{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:26:10Z","timestamp":1714004770896},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Sex cord-stromal tumors with annular tubules are a rare tumor accounting for less than 1% of all ovarian malignancies. However, they are characterized by very late recurrence, which can be as late as 30 years after diagnosis and treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 16-year-old female Caucasian patient was treated in our department for a  stage IA ovarian sex cord-stromal tumors with annular tubules. She underwent a left salpingo-oophorectomy and ipsilateral pelvic node biopsy with no adjuvant treatment. She was seen for amenorrhea after being lost to follow up for 16\u00a0years. The diagnosis of recurrence was made by radiology and the elevation of serum inhibin B level. The patient underwent resection of the tumor, left segmental colectomy, and paraaortic lymphadenectomy because the mass was massively adherent to the left mesocolon. Histology confirmed the diagnosis with no metastatic lymph nodes. No adjuvant therapy was indicated. The patient was lost to follow-up again for 4\u00a0years and re-presented for amenorrhea. Serum inhibin B level was high. A second recurrence was suggested, and the patient underwent a laparoscopic surgery. We performed left pelvic and paraaortic lymphadenectomy, and 3\u00a0months after surgery the patient was pregnant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Sex cord-stromal tumors with annular tubules is a slow-growing ovarian tumor with a high potential for recurrence and metastasis. Surgery is the mainstay of treatment. Due to the rarity of these tumors, they are often unsuspected and thus incompletely staged before primary surgery; the diagnosis is made by histological examination. The prognosis of these patients is unknown, and they require long-term follow-up.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04476-5","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:01:28Z","timestamp":1713916888000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exceptional lymph node recurrence of an unusual ovarian tumor 16 years later: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Saida","family":"Sakhri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maher","family":"Slimane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanen","family":"Bouaziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayssem","family":"Khessairi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Boujelbene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Ben Dhiab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"issue":"1","key":"4476_CR1","first-page":"61","volume":"10","author":"N Kulkarni","year":"2015","unstructured":"Kulkarni N. Recurrence of non-syndromic sex cord stromal tumor with annular tubules of ovary: case report. Iran J Pathol. 2015;10(1):61\u20134.","journal-title":"Iran J Pathol"},{"issue":"3","key":"4476_CR2","doi-asserted-by":"publisher","first-page":"030006052199656","DOI":"10.1177\/0300060521996563","volume":"49","author":"C Li","year":"2021","unstructured":"Li C, Aishajiang R, Teng Y, Xu T, Ding L, Dong L. Non-Peutz\u2013Jeghers syndrome-associated ovarian sex cord tumor with annular tubules treated by radiotherapy: a case report and literature review. J Int Med Res. 2021;49(3):0300060521996563.","journal-title":"J Int Med Res"},{"issue":"45","key":"4476_CR3","doi-asserted-by":"publisher","first-page":"omaa024","DOI":"10.1093\/omcr\/omaa024","volume":"2020","author":"JJ Yahaya","year":"2020","unstructured":"Yahaya JJ, Mshana D, Mremi A. Ovarian sex cord tumour with annular tubules in a 13-year-old female: a case report. Oxf Med Case Rep. 2020;2020(45):omaa024.","journal-title":"Oxf Med Case Rep."},{"key":"4476_CR4","doi-asserted-by":"crossref","unstructured":"Harbi RA, McNeish IA, El-Bahrawy M. Ovarian sex cord-stromal tumors: an update on clinical features, molecular changes, and management. Int J Gynecol Cancer. 2021\u00a0;31(2). Disponible sur: https:\/\/ijgc.bmj.com\/content\/31\/2\/161. Accessed 26 Mar 2023.","DOI":"10.1136\/ijgc-2020-002018"},{"key":"4476_CR5","unstructured":"IJCMCR-CR-ID-00421\u2014International Journal of Clinical Studies & Medical Case Reports. Disponible sur: https:\/\/ijclinmedcasereports.com\/ijcmcr-cr-id-00421\/. Accessed 13 May 2023."},{"issue":"2","key":"4476_CR6","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ygyno.2011.03.020","volume":"122","author":"MM Thrall","year":"2011","unstructured":"Thrall MM, Paley P, Pizer E, Garcia R, Goff BA. Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. 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Transl Cancer Res mars. 2020;9(3):2089\u201394.","journal-title":"Transl Cancer Res mars"},{"issue":"2","key":"4476_CR9","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1006\/gyno.1993.1030","volume":"48","author":"K Shen","year":"1993","unstructured":"Shen K, Wu PC, Lang JH, Huang RL, Tang MT, Lian LJ. Ovarian sex cord tumor with annular tubules: a report of six cases. Gynecol Oncol. 1993;48(2):180\u20134.","journal-title":"Gynecol Oncol"},{"issue":"2","key":"4476_CR10","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.fertnstert.2006.11.128","volume":"88","author":"Y Yinon","year":"2007","unstructured":"Yinon Y, Beiner ME, Gotlieb WH, Korach Y, Perri T, Ben-Baruch G. Clinical outcome of cystectomy compared with unilateral salpingo-oophorectomy as fertility-sparing treatment of borderline ovarian tumors. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"217"}}