{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T05:14:46Z","timestamp":1755839686911,"version":"3.37.3"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Herbal products and traditional remedies are commonly used by individuals worldwide for the management of common ailments, even though most are not without risks. <jats:italic>Acalypha indica<\/jats:italic> is a popular medicinal plant consumed in some Asian countries.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>This case report presents a 40-year-old previously unevaluated Sri Lankan female and her 8-year-old son who presented with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency related acute intravascular oxidative haemolysis and methaemoglobinaemia precipitated by <jats:italic>Acalypha indica<\/jats:italic> consumption, successfully managed with supportive care and blood transfusion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case highlights the potential hemolytic and methaemoglobinaemic effects of ingesting oxidant herbal products and the importance of considering such exposures in patients presenting with hemolysis and multiorgan involvement, particularly in communities where herbal product intake is popular. Healthcare providers should be aware of the risks associated with traditional remedies and maintain a high index of suspicion to ensure prompt recognition and appropriate management.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04481-8","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T01:02:20Z","timestamp":1710810140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acalypha indica induced acute oxidative haemolysis and methaemoglobinaemia: two case reports"],"prefix":"10.1186","volume":"18","author":[{"given":"Kusala","family":"Maddumabandara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-8962","authenticated-orcid":false,"given":"Arun","family":"Rajaratnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ishfak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimali","family":"Samarakoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kithmini","family":"Ellepola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Bowattage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"4481_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jep.2017.06.019","volume":"207","author":"NS Zahidin","year":"2017","unstructured":"Zahidin NS, Saidin S, Zulkifli RM, Muhamad II, Yaakob H, Nur H. A review of Acalypha indica L. (Euphorbiaceae) as traditional medicinal plant and its therapeutic potential. J Ethnopharmacol. 2017;207:146\u201373. https:\/\/doi.org\/10.1016\/j.jep.2017.06.019.","journal-title":"J Ethnopharmacol"},{"key":"4481_CR2","doi-asserted-by":"publisher","first-page":"539","DOI":"10.2147\/IJGM.S263199","volume":"13","author":"A Pradoo","year":"2020","unstructured":"Pradoo A, Sriapha C, Trakulsrichai S, Tongpoo A, Kheiawsawang M, Wananukul W. Clinical characteristics of Acalypha indica poisoning. Int J Gen Med. 2020;13:539\u201345. https:\/\/doi.org\/10.2147\/IJGM.S263199.","journal-title":"Int J Gen Med"},{"key":"4481_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2325-9841.1000116","volume":"3","author":"D Narasimhan","year":"2014","unstructured":"Narasimhan D, Sujith SK, Murali A, Satish M, Mambatta AK. Acute intravascular hemolysis triggered by herbal remedy. J Forensic Toxicol Pharmacol. 2014;3:1. https:\/\/doi.org\/10.4172\/2325-9841.1000116.","journal-title":"J Forensic Toxicol Pharmacol"},{"key":"4481_CR4","doi-asserted-by":"crossref","unstructured":"Gunawardena S, Kapilananda GM, Samarakoon D, Maddevithana S, Wijesundera S, Goonaratne LV, Karunaweera ND. Prevalence of G6PD deficiency in selected populations from two previously high malaria endemic areas of Sri Lanka. PLoS ONE. 2017;12(2).","DOI":"10.1371\/journal.pone.0171208"},{"issue":"1","key":"4481_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/inthealth\/ihy060","volume":"11","author":"GJ Domingo","year":"2019","unstructured":"Domingo GJ, Advani N, Satyagraha AW, Sibley CH, Rowley E, Kalnoky M, Cohen J, Parker M, Kelley M. Addressing the gender-knowledge gap in glucose-6-phosphate dehydrogenase deficiency: challenges and opportunities. 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Trop Doct. 1996;26(1):32. https:\/\/doi.org\/10.1177\/004947559602600113.","journal-title":"Trop Doct"},{"issue":"1","key":"4481_CR8","first-page":"46","volume":"39","author":"SP Lamabadusuriya","year":"1994","unstructured":"Lamabadusuriya SP, Jayantha UK. Acalypha indica induced haemolysis in G6PD deficiency. Ceylon Med J. 1994;39(1):46\u20137.","journal-title":"Ceylon Med J"},{"key":"4481_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s13104-018-3286-9","volume":"11","author":"NDB Ehelepola","year":"2018","unstructured":"Ehelepola NDB, Abayagunawardana AN, Sudusinghe TN. A vegetable-induced hemolytic crisis in a G6PD deficient person: a case report. BMC Res Notes. 2018;11:179. https:\/\/doi.org\/10.1186\/s13104-018-3286-9.","journal-title":"BMC Res Notes"},{"issue":"1","key":"4481_CR10","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s13312-021-2113-x","volume":"58","author":"B Pallapothu","year":"2021","unstructured":"Pallapothu B, Sankar J. 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Copies of the written consent are available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors do not have any competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"163"}}