{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:13:17Z","timestamp":1788909197497,"version":"build-2803163510"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Red Ear Syndrome is a burning sensation and erythema of the ear, associated with a various number of disorders including migraine, trigeminal neuralgia, autoimmune disorders etc. Theories for RES pathophysiology have developed from current understandings of comorbid conditions. Characterizing the underlying mechanism of RES is crucial for defining effective treatments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Three caucasian patients, ages 15, 47, and 67\u00a0years, with migraine, one with erythromelalgia are reported in this manuscript. RES pathophysiology is not fully understood due to its variable clinical presentation and numerous comorbid conditions, making it difficult to identify effective treatments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>RES seems to be largely treatment-resistant, and most options involve treating the associated disorders and minimizing pain. Further investigation of future cases should lead to a more comprehensive understanding of the fundamental cause of RES and, hopefully, successful treatments.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04485-4","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:01:54Z","timestamp":1720483314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Red ear syndrome: a\u00a0case series\u00a0and review of the literature"],"prefix":"10.1186","volume":"18","author":[{"given":"Grace M.","family":"Callan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Freitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-880X","authenticated-orcid":false,"given":"Amir Soheil","family":"Tolebeyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"issue":"3","key":"4485_CR1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1212\/wnl.47.3.617","volume":"47","author":"JW Lance","year":"1996","unstructured":"Lance JW. The red ear syndrome. Neurology. 1996;47(3):617\u201320. https:\/\/doi.org\/10.1212\/wnl.47.3.617.","journal-title":"Neurology"},{"issue":"1","key":"4485_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/1129-2377-14-83","volume":"14","author":"G Lambru","year":"2013","unstructured":"Lambru G, Miller S, Matharu MS. The red ear syndrome. J Headache Pain. 2013;14(1):83. https:\/\/doi.org\/10.1186\/1129-2377-14-83.","journal-title":"J Headache Pain"},{"key":"4485_CR3","doi-asserted-by":"publisher","first-page":"110615","DOI":"10.1016\/j.ijporl.2021.110615","volume":"142","author":"A D'Amico","year":"2021","unstructured":"D\u2019Amico A, Galati C, Manzo M, et al. Red ear syndrome in children: review of literature and report of three cases. 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The patents\u2019 consent forms are attached.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patients for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"327"}}