I.","family":"Assi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"4471_CR1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s12253-008-9012-5","volume":"14","author":"D Morgenstern","year":"2008","unstructured":"Morgenstern D, Rees H, Sebire N, Shipley J, Anderson J. Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature. Pathol Oncol Res. 2008;14:233\u20138.","journal-title":"Pathol Oncol Res"},{"issue":"2","key":"4471_CR2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/BF02571302","volume":"5","author":"EJ Dropcho","year":"1987","unstructured":"Dropcho EJ, Allen JC. Primary intracranial rhabdomyosarcoma: case report and review of the literature. J Neurooncol. 1987;5(2):139\u201350.","journal-title":"J Neurooncol"},{"issue":"12","key":"4471_CR3","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1007\/s00381-003-0839-5","volume":"19","author":"M Al-Gahtany","year":"2003","unstructured":"Al-Gahtany M, Shroff M, Bouffet E, Dirks P, Drake J, Humphreys R, et al. Primary central nervous system sarcomas in children: clinical, radiological, and pathological features. Childs Nerv Syst. 2003;19(12):808\u201317.","journal-title":"Childs Nerv Syst"},{"issue":"5","key":"4471_CR4","doi-asserted-by":"publisher","first-page":"762","DOI":"10.5858\/2000-124-0762-PMRIAC","volume":"124","author":"F Xu","year":"2000","unstructured":"Xu F, De Las Casas LE, Dobbs LJ Jr. Primary meningeal rhabdomyosarcoma in a child with hypomelanosis of Ito. Arch Pathol Lab Med. 2000;124(5):762\u20135.","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"4471_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11060-013-1204-5","volume":"115","author":"MR Khalatbari","year":"2013","unstructured":"Khalatbari MR, Hamidi M, Moharamzad Y. Primary alveolar rhabdomyosarcoma of the brain with long-term survival. J Neurooncol. 2013;115(1):131\u20133.","journal-title":"J Neurooncol"},{"issue":"5","key":"4471_CR6","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1200\/JCO.1997.15.5.1831","volume":"15","author":"KM Kelly","year":"1997","unstructured":"Kelly KM, Womer RB, Sorensen PH, Xiong QB, Barr FG. Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma. J Clin Oncol. 1997;15(5):1831\u20136.","journal-title":"J Clin Oncol"},{"key":"4471_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/312802","volume":"2011","author":"M Palta","year":"2011","unstructured":"Palta M, Riedel RF, Vredenburgh JJ, Cummings TJ, Green S, Chang Z, et al. Primary meningeal rhabdomyosarcoma. Sarcoma. 2011;2011: 312802.","journal-title":"Sarcoma"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04471-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04471-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04471-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T01:01:57Z","timestamp":1711155717000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04471-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,23]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4471"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04471-w","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2024,3,23]]},"assertion":[{"value":"1 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors complied with the ethical requirements of their institution.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"178"}}