{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:43:50Z","timestamp":1789400630569,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Plasmapheresis represent an alternative therapeutic option for hyperthyroidism with thyroid storm or refractory cases. It provides a rapid decrease in plasma thyroid hormones and anti-thyroid antibodies. The aim of this paper was to report our single center\u2019s experience in managing particular situations of hyperthyroidism using apheresis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Cases presentation<\/jats:title>\n                <jats:p>The following case series describes three young African patients (two females, one male) aged 29, 37, and 25\u00a0years old, respectively, with Graves\u2019 disease who presented with drug ineffectiveness, drug-induced agranulocytosis, and thyroid storm with multi-organ failure. The three patients underwent plasmapheresis sessions leading to effective decline of thyroid hormone levels and offering a window for processing total thyroidectomy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion\/conclusion<\/jats:title>\n                <jats:p>The standard management of thyrotoxicosis and thyroid storm was usually codified by the concomitant use of antithyroid medication, iodine, beta-blockers, and corticosteroids. This medical preparation can be effective in most cases. However, drug toxicity or ineffectiveness can limit the use of such therapeutics. Our paper supports the efficiency and safety of therapeutic plasma exchange in the preoperative management of thyrotoxicosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04480-9","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T01:15:45Z","timestamp":1711761345000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasmapheresis in thyrotoxicosis: a single-center case series"],"prefix":"10.1186","volume":"18","author":[{"given":"I.","family":"Rami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zerrouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Assarrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Latrech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"issue":"26","key":"4480_CR1","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/thy.2016.0229","volume":"2016","author":"DS Ross","year":"2016","unstructured":"Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL. American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016;2016(26):1343\u2013421.","journal-title":"Thyroid"},{"issue":"10047","key":"4480_CR2","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S0140-6736(16)00278-6","volume":"88","author":"S De Leo","year":"2016","unstructured":"De Leo S, Lee SYBL. Hyperthyroidism. Lancet. 2016;88(10047):906\u201318.","journal-title":"Lancet"},{"key":"4480_CR3","doi-asserted-by":"crossref","unstructured":"Miller A SK. Thyroid storm with multiorgan failure treated with plasmapheresis. Case Rep Endocrinol. 2019;1\u20135.","DOI":"10.1155\/2019\/2475843"},{"issue":"7","key":"4480_CR4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1159\/000490384","volume":"2018","author":"GJ Kahaly","year":"2018","unstructured":"Kahaly GJ, Bartalena L, Heged\u00fcs L, Leenhardt L, Poppe KPS. European Thyroid Association guideline for the management of Graves\u2019 hyperthyroidism. Eur Thyroid J. 2018;2018(7):167\u201386.","journal-title":"Eur Thyroid J"},{"issue":"3","key":"4480_CR5","first-page":"149","volume":"31","author":"J Schwartz","year":"2016","unstructured":"Schwartz J, Padmanabhan A, Aqui N, et\u00a0al. Guidelines on the use of therapeutic apheresis in clinical practice\u2014evidence-based approach from the writing Committee of the American Society for Apheresis: the seventh special issue. J Clin Apher. 2016;31(3):149\u201362.","journal-title":"J Clin Apher."},{"key":"4480_CR6","unstructured":"L W. Thyrotoxic storm. In: Braverman LE, Utiger RD, editors. Werner\u2019s and Ingbar\u2019s the thyroid: a fundamental and clinical text. Lippincott Williams & Wilkins. 2000;679\u201384."},{"key":"4480_CR7","doi-asserted-by":"crossref","unstructured":"Carhill A, Gutierrez A, Lakhia R, Nalini R. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The Authors declare that there is no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"193"}}